Identifier |
20080311_nanos_posters_013.pdf |
Title |
Amyloid-B and Glaucoma: The Retinal Ganglion Cell- Neurotoxic Connection |
Creator |
Deborah M. Grzvbowski; Allred Clint; John Donahue; Shelley A Glimcher; William Lawhon; Conrad Johanson; Edward G. Stopa |
Affiliation |
(DMG) (AC) (SAG) (WL) The Ohio State University, Columbus, Ohio; (JD) (CJ) (EGS) Brown University School of Medicine, Providence, Rhode Island |
Subject |
Amyloid Beta, Glaucoma, Arachnoid Membrane, Neurotoxic, CSF Clearance |
Description |
It has been shown that amyloid-P colocalizes with retinal ganglion cells (RGC) that are apoprotic. Glaucoma patients have been shown to have decreased vitreous amyloid-B (AB) levels, which is consistent with AB deposition in the retina.. Patients with Alzheimer's disease and Parkinson's disease, two chronic neurodegenerative diseases related to aging, have been shown to have RGC loss that is associated with cypical glaucomatous changes. We hypothesize that this neurotoxic component of glaucomatous damage is present in all patients who have retinal damage with RGC loss, and blocking that AB pathway will arrest a neurotoxic component ofglaucomatous visual loss. |
Date |
2008-03-11 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2008 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2008: Poster Presentations |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2010. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s60c823h |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
180834 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s60c823h |