Identifier |
20190318_nanos_hottopic1_03_slides |
Title |
MOG-IgG Optic Neuritis (Slides) |
Creator |
John Chen, MD, PhD |
Affiliation |
Mayo Clinic, Rochester, MN |
Subject |
Myelin Oligodendrocyte Glycoprotein (MOG)-IgG; Optic Neuritis; Chronic Relapsing Inflammatory Optic Neuropathy; Neuromyelitis Optica Spectrum Disorder (NMOSD); Demyelinating Disease |
Description |
Optic neuritis is the most common cause of optic neuropathy in young patients, which can cause debilitating vision loss and blindness. Two novel glial autoantibodies have been discovered that better characterize a subset of patients with optic neuritis. In 2004, antibodies against an astrocytic water channel, aquaporin-4 (AQP4) were discovered, which greatly improved our understanding and detection of the clinical entity neuromyelitis optica spectrum disorders (NMOSD). More recently, antibodies specific for myelin oligodendrocyte glycoprotein (MOG-IgG), have been found in a subset of patients with optic neuritis and other demyelinating phenotypes. Although initially erroneously associated with multiple sclerosis in early literature with use of solid-phase assays, newer live transfected cell-based assays have shown MOG-IgG to be a reproducible marker for a subset of patients with optic neuritis, AQP4-IgG seronegative inflammatory CNS demyelinating disorders with NMOSD-like phenotype, and acute disseminated encephalomyelitis (ADEM). |
Date |
2019-03 |
Language |
eng |
Format |
application/pdf |
Format Creation |
Microsoft PowerPoint |
Type |
Text |
Source |
2019 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2019: Hot Topics: How Do I Treat? |
Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
Publisher |
North American Neuro-Ophthalmology Society |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2019. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6k12cz0 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1539067 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6k12cz0 |