The Alfredo A. Sadun Neuro-Ophthalmology Collection: A Professor of Ophthalmology and Neurological Surgery at the USC Keck School of Medicine, Dr. Sadun with a team of researchers at the Doheny Eye Institute pioneered research in optic nerve dysfunction in patients with Alzheimer's disease. Contains his "100 best lectures." Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor Ophthalmology & Neurological Surgery, Doheny Eye Institute, Keck School of Medicine at USC.
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Filters: Collection: ehsl_novel_aas
| Title | Creator | Description | Subject | Imaging | ||
|---|---|---|---|---|---|---|
| 26 |
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Mitochondria and the RGC | Alfredo A. Sadun, MD, PhD | Discussion of various forms of mitrochondrial optic neuropathies and how to distinguish from toxic optic neuropathies, with examples from Cuba and Brazil. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia. Anatomy: Optic nerve; Optic disc; Retinal ganglion cells; Reactive oxyge... | Optic Nerve; Optic Disc; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Optic Atrophy; Autosomal Dominant; Optic Atrophy; Hereditary; Leber; Toxic Optic Neuropathy; Brazil; Cuba; Linezolid | |
| 27 |
 |
Neuro-Surgical Approaches to the Orbit | Alfredo A. Sadun, MD, PhD | Discusses specifics of various approaches to surgical treatment of lesions, including transcranial and transfrontal orbitotomies; neuroimagery scans from before and after operation for meningioma. Presenting Symptom: Proptosis. Anatomy: Orbit; Optic nerve sheath. Disease/Diagnosis: Meningioma; Heman... | Coloboma; Aplasia; Proptosis; Orbit; Optic Nerve Sheath; Meningioma; Hemangiopericytoma; Neurosurgery; Osteotomy | |
| 28 |
 |
Neuroprotection = Apoptosis of Retinal Ganglion Cells | Alfredo A. Sadun, MD, PhD | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Presenting Symptom: Blindness; Ischemia; Retinal detachment. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunod... | Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy; Hereditary; Leber; Acquired Immunodeficiency Syndrome | |
| 29 |
 |
Office Techniques for Detecting Optic Nerve Disease | Alfredo A. Sadun, MD, PhD | Demonstration of brightness sense testing and of computer-generated graphics for Amsler grid testing. Presenting Symptom: Scotoma; Metamorphopsia. Anatomy: Optic nerve; Retina; Macula lutea. Disease/Diagnosis: Glaucoma; Optic neuritis; Macular degeneration. | Color Vision; Glaucoma; Macular Degeneration; Optic Neuritis; Scotoma; Metamorphopsia; Optic Nerve; Retina; Macula Lutea | |
| 30 |
 |
Optic Nerve Regeneration | Alfredo A. Sadun, MD, PhD | A slide presentation with three sets of 3 views increasing magnification. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic neuropathy, Ischemic; Retrograde degeneration; Necrosis. Treatment: Cerestat; Aptiganel; Memantine; Riluzole. | Nerve Regeneration; Optic Nerve; Retina; Retrograde Degeneration; Necrosis; Apoptosis; Cell Death; Cerestat; Aptiganel; Memantine; Riluzole | |
| 31 |
 |
Optic Neuritis Treatment Trials | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve. Disease/Diagnosis: Optic neuritis; Multiple sclerosis. Treatment: Methylprednisolone; Prednisone; Solumedrol. | Optic Neuritis; Multiple Sclerosis; Optic Nerve; Methylprednisolone; Prednisone; Solumedrol | |
| 32 |
 |
Testing the Functional Patient | Alfredo A. Sadun, MD, PhD | Discusses testing to distinguish organic ailments from psychosomatic or willful simulation of symptoms. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic nerve diseases; Retinal degeneration; Hysteria | Malingering; Hysteria; Optic Nerve; Retina; Optic Nerve Diseases; Retinal Degeneration | |
| 33 |
 |
