Kinetics of neutrophils and hematopoietic progenitor cells in rats infected with E. Coli

The effects of bacterial infection on neutrophil kinetics have been studies for many years. This study measured the effects of a sub-lethal infection with E. Coli on the neutrophil storage pool (NSP), neutrophil proliferative pool (NPP), immature to total neutrophil (I/T) ratio, absolute neutrophil count (ANC), and the number and proliferatifve rates of colony forming unit granulocyte, erythrocyte, megakaryocyte, monocyte (CFU-GEMM), colony forming gunit granulocyte, monocyte (CDU-GM), and colony forming unit erythrocyte (CFU-E) in rats. During infection while the NSP and NPP were decreased, the I/T ratio and ANC were increased. This study also measured the number and poliferative rates on all three progenitor cells during infection.