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101 Origins and Regulation of Progenitor Cells in the Embyronic and Adult PancreasType I diabetes is caused by selective loss of insulin-producing β-cells. Identifying and activating an endogenous source of new β-cells could be used to replenish those lost in this disease. The nature and existence of an adult pancreatic stem/progenitor cell population, however, is still controv...2011-08
102 Genetic Analysis of Spontaneous Preterm BirthSpontaneous preterm birth (SPTB) is defined as birth before 37 completed weeks gestation that is not secondary to iatrogenic intervention. SPTB is both a pressing personal and public health issue that is not well understood. Previous studies have shown genetics as an important factor to SPTB. Here I...2013-12
103 The Multifunctional Protein Beta-Catenin and Pancreatic OrganogenesisDuring pancreatic organogenesis, all mature cell types in the pancreas arise from common multipotent pancreatic progenitor cells (MPCs), localized to the distal tip of the expanding epithelium. The dysfunction or destruction of pancreatic β-cells results in diabetes. Endeavors to treat this disease...2014-12
104 Molecular variation in the angiotensinogen gene and implications for essential hypertensionAdvances in the field of human genetics in the last four decades have enabled researchers to move from characterizing extremely rare diseases caused by gross chromosomal abnormalities to common diseases influenced by single base substitutions. The task now at hand is to investigate how subtle variat...Genetics1999-05
105 Molecular and genetic studies of the E75 early gene in DrosophilaThe steroid hormone, 20-hydroxyecdysone (20E), is responsible for initiating major developmental transitions in the fruit fly Drosophila melanogaster. Increases in the hormone titer induce a genetic cascade specific for the stage and tissue in which the increase occurs. Insights into these 20E induc...Puparium formation; Steroidogenic Enzymes2001-12
106 Molecular approaches to studying mammalian regenerationMammals have an extremely limited ability to replace damaged heart tissue. On a molecular level this irreversible tissue loss results from failure of cardiac myocytes to proliferate in response to an injury. As myocyte proliferation ceases shortly after birth, identification of genes expressed durin...2003-05
107 Pathologic and genetic characterization of two familial congenital heart defectsTotal anomalous pulmonary venous return (TAPVR) is a congenital heart defect in which the pulmonary veins fail to connect to the left atrium returning instead to the right atrium or one of its venous tributaries. Using linkage analysis in a large family with autosomal dominant transmission of TAPVR,...Total Anomalous Pulmonary Venous Return2000-05
108 Pleiotropic functions of Hox genes revealed by mutants for genes in Hox seventh and ninth paralogous groupsThe mammalian Hox complex consists of 39 genes that are believed to control the regionalization of the embryo along its major body axes. To investigate the in vivo functions of Hox genes, mice individually mutant for a subset of Hox genes were generated by gene-targeting. Mice with mutations in gene...Developmental; Analysis1998-08
109 Individual and collective roles of the 3' Hox genes in hindbrain and craniofacial developmentFollowing gastrulation, the vertebrate hindbrain is transiently segmented into 7 or 8 compartments termed rhombomeres. These compartments play a critical role in the organization of the motor and sensory components of the cranial nerves of the hindbrain. In addition, they are vital to the organizati...Developmental1999-08
110 Tools and Training for Genome Annotation and AnalysisThe MAKER genome annotation and curation software tool was developed in response to increased demand for genome annotation services, secondary to decreased genome sequencing costs. MAKER currently has over 1000 registered users throughout the world. This wide adoption of MAKER has uncovered the need...2015-12
111 Molecular and Cellular Regulation of Stem Cells During Muscle RegenerationSkeletal muscle is among the few adult tissues with the capacity to regenerate after injury. This is due to the resident stem cells within the muscle, the satellite cells. In the absence of injury, these stem cells remain quiescent and reside within their niche beneath the basement membrane adjacent...2012-12
112 Recombination-Mediated Mechanisms of Poxvirus EvolutionViruses undergo rapid genetic changes in response to selective forces imposed by host immune defenses. All organisms are at risk of virus infections, and the ancient and ongoing coevolution between viruses and their hosts have shaped genome evolution for both biological partners. One family of virus...2017-08
113 Genome Annotation and Genotype-Phenotype Association in Two Non-Model ParasitesWith the rapid proliferation of high-throughput sequencing methods, both the number and variety of genome assemblies have increased and require rigorous and sophisticated methods for genome annotation. As more species’ genomes are sequenced, the targets of genome annotation projects will more...2016-12
114 An Examination of Chiropteran HoxD Regulation from an Evolutionary PerspectiveHere we present our efforts to develop a model system that is suitable for laboratory experiments addressing Chiropteran development, genetics and evolution. The bat, Myotis lucifugus was selected as a model organism to study Chiropteran biology. To build a model system, Myotis lucifugus specimen...2008-05
115 To Motility and Beyond! Conserved Membrane Proteins in the Division and Differentiation of C. elegans SpermA cell's morphology plays an important role in its function. Thus, the size, shape, and structure of cells can be strikingly different across biology. In order to create this variation, cells must divide and differentiate in specific and regulated ways. In this dissertation, I describe work using C....Genetics; Developmental biology2018
116 Transcriptional Regulation of Xenobiotic Detoxification in DrosophilaXenobiotic compounds, such as pollutants, pesticides and other foreign chemicals, represent a constant threat to the survival of all organisms. To overcome this threat, animals mount an elaborate transcriptional response, regulating a battery of genes that provide detoxification and protective funct...2013-05
117 Genetic Analysis of Subcellular Branching in Drosophila Tracheal Terminal CellsAll cells have distinct cellular architectures that are critical for their function. A dramatic example of this relationship can be observed in cells that undergo subcellular branching. In this case, cells must first specify distinct branch sites and then outgrow cellular projections from those site...2013-12
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