Viagra and Vision Loss: Does Sex Make You Blind? | Alfredo A. Sadun, MD, PhD | At a formal debate during a meeting in Canada in Sept. 2006, Sadun was assigned the role of arguing the case FOR a connection between taking phosphodiesterase 5 (PDE5) inhibitors and developing anterior ischemic optic neuropathy. Presenting Symptom: Hypotension. Anatomy: Optic nerve; Optic disc; Cyc... | Sildenafil; Vardenafil; Tadalafil; Viagra; Levitra; Cialis; Optic Neuropathy, Ischemic; Toxic Optic Neuropathy; Optic Nerve; Optic Disc; Cyclic Nucleotide Phosphodiesterases, Type 5; Hypotension | |
| 34 |
 |
Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Alfredo A. Sadun, MD, PhD | Presentation at Harvard in 2006, focussing on Leber's Heriditary Optic Neuropathy; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic nerve diseases; Optic Atrophy, Hereditary, Leber. Presenting Symptom:... | Scotoma; Dyschromatopsia; Ataxia; Hyporeflexia; Optic Nerve Diseases; Optic Atrophy, Hereditary, Leber; Cuba; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death; Ethambutol | |
| 35 |
 |
An Epidemic of Blindness in Cuba: Lessons on Nutrition and Mitochondria | Alfredo A. Sadun, MD, PhD | Presented at Stanford in April 2007, recapping the 1990s expedition to Cuba to investigate causes of blindness epidemic. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ambliopia; Ataxia; Paresthesia; Hyporeflexia. | Cuba; Castro, Fidel; Folate; Optic Nerve; Optic Nerve Diseases; Alcoholic Neuropathy; Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia | |
| 36 |
 |
Optic Nerve Sheath Decompression in the Management of Optic Neuropathies | Alfredo A. Sadun, MD, PhD | A slide presentation with several images of optic disc, normal and with edema. Anatomy: Optic nerve; Optic disc. Disease/Diagnosis: Optic neuropathy, Ischemic; Pseudotumor cerebri; Papilledema. Treatment: Decompression, Surgical. | Decompression, Surgical; Optic Neuropathy, Ischemic; Pseudotumor Cerebri; Papilledema; Optic Nerve; Optic Disc | |
| 37 |
 |
Leber's Hereditary Optic Neuropathy: New Lessons From a Giant Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Optic Atrophy, Hereditary, Leber; Blindness; Papilledema; Scotoma; Dyschromatopsia; Optic Nerve; Optic Disc; Retinal Ganglion Cells; Brazil; Apoptosis; Cell Death | |
| 38 |
 |
Apoptosis in LHON: An ROS Explanation | Alfredo A. Sadun, MD, PhD | A slide presentation describing apoptosis in LHON; includes several images of optic nerve and optic disk. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Optic Atrophy, Hereditary, Leber; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Apoptosis; Cell Death; ROS1 Protein, Human | |
| 39 |
 |
The Diagnostic Workup in Patients With Optic Neuropathies (Metodo diagnostico) | Alfredo A. Sadun, MD, PhD | Slideshow presentation with images of optic disc with edema and "Positive temporal artery biopsy". Presenting Symptom: Hyperopia; Metamorphopsia. Anatomy: Optic nerve; Macula Lutea; Optic disc. Disease/Diagnosis: Optic neuritis; Macular edema; Optic neuropathy, Ischemic. | Hyperopia; Metamorphopsia; Optic Nerve; Macula Lutea; Optic Disc; Optic Neuritis; Macular Edema; Optic Neuropathy, Ischemic | |
| 40 |
 |
Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindnes... | Optic Atrophy, Hereditary, Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 41 |
 |
Subclinical Visual Abnormalities in Carriers With 11778 LHON from a 300 Member Brazilian Pedigree | Alfredo A. Sadun, MD, PhD | Report of a multi-year international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presenting Symptom: Scotoma; Telangiectasis; Blindness. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Pathology: Slides showing LHON ... | Optic Atrophy, Hereditary, Leber; Optic Atrophy, Autosomal Dominant; Optic Nerve; Optic Disk; Myelin Sheath; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Blindness; Brazil | |
