Attack of the Clones

Update Item Information
Identifier walsh_2004_s1_c2
Title Attack of the Clones
Creator M. Tariq Bhatti, MD; Donna Hill, MD; Michael S. Okun, MD
Affiliation Gainesville, Florida
Subject Waldenstrom Macroglobulinemia; Leukoencephalopathies; Diplopia
History A 61-year old female with a sudden onset of left-sided weakness and numbness.
Pathology Monoclonal population of lymphocytes infiltrating peri-vascular spaces.
Disease/Diagnosis Waldenstrom Macroglobulinemia (Bing-Neel Syndrome)
Clinical VA: 20/30 OD, 20/25 OS
Presenting Symptom Diplopia; Headache; Confusion; Hallucinations
Neuroimaging MRI; MRA
Treatment IV steroids
Date 2004
References 1. Dimopoulos MA, Galani E, Matsouka C. Waldenstrom's macroglobulinemia. Hematol Oncol Clin North Am 1999, 13: 1351-66. 2. Desikan KR, Dhodapkar MV, Barlogie B. Waldenstrom's macroglobulinemia. Curr Treat Options Oncol 2000;1:97-103. 3. Orellana J, Friedman AH. Ocular manifestations of multiple myeloma, Waldenstrom's macroglobulinemia and benign monoclonal gammopathy. Surv Ophthalmol 1981;26:157-69. 4. Rosenbaum JT, Becker MD. The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. Ocul Immunol Inflamm 2000;8:111-3. 5. Knox CM, Wong IG, Howes EL, Barkin A, Kearney J. Vitritis and Waldenstrom's macroglobulinemia. Am J Ophthalmol 1998;126:314-5. 6. Klapper SR, Jordan DR, Pelletier C, Brownstein S, Punja K. Ptosis in Waldenstrom's macroglobulinemia. Am J Ophthalmol 1998;126:315-7. 7. Little JM. Waldenstrom's macroglobulinemia in the lacrimal gland. Trans Am Acad Ophthalmol Otolaryngol 1967;71:875-9. 8. Terasaki H, Kikuchi S, Hoshi S. Ophthalmic tumor formation in Waldenstrom's macroglobulinemia. Jpn J Ophthalmol 1996;40:385-9. 9. Cordido M, Fernandez-Lago C, Fernandez-Vigo J, Lopez-Nieto C. Dry eye in Waldenstrom's macroglobulinemia. Improvement after systemic chemotherapy. Cornea 1995;14:210-1. 10. Giarelli L, Melato M, Falconieri G. Eye involvement in Waldenstrom's macroglobulinaemia. Ophthalmologica 1982;185:214-9. 11. Thomas EL, Olk RJ, Markman M, Braine H, Patz A. Irreversible visual loss in Waldenstrom's macroglobulinaemia. Br J Ophthalmol 1983;67:102-6. 12. Ho AC, Benson WE, Wong J. Unusual immunogammopathy maculopathy. Ophthalmology 2000;107:1099-103. 13. Delgado J, Canales MA, Garcia B, Alvarez-Ferreira J, Garcia-Grande A, Hernandez-Navarro F. Radiation therapy and combination of cladribine, cyclophosphamide, and prednisone as treatment of Bing-Neel syndrome: Case report and review of the literature. Am J Hematol 2002;69:127-31. 14. Scheithauer BW, Rubinstein LJ, Herman MM. Leukoencephalopathy in Waldenstrom's macroglobulinemia. Immunohistochemical and electron microscopic observations. J Neuropathol Exp Neurol 1984;43:408-25. 15. Waldenstrom J. Incipient myelomatosis or 'essential' hyperglobulinemia with fibrogenopenia: a new syndrome? Acta Med Scandinav 1944;117:216-247. 16. Bing J, Neel AV. Two cases of hyperglobulinaemia with affection of the central nervous system on a toxi-infectious basis. Acta Med Scandinav 1936;88:492-506. 17. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 8-2001. A 61-year-old man with transient quadriplegia and apnea. N Engl J Med 2001;344:832-9. 18. Welch D, Whetsell WO, Jr., Weil RJ. Pathologic quiz case. A man with long-standing monoclonal gammopathy and new onset of confusion. Central nervous system involvement by Waldenstrom macroglobulinemia-Bing-Neel syndrome. Arch Pathol Lab Med 2002;126:1243-4. 19. Aparicio A, Chamberlain MC. Neoplastic meningitis. Curr Neurol Neurosci Rep 2002;2:225-35.
Language eng
Format application/pdf
Type Text
Source 30th Annual North American Neuro-Ophthalmology Society Meeting, Frank B. Walsh Session CD-ROM
Relation is Part of NANOS Annual Meeting Frank B. Walsh Sessions; 2004
Collection Neuro-Ophthalmology Virtual Education Library: Walsh Session Annual Meeting Archives: https://novel.utah.edu/Walsh/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2008. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6zw1pmw
Setname ehsl_novel_fbw
ID 177579
Reference URL https://collections.lib.utah.edu/ark:/87278/s6zw1pmw