A New Pupil Light Reflex Test for Detecting Optic Neuropathy Independent of the Fellow Eye Which Highly Correlates to Visual Field Volume

Introduction: Our purpose was to develop and test a new paradigm for detecting optic nerve disease in one eye, independent of the fellow eye, so that patients with bilateral involvement can be diagnosed and monitored using objective pupil responses. We also sought to determine which stimulus light condition and pupil response parameter (transient vs. sustained contraction) would provide the greatest difference between normal and abnormal eyes and the highest correlation with visual field sensitivity.