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176 Ocular Myasthenia Gravis - How Effective Is Low Dose Prednisone Long Term?Ocular myasthenia gravis (OMG) therapy should address three issues - restoration of normal binocular vision. prevention of deterioration to generalize MG (GMG), and avoiding significant adverse effects of treatment. Prior studies suggest that moderate dose followed by low dose daily prednisone can a...Myasthenia, Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Ocular MotilityNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
177 Treatment Outcome in Ocular Myasthenia GravisOcular Myasthenia Gravis (OMG) is an autoimmune disease that affects the neuro-muscular junction resulting in ptosis and/or diplopia without general or bulbar symptoms. OMG patients can suffer from disabling ocular symptoms. The outcome of treatment with OMG is poorly understood. Our aim is to asse...Myasthenia, Ocular Motility, Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc), Eyelid & Adnexal Disease, Adult Strabismus with a Focus on DiplopiaNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
178 Horizontal Diplopia and Left Side Cranial Nerve PalsiesAbducens Nerve Diseases; Facial Nerve Diseases; Ophthalmoplegia; Diplopia; Blepharoptosis; Pupil Disorders; Myasthenia GravisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
179 Mycophenolate Mofetil as First-Line Therapy for Ocular Myasthenia GravisOcular myasthenia gravis (OMG) may produce debilitating diplopia or ptosis leading to significant visual disability. Symptomatic treatment with pyridostigmine is frequently ineffective and immunosuppressive therapy with corticosteroids can have serious side-effects.Myasthenia; MycophenolateNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
180 Ocular Myasthenia GravisA man with limited ocular excursions and only small amplitude saccades, improves with Tensilon, this illustrates the need to always consider ocular myasthenia in the differential diagnosis in patients with limited eye movements. Rapid restricted saccades, as this patient demonstrates, are diagnosti...Ocular Myasthenia GravisNeuro-Ophthalmology Virtual Education Library: Robert B. Daroff Collection https://novel.utah.edu/Daroff/
181 Ocular Myasthenia in ChildhoodClinical Signs: conspicuous limitation of eye movements in all directions. 3 year old girl with mild ptosis who developed ophthalmoplegia after a febrile episode; no systemic manifestations of myasthenia. Disease/ Diagnosis: Myasthenia Gravis; Blepharoptosis; Ophthalmoplegia.Myasthenia Gravis; Eye Movement Recordings; Lid Twitch; PtosisNeuro-Ophthalmology Virtual Education Library: David G. Cogan Collection https://novel.utah.edu/Cogan/
182 Pediatric Neuromuscular Disorders (Slides)Disruption of the neuromuscular transmission, either at the presynaptic or postsynaptic junction, may result in fatigability and muscle weakness that commonly affect ocular motility and lid movement. We will review several of the pediatric disorders that influence neuromuscular transmission.Pediatric Myasthenia Gravis; Congenital Myasthenia Gravis; BotulismNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
183 Pediatric Neuromuscular Disorders (Video)Disruption of the neuromuscular transmission, either at the presynaptic or postsynaptic junction, may result in fatigability and muscle weakness that commonly affect ocular motility and lid movement. We will review several of the pediatric disorders that influence neuromuscular transmission.Pediatric Myasthenia Gravis; Congenital Myasthenia Gravis; BotulismNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
184 Safety of Prednisone for Ocular Myasthenia GravisTreatment with chronic corticosteroids has been associated with frequent significant adverse effects. We hypothesized that the major side effect profile of a long-term, low-dose prednisone regimen for OMG was low.ocular myasthenia gravis; prednisone; clinical trials; safetyNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
185 Immune Checkpoint Inhibitor-Induced Ptosis in a Patient With Prostate CancerAdenocarcinoma / drug therapy; Aged; Blepharoptosis / chemically induced; Drug Therapy, Combination / adverse effects; Humans; Immune Checkpoint Inhibitors / adverse effects; Immune Checkpoint Inhibitors / therapeutic use; Ipilimumab / adverse effects; Ipilimumab / therapeutic use; Male; Nivolumab /...
