Juvenile Nasopharyngeal Angiofibroma with Intracranial Extension (.pdf)

Juvenile nasopharyngeal angiofibroma (JNA), the most common benign tumor of the nasopharynx, accounts for 0.5% of all head and neck neoplasms.This vascular tumor is found in adolescent males. Its aggressive local growth may lead to paranasal sinus, orbital and intracranial extension, even without detectable clinical signs and symptoms. Ocular findings are uncommon. Exophthalmos (14%), decreased vision (5%) partial ophthalmoplegia (2%), and facial deformities were reported. Diagnosis is based on clinical findings and neuroimaging. Pre-operative angiography should be routinely performed, and tumor feeder vessels embolized before tumor resection.Treatment of choice is surgical excision, combined with radiotherapy in large tumors. Cure ranges between 70 and 100%. (2,4). Follow-up is mandatory due to high relapse rate.