The Use of Topological Data Analysis in Detecting Papilledema Using Oral Fluorescein Angiography in Children

Differentiating papilledema from psedopapilledema could be challenging, especially in the pediatric population. However, differentiating the two conditions is essential in avoiding unnecessary invasive procedures and testing. Multiple technologies have been used over time to improve accuracy. One easy and efficient technique that is gaining popularity is oral fluorescein angiography (FA). A previous study that used expert readers demonstrated lower than expected accuracy in diagnosing papilledema. This was due especially to lower specificity. On the other hand, intravenous FA was reported as being a valuable tool, but has the drawback of an invasive test poorly tolerated in children.