Clinical, Functional and Cellular Responses in a Novel Primate Model of Nonarteritic Anterior Ischemic Optic Neuropathy (PNAION)

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Identifier 20070213_nanos_sciplatform_14.pdf
Title Clinical, Functional and Cellular Responses in a Novel Primate Model of Nonarteritic Anterior Ischemic Optic Neuropathy (PNAION)
Creator Celia Chen; Mary Johnson; Bernard Slater; Neil Miller; Steven Bernstein
Affiliation (CC) (NM) (SB) Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore MD; (MJ) (BS) University of Maryland School of Medicine, Baltimore MD
Subject Non-arteritic Anterior Ischemic Optic Neuropathy; Primate Model; Electrophysiology; Histopathology; Optic Nerve
Description Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of sudden optic nerve-related vision loss in adults. NAION affects more than 26,000 Americans every year and there are no effective treatments to date. A rodent model of NAION (rAION) has been developed but a primate model is crucial to define the pathophysiological changes that result from sudden ischemia in the highly structured human optic nerve and to develop neuroprotective strategies for this disease. We wanted to determine if NAION can be induced in non-human primates (pNAION) and to identify the optimal induction parameters for pNAION.
Date 2007-02-13
Language eng
Format application/pdf
Type Text
Source 2007 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS 2007: Scientific Platform Presentations (Session II)
Collection Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2010. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6894c96
Setname ehsl_novel_nam
ID 180948
Reference URL https://collections.lib.utah.edu/ark:/87278/s6894c96