Publication Type |
Journal Article |
School or College |
College of Engineering |
Department |
Bioengineering |
Creator |
Christensen, Douglas A.; Herron, James N. |
Other Author |
Wang, Hsu-Kun; Terry, Alan H.; Durtschi, Jacob D.; Tan, Lyndon; Astill, Mark E.; Smith, Richard S. |
Title |
Rapid clinical diagnostics assays using injection-molded planar waveguides |
Date |
1998 |
Description |
The goal of our research program is to develop an evanescent wave immunoassay system that can be used in point-of-care and critical care settings. Several key attributes are required to accomplish this goal: (i) the assay system should be at least as sensitive as present day immunoassays; (ii) assay time should be 5 minutes or less; (iii) the assay protocol should be relatively simple; (iv) the sensor should be capable of performing more than one assay on a single specimen; (v) the assay system should be able to accommodate specimens such as serum, plasma and whole blood; and (vi) the sensor should be an inexpensive, disposable cartridge. Our laboratory has developed an injection-molded planar waveguide sensor that meets most, if not alt, of these attributes. This sensor has been evaluated in a number of different immunoassays for analytes such as bovine serum albumin, human chorionic gonadotrophin, creatine phosphokinase MB and cardiac troponin I. |
Type |
Text |
Publisher |
International Society for Optical Engineering (SPIE) |
Volume |
3259 |
First Page |
54 |
Last Page |
64 |
DOI |
10.1117/12.307322 |
Subject |
Planar waveguides; Creatine phosphokinase MB (CK-MB); Cardiac troponin I (cTnl); Diagnostics; Evanescence; Fluorescence; Human chorionic gonadotropin (hCG) |
Subject LCSH |
Immunoassay; Wave guides; Biosensors; Immunodiagnosis; Chorionic gonadotropins |
Language |
eng |
Bibliographic Citation |
Herron, J. N., Wang, H.-K., Terry, A. H., Durtschi, J. D., Tan, L., Astill, M. E., Smith, R. S., & Christensen, D. A. (1998). Rapid clinical diagnostics assays using injection-molded planar waveguides. Proceedings of SPIE - The International Society for Optical Engineering, 3259, 54-64. |
Rights Management |
©Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.307322 |
Format Medium |
application/pdf |
Format Extent |
1,162,837 bytes |
Identifier |
ir-main,11667 |
ARK |
ark:/87278/s6jt07n5 |
Setname |
ir_uspace |
ID |
703592 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6jt07n5 |