186 Never Too Young or Too OldNeuromyelitis Optica Spectrum Disorder (NMOSD); Myasthenia Gravis; Optic Chiasm; Optic NeuritisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
187 Ocular Myasthenia Gravis: Toward a Risk of Generalization Score and Sample Size Calculation for a Randomized Controlled Trial of Disease ModificationBiopsy; Blepharoptosis; Diagnosis, Differential; Diplopia; Female; Humans; Magnetic Resonance Imaging; Middle Older people; Oculomotor Muscles; Ophthalmoplegia, Chronic Progressive External; SaccadesNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
188 Ocular Myasthenia Gravis Associated With Thymic AmyloidosisAmyloidosis; Autoantibodies; Blepharoptosis; Diplopia; Female; Glucocorticoids; Humans; Lymphatic Diseases; Magnetic Resonance Imaging; Middle Older people; Myasthenia Gravis; Receptors, Cholinergic; Thymectomy; Thymus GlandNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
189 A Case of Silent Sinus Syndrome Caused by a Dacryocystorhinostomy Presenting as Myasthenia GravisSilent Sinus Syndrome (SSS) is a rare entity defined as spontaneous, progressive enophthalmos and hypoglobus from maxillary sinus hypoplasia due to chronic maxillary sinus obstruction1. We present a unique case of silent sinus syndrome caused by a dacryocystorhinostomy presenting as myasthenia gravi...Silent Sinus Syndrome; Maxillary Sinus Hypoplasia; Dacryocystorhinostomy; Hypoglobus; DiplopiaNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
190 The Effects of Edrophonium on Eyelid SaccadesThe first diagnostic use of an anticholinesterase in myasthenia gravis included observations on its effect on ptosis. Subsequently, the response of myasthenic eye movements to edrophonium has been extensively studied with quantitative techniques. However, the effect of this drug on lid dynamics has ...Edrophonium; Eyelid Saccades; Myasthenia Gravis; PtosisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
191 Lid Twitch Sign in Myasthenia GravisClinical Signs: lid twitch sign on changing fixation from down gaze to primary in right eye. 28 year old woman with variable ptosis and ophthalmoplegia for 1 and a half years. Disease/ Diagnosis: Blepharoptosis; OphthalmoplegiaLid Twitch; Eye Movement RecordingsNeuro-Ophthalmology Virtual Education Library: David G. Cogan Collection https://novel.utah.edu/Cogan/
192 Peripheral Inflammatory Processes Affecting Ocular Motor FunctionMyasthenia gravis is a disorder of neuromuscular transmission. Normally, acetylcholine is packaged into vesicles which are then released into the cleft at the neuromuscular junction. Receptors bind the acetylcholine to initiate depolarization of the muscle membrane.Ocular Myasthenia Gravis; Thyroid Ophthalmology; Miller-Fisher Syndrome; Neuromuscular Transmission DiseaseNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
193 Pseudo-INOs in Myasthenia GravisThis is a 55-yo-woman with an intermittent exotropia who had normal adduction OU, but clear lag of adducting saccades OD>OS with rapid horizontal saccades. This was much more apparent after repeat testing (ie, it was fatigable), and she wound up having ocular MG.Myasthenia Gravis; INO; Abnormal SaccadesNeuro-Ophthalmology Virtual Education Library: Dan Gold Neuro-Ophthalmology Collection: https://novel.utah.edu/Gold/
194 Teenager with Acquired Strabismus: Do I Image? Do I Operate? (Video)Myasthenia gravis (MG) is an autoimmune disorder involving the neuromuscular junction of skeletal muscles. Adult and pediatric prevalence estimates are approximately 2-30 and 1-5 per million person years, respectively; 10-15% of all cases occur in children. Ocular findings include incomitant strabis...Strabismus; Myasthenia Gravis; Incomitant; Strabismus FixusNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
195 Clinical and subclinical oculomotor findings in the Eaton-Lambert syndrome.Older people; Blepharoptosis; Diagnosis, Differential; Electrooculography; Eye Movements; Female; Humans; Male; Middle Older people; Muscular Diseases; Myasthenia Gravis; Saccades; Visual Acuity
196 Chest CT Thymoma (Guest Lecture)The patient is a 46 year old woman who presented in July 1977 with horizontal double vision lasting two weeks. Three weeks later the left upper eyelid started to droop and by the end of the day the eye was closed. She had no ptosis of the right eye and no generalized fatigue. She consulted an intern...Unilateral Ptosis; Unilateral Lid Retraction; Myasthenic Lid Twitch; External Ophthalmoplegia; Ocular Myasthenia Gravis; Tensilon Test; Thymolipoma; Generalized Myasthenia Gravis; Unilateral Myasthenia Gravis; Myasthenic Ptosis; Lid Retraction; Lid TwitchNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
197 The Ice Pack Test For MyastheniaThe ice pack test is a simple, low-tech, bedside test that can readily be applied in the outpatient clinic or hospital setting, with minimal risk or discomfort. The ice pack test is used in patients with ptosis to help support or refute a diagnosis of myasthenia. We describe how to perform and int...Ice Pack Test; Ice Test; Myasthenia Gravis; Ocular Myasthenia; Ptosis; Diagnostic TestsNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
198 Hodgkin Lymphoma Diagnosed on Work-up for Ocular MyastheniaWe present a case of inferior rectus weakness with myasthenic features which led to a diagnosis of classic Hodgkin lymphoma.Myasthenia, Ocular Motility, Tumors, Neuro-ophth & systyemic disease ( eg. MS, MG, thyroid)Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
199 Quantification of Saccadic Fatigability for a Diagnosis of Myasthenia GravisSymptoms of myasthenia gravis (MG) are characterized by fatigable and fluctuating weakness with repeated use of muscle. The diagnosis of MG was combined with clinical symptoms and ancillary tests. However, each study has reported different sensitivity and specificity of the test, so there are variou...Myasthenia; Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid)Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
200 The Study of Extraocular Muscle in Ocular Myasthenia GravisMyasthenia gravis (MG) is a neuromuscular junction disorder that frequently affects the extraocular muscles. Atrophic extraocular muscles have been reported in a few cases with ocular MG. It has been observed particularly in chronic cases with treatment difficulties. A few pathological studies demon...Myasthenia; Ocular MotilityNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
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