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1 A Neuro-Ophthalmologist's View of RGC Apoptosis and NeuroprotectionAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCSlide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma. Presen...Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma
2 AIDS: neuro-ophthalmologic manifestationsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCDiscusses various neuro-opthalmological complications to which AIDS patients are prone, and results of experimental testing on rabbits using Pentoxifylline. Anatomy: Optic nerve; Axons; Optic disk; Astrocytes; Macrophages. Pathology: Slides showing astrocytes, macrophages, cytokine staining. Disease...Optic nerve; Axons; Optic disk; Astrocytes; Macrophages; Infarction; Pneumocystis carinii; Acquired immunodeficiency syndrome; Cytomegalovirus retinitis; Retinal necrosis syndrome, Acute; Cryptococcus; Meningitis; Leukoencephalopathy, Progressive multifocal; Papilledema; AIDS dementia complex; Cellu...
3 Accreditation and the RRCAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA slide presentation providing information on accreditation and the residency review committee (RRC).Opthalmology; Medical Education
4 Acute Retrobulbar Optical NeuropathyAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPPT covering acute retrobulbar optic neuropathy, including ischemic, inflammatory, anterior ischemic optic neuropathy (AION) and non-arteritic anterior ischemic optic neuropathy (NAION); includes brainscan images for optic neuritis and multiple sclerosis; optic disk with LHON and PION. Anatomy: Opt...Optic Neuropathy, Ischemic; Giant Cell Arteritis; Edema; Multiple sclerosis; Optic Atrophy, Hereditary, Leber; Ischemia; Hypotension; Edema; Optic Neuritis; Optic Nerve; Interferon-Beta-1a; Diseases of the Optic Nerve
5 An Epidemic of Blindness in Cuba: Lessons on Nutrition and MitochondriaAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresented at Stanford in April 2007, recapping the 1990s expedition to Cuba to investigate causes of blindness epidemic. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ambliopia; Ataxia; Paresthesia; Hyporeflexia.Cuba; Castro, Fidel, 1926-; Folate; Optic Nerve; Optic Nerve Diseases; Alcoholic Neuropathy; Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia
6 Anatomy and Physiology of Vision: The Visual PathwaysAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCIntroduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn...Optic Nerve; Optic Disc; Retina; Retinal Ganglion Cells; Optic Chiasm; Visual Cortex; Pituitary Adenoma; Optic Atrophy; Anatomy of Visual Pathways; Afferent Visual Pathways
7 Anatomy and Physiology of the Optic NerveAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCLecture covering the anatomy and physiology of the optic nerve. Covers the retina and anterior visual pathways. Several slides show microscopic images of optic nerve damage. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma.Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma; Anatomy of the Optic Nerve; AVP Optic Nerve
8 Apoptosis in LHON: an ROS explanationAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA slide presentation describing apoptosis in LHON; includes several images of optic nerve and optic disk. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber.Optic Atrophy, Hereditary, Leber; Brazil; Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species; Apoptosis; Cell death; ROS1 protein, human
9 Apoptosis of Retinal Ganglion CellsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresented at a conference on neuroprotection at Sedona, Arizona, 2002; includes several microscopic images demonstrating cell death. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma.Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma
10 Are IV Steroids and Anti-Platelet Agents Indicated in Every Case of GCA?Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCFrom a debate at a meeting in Canada in Sept. 2006, with Sadun taking the "pro" position. Disease/Diagnosis: Giant cell arteritis. Treatment: Methylprednisolone Hemisuccinate; Solumedrol; Prednisone; Aspirin.Methylprednisolone Hemisuccinate; Solumedrol; Prednisone; Aspirin; Giant Cell Arteritis
11 Atypical Optic NeuropathiesAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA discussion of atypical optic neuropathies. Anatomy: Optic nerve; Optic disc. Pathology: Slides showing LHON. Disease/Diagnosis: Optic neuropathy, Ischemic; Optic atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Optic neuritis; Eye hemorrhage; Retinal vasculitis; Dyschromatop...Brazil; Cuba; Ethambutol; Optic Neuritis; Eye Hemorrhage; Retinal Vasculitis; Dyschromatopsia; Scotoma; Ataxia; Paresthesia; Hyporeflexia; Optic Nerve; Optic Disc; Optic Neuropathy, Ischemic; Optic Atrophy, Hereditary, Leber; Toxic Optic Neuropathy
12 Beyond Visual Acuity: New Measures in the Evaluation of VisionAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCUse of Amsler charts and 3-D computer imaging to evaluate visual acuity, sensitivity, and health. Disease/Diagnosis: Glaucoma; Age related macular degeneration. Presenting Symptom: Scotoma.Central Foveal Vision; Foveal Sensitivity; Visual Acuity; Amsler Chart Assessment; Scotoma; Glaucoma; Age Related Macular Degeneration; Perimetry; Campimetry
13 Beyond Visual Acuity: New Measures in the Evaluation of VisionAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCUse of Amsler charts and 3-D computer imaging to evaluate visual acuity, sensitivity, and health. Disease/Diagnosis: Glaucoma; Age related macular degeneration. Presenting Symptom: Scotoma.Central Foveal Vision; Foveal Sensitivity; Visual Acuity; Amsler Chart Assessment; Scotoma; Glaucoma; Age Related Macular Degeneration; Perimetry; Campimetry
