Heparan sulfates in the terminal sac period of the lung (mouse, fetus)

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Title Heparan sulfates in the terminal sac period of the lung (mouse, fetus)
Creator Poels, Lambert G.
Contributor Lambert G. Poels, PhD, UMC St Radboud Nijmegen; Paul H. K. Jap, PhD, UMC St Radboud Nijmegen
Date 2006-09-28
Subject Bronchioli; Air spaces; Terminal sac period
Description Stain: fluorescence microscopy with anti-heparan sulphate antibody (a phage-display antibody, HS4E4). Heparan sulfates are linear polysaccharides that belong to the group of the glycosaminoglycans (GAGs). These GAGs are found associated with basement membranes as shown here. The sulphated saccharide domains provide numerous docking sites for protein ligands. Strong fluorescence visualizes the course of all basement membranes, especially around the bronchioles (B), subendothelially within the pulmonary artery (PA) and small branches. The lining of the air spaces (A) and capillaries within the thick septa (with non-inflatable alveoli) are also well-stained. Note negative reacting lymph vessels (Lv) (no basement membrane). GAG expression changes during tumor development.
Subtype Image
Format image/jpeg
Rights http://creativecommons.org/licenses/by-nc-nd/2.5/
Collection Poja Histology Collection - Respiratory System Subset
ARK ark:/87278/s6bc71t7
Setname ehsl_heal
Date Created 2012-12-11
Date Modified 2012-12-11
ID 890671
Reference URL https://collections.lib.utah.edu/ark:/87278/s6bc71t7