Identifier |
20180305_nanos_sciplatform1_04-1 |
Title |
Interocular Phase Delay Shifts Visual Cortical Dominance: a Potential New Therapeutic Approach for Amblyopia |
Creator |
Eric Gaier; Daniel Montgomery; Arnold Heynen; Mark Bear |
Affiliation |
(EG) Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; (DM) (AH) (MB) Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts |
Subject |
Pediatric Neuro-ophthalmology; Miscellaneous |
Description |
Amblyopia imparts a delay in visually evoked response (VEP) latency (~5 ms/2 Snellen lines) through the affected eye that neutralizes with successful treatment [1, 2]. The delay in signals reaching the visual cortex may actively preclude visual recovery of the affected eye since delay of synaptic activation tends to weaken visual cortical synapses [3]. Along this line, manipulation of interocular stimulus phase could strengthen the amblyopic eye. To this goal, we hypothesized that introduction of an interocular phase delay would induce plasticity in the visual cortex to shift ocular dominance. |
Date |
2018-04 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2018 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2018: Scientific Platform, Session I |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2018. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6vq7524 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1316063 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6vq7524 |