Epigenetic Reprogramming- A Novel Gene Therapy to Rejuvenate Injury-Induced Dysfunction of Retinal Ganglion Cells in Optic Neuropathies
Creator
Drenushe Krasniqi; Madhura Shah; Margarete Karg; Yuancheng Lu; David Sinclair; Bruce Ksander; Joseph Rizzo
Affiliation
(DK) (MK) (BK) Schepens Eye Research Institute/ Mass. Eye and Ear; (MS) Massachusetts Eye and Ear; (YL) Sinclair Lab, Harvard Medical School; (DS) Harvard Medical School; (JR) Massachussets Eye and Ear
Subject
Optic Nerve Trauma and Treatment; Optic Neuropathy
Description
NAION (Non-Arteritic Anterior Ischemic Optic Neuropathy) and glaucoma are optic neuropathies with different pathophysiology but a common endpoint, the apoptosis of retinal ganglion cells (RGCs).
Date
2023-03
References
Lu, Brommer, Tian... Ksander, Sinclair et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020;588(7836):124-129. doi:10.1038/s41586-020-2975-4 Al Aboud , Tupper, Jialal. Genetics, Epigenetic Mechanism. [Updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK532999/ Hamilton. Epigenetics: principles and practice. Dig Dis. 2011;29(2):130-5. doi: 10.1159/000323874. Epub 2011 Jul 5. PMID: 21734376; PMCID: PMC3134032.
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
2023 North American Neuro-Ophthalmology Society Annual Meeting
