Inter-Eye Difference Threshold in Retinal Nerve Fiber Layer Thickness that Predicts an Optic Nerve Lesion

The optic nerve and anterior visual pathway are frequent sites for involvement in multiple sclerosis (MS). OCT can be used to detect thinning of the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL+IPL) in eyes of patients with MS or in the case of clinically- or radiologically-isolated syndromes. We sought to determine a threshold of inter-eye difference in RNFL thickness predictive of an optic nerve lesion.