| 42 |
 |
Mitochondrial Optic Neuropathies (MON) | Alfredo A. Sadun, MD, PhD | Combination of two presentations on optic nerve diseases, covering the cases in Cuba and Brazil. Titles: Cuban epidemic of optic neuopathy: even zealots must eat, or, Conversations with Castro and Leber's hereditary optic neuropathy: a very large new pedigree in Brazil; includes several images of ... | Optic Nerve Diseases; Optic Atrophy, Hereditary, Leber; Blindness; Alcoholic Neuropathy; Cuba; Castro, Fidel; Folate; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death | |
| 43 |
 |
Beyond the Margulis Hypothesis: The Time Bomb Within Us | Alfredo A. Sadun, MD, PhD | Presented at Harvard, 2005; includes several images of optic disc with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Dyschromatopsia; Scotoma. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Dyschromatopsia; Scotoma | |
| 44 |
 |
How Strong is the Case for an Association Between PDE5 Inhibitors and NAION? | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve. Disease/Diagnosis: Optic Neuropathy, Ischemic; Toxic optic neuropathy. Presenting Symptom: Ischemia; Scotoma; Dyschromatopsia. | Optic Neuropathy, Ischemic; Toxic Optic Neuropathy; Ischemia; Scotoma; Dyschromatopsia; Optic Nerve; Phosphodiesterase 5 Inhibitor; Viagra | |
| 45 |
 |
Beyond the Margulis Hypothesis: The Time Bomb Within Us | Alfredo A. Sadun, MD, PhD | Presented at 36th Annual Doheny Days, 2005. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species | |
| 46 |
 |
Acute Retrobulbar Optical Neuropathy | Alfredo A. Sadun, MD, PhD | PPT covering acute retrobulbar optic neuropathy, including ischemic, inflammatory, anterior ischemic optic neuropathy (AION) and non-arteritic anterior ischemic optic neuropathy (NAION); includes brainscan images for optic neuritis and multiple sclerosis; optic disk with LHON and PION. Anatomy: Opt... | Optic Neuropathy, Ischemic; Giant Cell Arteritis; Edema; Multiple Sclerosis; Optic Atrophy, Hereditary, Leber; Ischemia; Hypotension; Edema; Optic Neuritis; Optic Nerve; Interferon-Beta-1a; Diseases of the Optic Nerve | |
| 47 |
 |
Leber's Hereditary Optic Neuropathy (LHON) in Brazil: Opportunities | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presented at Allergan, 2006. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Myelin sheath; Optic Disk. Disease/Diagnosis: Optic Atrophy, H... | Optic Atrophy, Hereditary, Leber; Optic Nerve; Optic Disk; Myelin Sheath; Brimonidine; Alphagan; Edema; Scotoma; Telangiectasis; Blindness; Brazil | |
| 48 |
 |
A Neuro-Ophthalmologist's View of RGC Apoptosis and Neuroprotection | Alfredo A. Sadun, MD, PhD | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma. Presen... | Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma | |
| 49 |
 |
Atypical Optic Neuropathies | Alfredo A. Sadun, MD, PhD | A discussion of atypical optic neuropathies. Anatomy: Optic nerve; Optic disc. Pathology: Slides showing LHON. Disease/Diagnosis: Optic neuropathy, Ischemic; Optic atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Optic neuritis; Eye hemorrhage; Retinal vasculitis; Dyschromatop... | Brazil; Cuba; Ethambutol; Optic Neuritis; Eye Hemorrhage; Retinal Vasculitis; Dyschromatopsia; Scotoma; Ataxia; Paresthesia; Hyporeflexia; Optic Nerve; Optic Disc; Optic Neuropathy, Ischemic; Optic Atrophy, Hereditary, Leber; Toxic Optic Neuropathy | |
| 50 |
 |
Extremely High Resolution Magnetic Resonance Imaging of the Human Optic Nerve Head | Alfredo A. Sadun, MD, PhD | MRI imagery of optic nerves demonstrates ability to identify cases of Leber's Hereditary Optic Neuropathy (LHON); includes MRI images of optic nerves. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Optic Nerve; Optic Atrophy, Hereditary, Leber; Magnetic Resonance Imaging |