Opsoclonus-Myoclonus Syndrome in Primary Central Nervous System Lymphoma

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Title Opsoclonus-Myoclonus Syndrome in Primary Central Nervous System Lymphoma
Creator Joseph Grubbs Jr, MD, MPH, Jonathan D. Trobe, MD, Amanda Fisher-Hubbard, MD
Affiliation Departments of Ophthalmology and Visual Sciences (JG, JDT), Neurology (JDT) and Pathology (Neuropathology) (AFH), Kellogg Eye Center, University of Michigan Medical System, Ann Arbor, Michigan
Subject Biopsy; Brain; Brain Neoplasms; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Magnetic Resonance Imaging; Middle Aged; Opsoclonus-Myoclonus Syndrome; Tomography, X-Ray Computed
Abstract Adult-onset opsoclonus-myoclonus syndrome (OMS) has been associated with multiple cancers, most commonly small-cell lung carcinoma and breast adenocarcinoma. A 53-year-old woman who presented with OMS was found to have primary central nervous system (CNS) diffuse large B-cell lymphoma. OMS has been described in only 5 cases with non-Hodgkin lymphoma (NHL), and this is only the third reported case of OMS in NHL limited to the CNS. Although the paraneoplastic antibody panel was negative, we presume that the OMS was a paraneoplastic manifestation. Antineoplastic and anti-immune therapy had no effect on the neurologic manifestations.
OCR Text Show
Publisher Lippincott, Williams & Wilkins
Date 2016-12
Type Text
Source Journal of Neuro-Ophthalmology, December 2016, Volume 36, Issue 4
Language eng
Rights Management © North American Neuro-Ophthalmology Society
Publication Type Journal Article
ARK ark:/87278/s6cp12dd
Setname ehsl_novel_jno
Date Created 2018-01-24
Date Modified 2020-03-17
ID 1293155
Reference URL https://collections.lib.utah.edu/ark:/87278/s6cp12dd