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TitleDescriptionSubjectCollection
76 Ocular MyastheniaA disorder of neuromuscular transmission recognized clinically by varying muscle weakness which is characterized by worsening with fatigue.Ocular Myasthenia; Neuromuscular Transmission; Muscle Weakness; Ptosis; Diplopia; Myasthenia GravisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
77 Paradoxical Worsening of Myasthenic Ptosis after Ice TestTo report two patients with confirmed myasthenia gravis demonstrating paradoxical worsening of ptosis with initial IceTest.ice test; ptosis; myasthenia gravisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
78 Practical Demonstration of the Lancaster red-Green Test in Myasthenia GravisIn a multi-trauma victim if the surgeon even thinks about doing a tracheostomy, he should probably have already done it.Myasthenia Gravis;Lancaster Red-Green Test; Tracheostomy; Tensilon TestNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
79 Comparison of Clinical Characteristics and Treatment-Response in Early-and Late-Onset Ocular Myasthenia GravisOcular Myasthenia Gravis (OMG) is an autoimmune disease which causes ptosis, diplopia, or both. It can be categorized as early or late-onset, with differing presenting characteristics and prognosis based on previous studies. Currently, there is limited information compared characteristic and outcome...Myasthenia; Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid)Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
80 Cost-Related Barriers to Medication Adherence in Patients with Diplopia Secondary to Myasthenia GravisWe explored common cost-related barriers to medication adherence in patients with diplopia secondary to myasthenia gravis (MG) in a large national cohort.MyastheniaNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
81 Ocular Myasthenia Gravis - How Effective Is Low Dose Prednisone Long Term?Ocular myasthenia gravis (OMG) therapy should address three issues - restoration of normal binocular vision. prevention of deterioration to generalize MG (GMG), and avoiding significant adverse effects of treatment. Prior studies suggest that moderate dose followed by low dose daily prednisone can a...Myasthenia, Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Ocular MotilityNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
82 Treatment Outcome in Ocular Myasthenia GravisOcular Myasthenia Gravis (OMG) is an autoimmune disease that affects the neuro-muscular junction resulting in ptosis and/or diplopia without general or bulbar symptoms. OMG patients can suffer from disabling ocular symptoms. The outcome of treatment with OMG is poorly understood. Our aim is to asse...Myasthenia, Ocular Motility, Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc), Eyelid & Adnexal Disease, Adult Strabismus with a Focus on DiplopiaNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
83 Mycophenolate Mofetil as First-Line Therapy for Ocular Myasthenia GravisOcular myasthenia gravis (OMG) may produce debilitating diplopia or ptosis leading to significant visual disability. Symptomatic treatment with pyridostigmine is frequently ineffective and immunosuppressive therapy with corticosteroids can have serious side-effects.Myasthenia; MycophenolateNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
84 Pediatric Neuromuscular Disorders (Slides)Disruption of the neuromuscular transmission, either at the presynaptic or postsynaptic junction, may result in fatigability and muscle weakness that commonly affect ocular motility and lid movement. We will review several of the pediatric disorders that influence neuromuscular transmission.Pediatric Myasthenia Gravis; Congenital Myasthenia Gravis; BotulismNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
85 Pediatric Neuromuscular Disorders (Video)Disruption of the neuromuscular transmission, either at the presynaptic or postsynaptic junction, may result in fatigability and muscle weakness that commonly affect ocular motility and lid movement. We will review several of the pediatric disorders that influence neuromuscular transmission.Pediatric Myasthenia Gravis; Congenital Myasthenia Gravis; BotulismNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
86 Safety of Prednisone for Ocular Myasthenia GravisTreatment with chronic corticosteroids has been associated with frequent significant adverse effects. We hypothesized that the major side effect profile of a long-term, low-dose prednisone regimen for OMG was low.ocular myasthenia gravis; prednisone; clinical trials; safetyNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
87 A Case of Silent Sinus Syndrome Caused by a Dacryocystorhinostomy Presenting as Myasthenia GravisSilent Sinus Syndrome (SSS) is a rare entity defined as spontaneous, progressive enophthalmos and hypoglobus from maxillary sinus hypoplasia due to chronic maxillary sinus obstruction1. We present a unique case of silent sinus syndrome caused by a dacryocystorhinostomy presenting as myasthenia gravi...Silent Sinus Syndrome; Maxillary Sinus Hypoplasia; Dacryocystorhinostomy; Hypoglobus; DiplopiaNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
88 The Effects of Edrophonium on Eyelid SaccadesThe first diagnostic use of an anticholinesterase in myasthenia gravis included observations on its effect on ptosis. Subsequently, the response of myasthenic eye movements to edrophonium has been extensively studied with quantitative techniques. However, the effect of this drug on lid dynamics has ...Edrophonium; Eyelid Saccades; Myasthenia Gravis; PtosisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
