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Show LIILI\i\TURf ABSTRACTS Childhood Chiasmal Gliomas: Update on the Fate of Patients in the 1969 San Francisco Study. In1('s R". Hoyt WF. Hr/l)/,/,1!1I1111/ol IYHh;70:17Y-H2 (Mar). II\l'print rt'ljul'S!s tll W. F. Iloy!, M.D., ROlllll M-H7/l. J)q',lrtnll'nt lit l )phth,lll1l11l11gV. Uni\' ersil\' of C,llifllrni,l, S,lll h,lllCisCll, San Frilnciscll, C/\ lJ-lI-lJ.1 This is ,1 review of the current status of 2H piltients wllll presl'nll'd with chiasmill glioma 'lnd who were rl'portL'd in )YhY by Hoyt and Baghdass, uian. This repllrt represents the longest followup n.'view of p,ltil'nts with chiasmal glioma yet repl1rted the med ium follow-u p period bei ng 20 years from diagnosis. Sixteen of 28 patients are dead. Howl'ver, only five of them died from their chiasmaI glioma. Four of the deaths from chiasmal glioma occurred within 3 years of diagnosis; this emphasizes that the risk of death from these lesions is greatest during the early follow-up period. Patients with neurofibromatosis may be at greater risk of death from nonchiasmal tumor than from their chiasmal glioma. Apparently, visual function of affected patients has not changed appreciably since diagnosis. Except for hypothalamic effects on growth and body habitus, most of the surviving reported patients are considered normal, and seem to be well adjusted in their life socially. However, prognosis for survival in patients with chiasmal glioma is felt to be not as good as it was thought to be in 1969. Al'illoam B. Safrall, M.D. Mydriatic Response to Topical Naloxone in Opiate Abuse. Ghobse AH, Bewley TH, Kearney MK, Smith SE. Br I Psychiatry 1986;148:44-6 (Jan). [Reprint requests to S. E. Smith, Department of Applied Pharmacology and Therapeutics, St. Thomas Hospital Medical SchooL UMDS, London SE1, 7EH, England]. Use of naloxone eyedrops may be a diagnostic test of current opioid effects, and possibly of physical dependence. In 36 of 47 opiate addicts on methadone maintenance treatment, naloxone hydrochloride eyedrops (1 mg/ml) dilated the pupilS. This effect was not seen in healthy unmedicated subjects. In addicts, response was attenuated by certain ancillary treatments and by withdrawal of methadone treatment. Al'illoam B. Safrall, M.D. I Cl1II NCIITll-(l/,llllm!lI/ol. V"t 6. No.4. 1980 Oculographic Diagnosis of Hemineglect in Patients with Homonymous Hemianopia. Meienberg 0, Harrer M, Wehren C. I Neural 1986; 233:97-101 (Jan). [Reprint requests to Dr. 0. Meienberg, Neurologische UniversiUitsklinik, Kantonsspital, CH-4031 Basel, Switzerland.] Patients with hemineglect demonstrate no or only few spontaneous searching saccades crossing the midline, no reaction after disappearance of fixated target, inefficient searching saccades on command, no prediction of target, missing part of lines upon reading, and no or insufficient pursuit of target towards the hemineglected side. This is in contrast with the ocular motor pattern occurring in patients with isolated homonymous hemianopia who demonstrate many spontaneous saccades crossing the midline, immediate reaction with searching movements upon disappearance of fixated target, prediction of target, some initial difficulties in finding beginning of lines with left hemianopia, increased number of reading steps when reading with right hemianopia, and finally ability of target pursuit to extreme positions, including onhemianopic side. Importance of electrooculographic recording was emphasized in the paper of Meienberg et al. for diagnosing hemineglect in patients showing hemianopia, with objective and quantitative methods. Al'illOl1!1l B. Safrall, M.D. Peripheral Neuropathy Associated with the Sicca Syndrome. Kennett RP, Harding AE. I Nt'llrol Neurtlsllrs Psychiatry 1986;-19:90-2 (Jan). [Reprint requests to Dr. R. Kennett, Department of Clinical Neurology, Institute of Neurology, Queen Square, London, WClN 3BG, England]. In case of chronic sensory axonal neuropathy, particularly when proprioceptive loss is prominent and pupillary abnormalities as well as trigeminal involvment are present, investigations should include autoantibody studies and salivary gland bIOPSY, This was indicated in a study of three patients with the sicca syndrome, and demonstrating chrome sensory neuropathy. In two of them, neuropathy was the presenting clinical feature of the disorder. Sensory impairment in the trigeminal nerve territory was noted in two patients. These two patients also showed tonic pupils, with evidence of parasympathetic denervation. All three reported patients suffered from chronic peripheral |