Ophthalmologic Complications in NF1 Patients Treated with MEK Inhibitors
| Identifier | 20240305_nanos_posters_476 |
| Title | Ophthalmologic Complications in NF1 Patients Treated with MEK Inhibitors |
| Creator | May Ameri; Lena Hummel; Shaikha AlQahtani; Zsila Sadighi; Nagham Al-Zubidi |
| Affiliation | (MA) University of Texas McGovern Medical School; (LH) University of Texas Medical Branch; (SA) (ZS) UT MD Anderson Cancer Center;(NA)University of Texas MD Anderson Cancer Center |
| Subject | Tumors; Pediatric Neuro-ophthalmology; Chemotherapy and Radiation Injury |
| Description | MEK inhibitors are novel, promising therapies for Neurofibromatosis type 1 (NF1) manifestations including optic gliomas. Due to known potential ophthalmic side effects, such as MEKi associated retinopathy (MEKAR), patients undergoing MEKi treatment receive routine ophthalmology evaluation. Our study scrutinizes the necessity of such routine screening in a largely pediatric population of NF1 patients on MEKi by examining the frequency of ocular adverse events (OAE). |
| Date | 2024-03 |
| References | ASCIERTO, P. A.; SCHADENDORF, D.; BERKING, C.; AGARWALA, S. S. et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol, 14, n. 3, p. 249-256, Mar 2013. FLAHERTY, K. T.; INFANTE, J. R.; DAUD, A.; GONZALEZ, R. et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med, 367, n. 18, p. 1694-1703, Nov 01 2012. MÉNDEZ-MARTÍNEZ, S.; CALVO, P.; RUIZ-MORENO, O.; PARDIÑAS BARÓN, N. et al. OCULAR ADVERSE EVENTS ASSOCIATED WITH MEK INHIBITORS. Retina, 39, n. 8, p. 1435-1450, Aug 2019. URNER-BLOCH, U.; URNER, M.; JABERG-BENTELE, N.; FRAUCHIGER, A. L. et al. MEK inhibitorassociated retinopathy (MEKAR) in metastatic melanoma: Long-term ophthalmic effects. Eur J Cancer, 65, p. 130-138, Sep 2016. WEBER, M. L.; LIANG, M. C.; FLAHERTY, K. T.; HEIER, J. S. Subretinal Fluid Associated With MEK Inhibitor Use in the Treatment of Systemic Cancer. JAMA Ophthalmol, 134, n. 8, p. 855-862, Aug 01 2016. |
| Language | eng |
| Format | application/pdf |
| Type | Text |
| Source | 2024 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of | NANOS Annual Meeting 2024: Poster Session: Analytical Studies: Pediatric Neuro-Ophthalmology |
| Collection | Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher | North American Neuro-Ophthalmology Society |
| Holding Institution | Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management | Copyright 2024. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK | ark:/87278/s6yzmpxg |
| Setname | ehsl_novel_nam |
| ID | 2594300 |
| Reference URL | https://collections.lib.utah.edu/ark:/87278/s6yzmpxg |