High altitude-associated non-arteritic anterior ischemic optic neuropathy (NAION) [1-3] typically occurs in younger patients who have disc-at-risk and few other risk factors [4-9], raising the possibility that hypobaric hypoxia may be the tipping point of vision loss. In this study, we investigated the effects of systemic hypoxia on the retina and optic nerve and assessed the therapeutic potential of pre-treatment with chemical chaperon 4-phenylbutyric acid (4- PBA), which reduces endoplasmic reticulum (ER) stress.
Date
2019-03
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
2019 North American Neuro-Ophthalmology Society Annual Meeting