| Title |
Tacrolimus Optic Neuropathy |
| Creator |
Nailyn Rasool, MD, FRCPC; Katherine Boudreault, MD, FRCSC; Simmons Lessell, MD; Sashank Prasad, MD; Dean M. Cestari, MD |
| Affiliation |
Department of Ophthalmology (NR), Harkness Eye Institute, Columbia University, New York, New York; Deartment of Ophthalmology (KB), University of Montreal, Montreal, Quebec, Canada; Department of Ophthalmology (SL, DMC), Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts; and Department of Ophthalmology (SP), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts |
| Abstract |
Tacrolimus (FK506, Prograf) is a potent immunosuppressant, which inhibits cytokine synthesis and blocks T-cell development. Optic neuropathy from tacrolimus toxicity is very uncommon but, when present, can result in severe vision loss. Case series and review of the literature. We present 3 patients with tacrolimus optic neuropathy after bone marrow transplantation complicated by graft-vs-host disease and demonstrate the differing clinical and radiologic presentation of this presumed toxic optic neuropathy. Tacrolimus optic neuropathy can manifest in a multitude of clinical presentations and can have devastating visual consequences. |
| Subject |
Older people; Bone Marrow Transplantation; Cerebrospinal Fluid; Graft vs Host Disease; Humans; Immunosuppressive Agents; Leukocytosis; Lymphocytes; Magnetic Resonance Imaging; Male; Middle Older people; Optic Disk; Optic Nerve Diseases; Tacrolimus; Visual Acuity; Visual Field Tests; Visual Fields |
| Date |
2018-06 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Publication Type |
Journal Article |
| Source |
Journal of Neuro-Ophthalmology, June 2018, Volume 38, Issue 2 |
| Collection |
Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/ |
| Publisher |
Lippincott, Williams & Wilkins |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
© North American Neuro-Ophthalmology Society |
| ARK |
ark:/87278/s6c5865d |
| Setname |
ehsl_novel_jno |
| ID |
1452583 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6c5865d |