89 Peripheral Inflammatory Processes Affecting Ocular Motor FunctionMyasthenia gravis is a disorder of neuromuscular transmission. Normally, acetylcholine is packaged into vesicles which are then released into the cleft at the neuromuscular junction. Receptors bind the acetylcholine to initiate depolarization of the muscle membrane.Ocular Myasthenia Gravis; Thyroid Ophthalmology; Miller-Fisher Syndrome; Neuromuscular Transmission DiseaseNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
90 Teenager with Acquired Strabismus: Do I Image? Do I Operate? (Video)Myasthenia gravis (MG) is an autoimmune disorder involving the neuromuscular junction of skeletal muscles. Adult and pediatric prevalence estimates are approximately 2-30 and 1-5 per million person years, respectively; 10-15% of all cases occur in children. Ocular findings include incomitant strabis...Strabismus; Myasthenia Gravis; Incomitant; Strabismus FixusNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
91 Hodgkin Lymphoma Diagnosed on Work-up for Ocular MyastheniaWe present a case of inferior rectus weakness with myasthenic features which led to a diagnosis of classic Hodgkin lymphoma.Myasthenia, Ocular Motility, Tumors, Neuro-ophth & systyemic disease ( eg. MS, MG, thyroid)Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
92 Quantification of Saccadic Fatigability for a Diagnosis of Myasthenia GravisSymptoms of myasthenia gravis (MG) are characterized by fatigable and fluctuating weakness with repeated use of muscle. The diagnosis of MG was combined with clinical symptoms and ancillary tests. However, each study has reported different sensitivity and specificity of the test, so there are variou...Myasthenia; Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid)Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
93 The Study of Extraocular Muscle in Ocular Myasthenia GravisMyasthenia gravis (MG) is a neuromuscular junction disorder that frequently affects the extraocular muscles. Atrophic extraocular muscles have been reported in a few cases with ocular MG. It has been observed particularly in chronic cases with treatment difficulties. A few pathological studies demon...Myasthenia; Ocular MotilityNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
94 Differences and Similarities Between Idiopathic Intracranial Hypertension, Ocular Myasthenia Gravis, Optic Neuritis, and Horner's In Children Vs. AdultsPediatric neuro-ophthalmology is more than just neuroophthalmology of little people. Compared with neuro-ophthalmology in adults, in the pediatric subspecialty the diseases are different, with greater emphases on congenital malformations and genetic disorders and less on vascular problems.Idiopathic Intracranial Hypertension (Pseudotumor Cerebri); Pediatric Optic Neuritis; Ocular Myasthenia Gravis; Horner's SyndromeNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
95 The Effect of Corticosteroids on the Progression of Ocular Myasthenia to Generalized MyastheniaIn previously published reports, 49% to 69% of patients with Ocular Myasthenia (OMG) will progress to Generalized Myasthenia Gravis (GMG without any medical intervention. Of the patients with only ocular manifestations at onset who later develop symptoms of generalized myasthenia, 60% to 80% will do...Corticosteroids; Ocular Myasthenia; Myasthenia; Generalized Myasthenia GravisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
96 Neuro-ophthalmic Manifestations of Checkpoint InhibitorsCheckpoint inhibitors, such as ipilimumab, nivolimumab, and pembrolizumab, have been reported to cause ophthalmic adverse events. While myasthenia gravis induced by these medications has been previously documented, other neuro-ophthalmic manifestations have been rarely reported. This study aims to i...Chemotherapy and Radiation Injury, Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid)Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
97 Concomitant Seropositive Ocular Myasthenia and Biopsy-Proven Temporal ArteritisOcular myasthenia gravis (OMG) and temporal arteritis (or giant cell arteritis, GCA) are autoimmune diseases that affect visual function. Although they can both occur alongside other autoimmune conditions, there are very few cases of co- existing OMG and GCA. We present a case of seropositive OMG wi...Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid); MyastheniaNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
98 Effect of Initial Prednisone Dosing on Ocular Myasthenia Control at 1 MonthOcular myasthenia gravis (OMG) is an autoimmune condition responsive to corticosteroids. Experts recommend corticosteroids as first line immunosuppressive treatment (1); however, no guidelines exist for initial dosing. Prior retrospective reports have suggested initial doses of 40-80 mg daily (2) bu...Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), MyastheniaNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
99 Treatment of Ocular Myasthenia Gravis (Slides)Myasthenia gravis is caused by pathogenic autoantibodies to the postsynaptic neuromuscular junction. Clinically, this may affect any of the skeletal muscles causing variable weakness, which worsens with continued muscle activity. Ocular myasthenia gravis (OMG) may affect the levator palpebrae superi...Ocular Myasthenia; Treatment; Therapy; Pyridostigmine; Corticosteroids; Thymectomy; Azathioprine; Mycophenolate MofetilNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
100 Ipilimumab-Related Orbital Inflammation and Hypophysitis in Patients with Metastatic Melanoma: A Brief Case SeriesIpilimumab is a monoclonal antibody directed against cytotoxic T-lymphocyte antigen-4 used for the treatment of metastatic melanoma. The most frequent adverse reactions associated with Ipilimumab have been autoimmune disorders, including enteritis, uveitis and arthritis. Myasthenia Gravis and hypoph...Ipilimumab; Cytotoxic T-lymphocyte Antigen-4; Metastatic Melanoma; Myasthenia Gravis; Hypophysitis; Bilateral Orbital Edema; Diplopia; Orbital InflammationNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
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