14 Beyond the Margulis Hypothesis: The Time Bomb Within UsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresented at 36th Annual Doheny Days, 2005. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber.Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species
15 Beyond the Margulis Hypothesis: the Time Bomb Within UsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPresented at Harvard, 2005; includes several images of optic disc with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Dyschromatopsia; Scotoma.Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Dyschromatopsia; Scotoma
16 Circadian Rhythms: How Much Retina Do We Need for a Good Night's Sleep?Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCDiscusses importance of the health of the retinohypothalamic tract in the maintenance of circadian rhythm. Anatomy: Retina; Hypothalamus; Retinal ganglion cells; Pineal gland. Disease/Diagnosis: Retinal diseases; Sleep disorders, Circadian rhythm.Circadian Rhythm; Mole Rats; Retinal Diseases; Sleep Disorders; Retina; Hypothalamus; Retinal Ganglion Cells; Pineal Gland
17 Color Vision: Insights Into Our Origins and Some of Our Artists - From Darwin to DelacroixAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCDiscussion of origins and physiology of color vision in different species, distinction between addition and subtraction of colors, and how painters get around the difference. Includes microscopic views of retinal cones. Anatomy: Retina; Rods (Retina); Cones (Retina).Color Perception; Retina; Rods (Retina); Cones (Retina); AVP Association Areas
18 Compressive Optic Neuropathies PotpourriAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCAn overview of compressive optic neuropathies, including symptoms, varieties, testing, and treatments; slide presentation includes several neuroimaging scans. Anatomy: Optic nerve. Disease/Diagnosis: Compression of optic nerve. Treatment: MifepristoneOptic Nerve; Compression of Optic Nerve; Mifepristone
19 Controversies - Anatomy and Treatment of DyslexiaAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA slide presentation on dyslexia.Dyslexia
20 Cortical Visual Phenomena (Anton's to Geschwind's)Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPart 6 of a course taught at Stanford University. Anatomy: Visual cortex. Disease/Diagnosis: Aphasia; Blindness, Cortical; Hallucinations, Visual; Anton's Syndrome; Visual Agnosia; Palinopsia; Geschwind's Syndrome; Apraxia; Cortical paralysis of fixation syndrome; Alzheimer's Syndrome.Aphasia; Blindness, Cortical; Hallucinations, Visual; Anton's Syndrome; Visual Agnosia; Palinopsia; Geschwind's Syndrome; Apraxia; Cortical paralysis of fixation syndrome; Alzheimer's Syndrome; Visual cortex; Specialized Syndromes
21 Cuban Epidemic of Optic Neuopathy: Even Zealots Must Eat, or, Conversations with CastroAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA team of neuro-opthalmologists visits Cuba in 1993 and 1994, and attempts to treat patients with vision disorders. Anatomy: Optic nerve; Structure of cribriform plate. Disease/Diagnosis: Optic nerve diseases; Blindness; Ambliopia; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ataxia;...Cuba; Castro, Fidel, 1926- ; Folate; Optic nerve; Structure of cribriform plate; Optic nerve diseases; Alcoholic neuropathy; Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia
22 Cuban Epidemic of Optic Neuopathy: Even Zealots Must Eat, or, Conversations with CastroAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCA team of neuro-opthalmologists visits Cuba in 1993 and 1994, and attempts to treat patients with vision disorders. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia.Cuba; Castro, Fidel, 1926-; Folate; Optic nerve; Optic nerve diseases; Blindness; Ambliopia; Alcoholic neuropathy; Ataxia; Paresthesia; Hyporeflexia
23 Cushing and OphthalmologyAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCFrom a lecture at Yale in 2006, reviewing the life of Harvey Cushing, the founder of neurosurgery. Anatomy: Optic chiasm; Optic nerve. Disease/Diagnosis: Pituitary adenoma; Papilledema; X-linked hydrocephalus syndrome; Optic nerve glioma; Graves ophthalmopathy; Mucocele; Pituitary apoplexy; Optic ne...Cushing, Harvey, 1869-1939; Neurosurgery; Optic chiasm; Optic nerve; Proptosis; Dplopia; Ptosis; Hemianopsia; Pituitary adenoma; Papilledema; X-linked hydrocephalus syndrome; Optic nerve glioma; Graves ophthalmopathy; Mucocele; Pituitary apoplexy; Optic nerve atrophy; Neurosurgery; Decompression, Su...
24 Distinguishing Optic Nerve vs. Retinal LesionsAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPPT describing methods of distinguishing optic nerve verses retinal lesions. Describes a pateint case. Discussed signs, symtpoms and diagnostic tests. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; A...Optic Nerve Diseases; Retinal Lesion; Disorder of the Optic Nerve; Macular Lesion; Retinal Macula; Afferent Pupillary Defect; Scotoma; Optic Neuritis; Hyperopia; Metamorphopsia; Optic Nerve; Retina; Diseases of the Optic Nerve
25 Distinguishing an Optic Neuropathy from a MaculopathyAlfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor of Ophthalmology and Neurological Surgery, Keck School of Medicine at USCPPT describing a case of optic neuropathy. Covers signs and symptoms, and various laboratory tests. Describes 10 signes of disc edema. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; Afferent pupillar...Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; Afferent pupillary defect; Edema; Optic nerve; Retina; Retinal macula; Scotoma; Optic neuritis; Hyperopia; Metamorphopsia; Diseases of the Optic Nerve
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