Identifier |
20150222_nanos_posters_069 |
Title |
How does Exogenous ROS Effect LHON Conversion |
Creator |
Jeffrey Tran; Youning Zhang; Rustum Karanjia; Chiara La Morgia; Solange R. Salomao; Adriana Berezovsky; Filipe Chicani; Milton Moraes; Milton M. Filho; Rubens Belford Jr.; Alfredo A. Sadun; Valerio Carelli |
Affiliation |
(JT) (YZ) Keck School of Medicine of University of Southern California, Los Angeles, CA; (RK) (AA) Doheny Eye Institute, UCLA, Los Angeles, CA; (CL) (VC) IRCCS Istituto delle Scienze Neurologiche di Bologna, Bellaria Hospital, Bologna, Italy; (CL) (VC) Neurology unit, Department of Biomedical and NeuroMotor Sciences (DIBINEM), University of Bologna Bologna, Italy; (SRS) (AB) (MM) (MMF) (RB) Department of Ophthalmology, Federal University of Sao Paulo (UNIFESP) Sao Paulo, Brazil |
Subject |
Genetic Disease; Optic Neuropathy |
Description |
Mitochondrial DNA mutations associated with Leber's hereditary optic neuropathy (LHON) are associated with endogenous reactive oxygen species (ROS) production. Research has demonstrated that exogenous ROS generators, like smoking, are associated with an earlier age of conversion from carrier to affected state. However, the exact role of exogenous ROS in LHON is ill defined. To understand the role of exogenous ROS in LHON, we hypothesize dividing LHON into two subtypes. I: conversion is predominantly genetically determined and largely independent of exogenous ROS and II: the genetic component is necessary but insufficient for conversion and exogenous ROS exposure is required. |
Date |
2015-02-22 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2015 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2015: Poster Presentations |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s69w3nbr |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
184508 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s69w3nbr |