Permanent Transduction of Retinal Ganglion Cells by Injection of rAAV2-retro into the Superior Colliculus
| Identifier | 20240305_nanos_sciplatform3_05 |
| Title | Permanent Transduction of Retinal Ganglion Cells by Injection of rAAV2-retro into the Superior Colliculus |
| Creator | Jonathan Horton; Mikayla Dilbeck; John Economides; Yicen Zheng |
| Affiliation | (JH) University of California San Francisco; (MD) (JE) (YZ) UCSF |
| Subject | Genetic Disease; Optic Neuropathy; Retina |
| Description | Injection of rAAV2-retro into the superior colliculus offers a potential route for delivery of therapeutic genes to ganglion cells. This approach eliminates the barrier posed by the internal limiting membrane, a major problem following intravitreal virus injection. However, it is unknown for how long the gene product continues to be expressed by ganglion cells. |
| Date | 2024-03 |
| References | Tervo, D.G., Hwang, B.Y., Viswanathan, S., Gaj, T., Lavzin, M., et al,. A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons. Neuron 92, 372-382, 2016. Nanjappa, R., Dilbeck, M.D., Economides, J.R., Horton, J.C., Fundus imaging of retinal ganglion cells transduced by retrograde transport of rAAV2-retro. Exp Eye Res, 219:109084, 2022. Cushnie, A.K., El-Nahal, H.G., Bohlen, M.O., May, P.J., Basso, M.A., et al, Using rAAV2-retro in rhesus macaques: Promise and caveats for circuit manipulation. J. Neurosci. Methods 345, 108859, 2020. |
| Language | eng |
| Format | application/pdf |
| Format Creation | Microsoft PowerPoint |
| Type | Text |
| Source | 2024 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of | NANOS Annual Meeting 2024: Scientific Platform Session III |
| Collection | Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher | North American Neuro-Ophthalmology Society |
| Holding Institution | Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management | Copyright 2024. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK | ark:/87278/s6zc7ze0 |
| Setname | ehsl_novel_nam |
| ID | 2593100 |
| Reference URL | https://collections.lib.utah.edu/ark:/87278/s6zc7ze0 |