Effect of Prostaglandin Analogs on Cerebrospinal Fluid Reabsorption Via Nasal Mucosa
Creator
Prem S. Subramanian, Michelle G. Pedler, J. Mark Petrash
Affiliation
(PSS) (MGP) (JMP) Sue Anschutz-Rodgers UCHealth Eye Center/University of Colorado School of Medicine, Aurora, CO
Subject
High Intracranial Pressure/Headache; Pseudotumor Cerebri
Description
Cerebrospinal fluid (CSF) outflow has been demonstrated along nasal lymphatics via olfactory nerve projections; flow may be increased by stimulating lymphatic contractility using agents such as noradrenaline and the thromboxane A2 analog U46619. Lymphatics elsewhere in the body show increased contractility upon exposure to the prostaglandin F2alpha analog isoprostane-8- epi-prostaglandin. We investigated the ability of ophthalmic prostaglandin F2alpha analogs to increase CSF outflow when applied to the nasal mucosa by inhalation.
Date
2021-02
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
2021 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of
NANOS Annual Meeting 2021: Journal Club: What You Need to Know Now!
