Identifier |
20170402_nanos_posters_033 |
Title |
Can occipital lesions produce pre-geniculate changes in humans? |
Creator |
Kimberly Gokoffski; Vivek Patel |
Affiliation |
(KG) (VP) USC Roski Eye Institute, Los Angeles, California |
Subject |
Stroke Trauma; Neuroimaging; Visual Fields; Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc); Eyelid & Adnexal Disease |
Description |
Retrograde trans-synaptic degeneration (RTSD) has been well documented in animal studies: occipital lobectomies in adult primates leads to atrophy of not only the lateral geniculate nucleus, but also that of the optic nerves (ON). Clinical observations in humans, however, have varied in support of this concept. In one case, five decades after a cerebral vascular accident that resulted in a homonymous hemianiopia, the ON showed no evidence of atrophy. In contrast, a case series of patients with retro-geniculate lesions showed correlating ganglion cell layer (GCL) loss via spectral domain-optical coherence tomography (SD-OCT) in 68% of patients. Although this discrepancy may, in part, be explained by the availability of higher resolution imaging allowing characterization and quantification of neuronal loss in the anterior visual pathway that was previously missed, there may be other undetermined structural or functional changes in the posterior visual pathway that influence which injuries lead to RTSD. |
Date |
2017 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2017 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2017: Poster Presentations |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
ARK |
ark:/87278/s6032kkz |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1272689 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6032kkz |