Identifier |
20180306_nanos_posters_233 |
Title |
Physiologic Dysfunction Precedes Retinal Ganglion Cell Loss in Mice with Neurofibromatosis and Optic Pathway Gliomas |
Creator |
Steven Stasheff, Francisco Nadal-Nicolas, Emmanuelle Jecrois, Wei Li, Miriam Bornhorst, Yuan Zhu |
Subject |
Genetic Disease, Neuro-ophth & systyemic disease ( eg. MS, MG, thyroid), Pediatric neuro-ophthalmology, Genetic Disease |
Description |
We report previously unrecognized developmental abnormalities of retinal ganglion cell (RGC) anatomy and physiology that may help explain a striking disparity in young children with neurofibromatosis type 1 (NF1) who develop optic pathway gliomas (OPGs): the degree of visual loss is inadequately predicted by tumor characteristics or treatment response. In an animal model, we find RGC loss in discrete sectors months after tumor formation, but also greatly disrupted physiology among surviving retinal ganglion cells (RGCs). |
Date |
2018-03 |
Language |
eng |
Format |
application/pdf |
Source |
2018 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2018: Poster Presentations |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2018. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6vx4gv3 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Contributor Primary |
Steven Stasheff |
Contributor Secondary |
Francisco Nadal-Nicolas, Emmanuelle Jecrois, Wei Li, Miriam Bornhorst, Yuan Zhu |
Setname |
ehsl_novel_nam |
ID |
1310568 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6vx4gv3 |