Effect of Prostaglandin Analogs on Cerebrospinal Fluid Reabsorption Via Nasal Mucosa

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Identifier 20210221_nanos_journalclub1_07-abstract
Title Effect of Prostaglandin Analogs on Cerebrospinal Fluid Reabsorption Via Nasal Mucosa
Creator Prem S. Subramanian, Michelle G. Pedler, J. Mark Petrash
Affiliation (PSS) (MGP) (JMP) Sue Anschutz-Rodgers UCHealth Eye Center/University of Colorado School of Medicine, Aurora, CO
Subject High Intracranial Pressure/Headache; Pseudotumor Cerebri
Description Cerebrospinal fluid (CSF) outflow has been demonstrated along nasal lymphatics via olfactory nerve projections; flow may be increased by stimulating lymphatic contractility using agents such as noradrenaline and the thromboxane A2 analog U46619. Lymphatics elsewhere in the body show increased contractility upon exposure to the prostaglandin F2alpha analog isoprostane-8- epi-prostaglandin. We investigated the ability of ophthalmic prostaglandin F2alpha analogs to increase CSF outflow when applied to the nasal mucosa by inhalation.
Date 2021-02
Language eng
Format application/pdf
Type Text
Source 2021 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS Annual Meeting 2021: Journal Club: What You Need to Know Now!
Collection Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2021. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6ns6ssf
Setname ehsl_novel_nam
ID 1694264
Reference URL https://collections.lib.utah.edu/ark:/87278/s6ns6ssf