Regional MRI Abnormalities and Visual Dysfunction in Patients with Multiple Sclerosis

Measures of low-contrast letter acuity best capture visual dysfunction in patients with multiple sclerosis (MS). Although conventional MRI parameters have shown modest correlations with neurological disability, newer MRI methods may be superior in reflecting specific dimensions of disease in MS, including vision. Our objective was to determine the relation between whole brain MRI abnormalities and visual function in MS, and to determine whether regional abnormalities within the visual system are more predictive of visual outcomes.