Impact of Glucose on Mitochondrial Function in a Brain Slice Model of Headache Mechanisms
Creator
Olivia Grech; Daniel Fulton; Zerin Alimajstorovic; Silke Heising; David Cartwright; Susan Mollan; Gareth Lavery; Alexandra Sinclair
Affiliation
(OG) (ZA) (SH) (DC) (GL) (AS) Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland; (DF) Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom of Great Britain and Northern Ireland; (SM) Birmingham Neuro-Ophthalmology, Queen Elizabeth Hospital, Birmingham, United Kingdom of Great Britain and Northern Ireland
Subject
High Intracranial Pressure/Headache; Pseudotumor Cerebri
Description
Idiopathic intracranial hypertension (IIH) is a condition of raised intracranial pressure that features debilitating headaches with migraine-like characteristics. Cortical Spreading Depression (CSD), a propagating wave of depolarisation across the cerebral cortex, proposed to activate trigeminal nerve afferents and contribute to headache pathophysiology. Fasting is noted to trigger and aggravate headache attacks, therefore using a mouse brain slice model, we aimed to investigated the impact of hypoglycaemia and CSD on mitochondrial and metabolic function.
Date
2022-02
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
2022 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of
NANOS Annual Meeting 2022: Scientific Platform Session II