Spontaneous Hyperactivity Emerges Before Light Responsiveness is Lost During Retinal Degeneration in rd10 Mice

I previously reported that both spontaneous and light-evoked ganglion cell activity are substantially altered as photoreceptors degenerate in the rd1 mouse model of retinitis pigmentosa, suggesting significant reorganization of inner retinal circuitry. In the closely related rd10 mouse degeneration progresses more slowly, so loss of photoreceptors begins only after a peak of developmental changes in retinal circuitry.