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26 Raw deal: antagonism of Drosophila Jun N-terminal kinase signalingMany significant developmental and pathogenic processes require the Jun N-terminal kinase (JNK) signaling cascade. Using the powerful genetic model organism, Drosophila melanogaster, and specifically the morphogenetic event of embryonic dorsal closure, many components and regulators of the Drosophil...Pathogenic; Antagonists2005-05
27 Identification and characterization of the gene causing paroxysmal nonkinesigenic dyskinesiaParoxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal-dominant disorder that belongs to a group of hyperkinetic movement disorders called the paroxysmal dyskinesias. PNKD is characterized by spontaneous paroxysmal attacks of any combination of dystonia, chorea, athetosis, and ballism, which ar...Etiology; Genetics2005-05
28 Functional studies of the E74A protein during Drosophila metamorphosis.The onset of metamorphosis in Drosophila melanogaster is controlled by pulses of the steroid hormone 20-hydroxyecdysone. The striking tissue reorganization associated with this developmental event is attributed to complex and temporally coordinated programs of ecdysone-induced gene expression that a...Ecdysone; Molecular Biology; Genetics1995-06
29 Mitochondrial DNA evolution in the Nuu-chah-nulth population.The first 400 base pairs of the mitochondrial DNA (mtDNA) control region were sequenced from 118 stored serum samples that belonged to different social bands of the Nuu-chah-nulth population. The sequences were used to calculate lineage divergence within and between social bands. The divergence va...Nootka Indians; Human Populatoin Genetics1992-08
30 Analysis of T-cell receptor family prevalence in the chronically- activated T-cells of rheumatoid arthritis patientsRheumatoid arthritis (RA) is a chronic, progressive inflammatory disease which initially strikes the joints at the extremities, resulting in pain, swelling, stiffness, and loss of mobility, then later affects the larger joints. As the disease advances irreversible joint damage occurs, leading to def...Etiology; Phagocytic Cells1996-12
31 Genetic analysis of Drosophila steroid-triggered cell deathDevelopmental programmed cell death plays a central role in metazoan development. Among other key death inducing signals, small lipophilic hormones provide an indispensable cue for the precise temporal and spatial elimination of cells and tissues. In Drosophila, two sequential pulses of the steroid ...Genetics; Physiology2005-08
32 Role of PGRMC1 in intracellular sterol transport.Cholesterol is an essential component of mammalian cells. Cellular cholesterol levels are tightly regulated by various, well-characterized, homeostatic mechanisms that reside primarily in the endoplasmic reticulum. As the majority of cellular cholesterol resides in the plasma membrane and membrane d...Biological Transport; Physiology2008-12
33 Characterization of the NF1 gene and its gene product, neurofibromin.The neurofibromatosis 1 gene (NFl) spans approximately 350 kb of genomic DNA. To develop a comprehensive screen for NFl mutations, I constructed a genomic DNA contig that included the entire NFl cDNA sequence. Using these genomic clones, I identified all intron-exon boundaries of the NFl coding regi...cDNA; Genes1994-08
34 Transforming Growth Factor-Beta in Drosophila: characterization of punt and a screen for transcriptionally regulated targets.Transforming Growth Factor-Beta (TGF-Beta) signaling mediates a wide variety of biological activities including, growth and repair processes, tissue specification, modulation of endocrine activities, and apoptosis. TGF-Beta signaling components are highly conserved evolutionarily; thus our characte...Punt alleles; TGF-beta; Drosophila; Signal transduction; Genetics; Molecular Biology2001-08
35 T-box transcription factor interactions in the zebrafish mesoderm: regulation of gene expression and cell fate.T-box genes encode related transcription factors that regulate tissue specification and morphogenesis in vertebrates. Whereas individual T-box genes are commonly expressed across broad domains of precursor cells, phenotypic analyses of mutant embryos indicate that T-box genes often have regionally p...Genetics; Genetic Transmissibility2003-05
36 Hoxb1 coordinates neural circuitry in the vertebrate brainstemHox proteins are homeodomain containing, sequence specific, DNA-binding transcription factors that play a crucial role in the specification of antero-posterior identity in the animal. Loss of function analysis, through targeted gene inactivation, has provided valuable insight as to where individual ...Genetics; Proteins2004-12
37 Identification of retinoic acid-responsive genes in neuroblastoma cellsNeuroblastoma is the most common extracranial solid tumor in children. Despite increases in the intensity of treatment of this tumor over the past several decades, the long-term survival of patients with advanced neuroblastoma remains dismal. This lack of progress has sparked interest in the use of ...Therapy1999-12
38 Identification and Characterization of Genes Involved in Subcellular Lumen Formation in the Drosophilia Larval Tracheal SystemA common pattern in systems designed to transport liquids and gases, such as the vascular and respiratory systems, is the use of branched tubular structures to create a network that interconnects the entire body. The cellular cues required for generating these complex networks are not well understoo...2012-08
39 Transcriptional Regulation of Lipid Homeostasis in DrosophilaThe ability to sense metabolic status and coordinately regulate specific aspects of metabolism is central to human health and disease. The second chapter of this dissertation defines a role for the Drosophila nuclear receptor, DHR96, as a key regulator that coordinates triacylglycerol (TAG) and chol...2011-12
40 Computational Approaches to Biological Data With Applications in Image Analysis, Human Variant Prioritization, and MetagenomicsAdvances in technology have produced efficient and powerful scientific instruments for measuring biological phenomena. In particular, modern microscopes and nextgeneration sequencing machines produce data at such a rate that manual analysis is no longer practical or feasible for meaningful scientifi...2015-08
41 Enhancement of Vascular Stability Through ARF6 Deactivation Reduces Inflammatory PathologiesThe vasculature infuses nearly every tissue with oxygen and nutrients. It facilitates the transport of cells and chemical messages throughout the body and maintains proper fluid balance in the individual tissues. During angiogenesis and inflammation, vessels that compose the vasculature display enha...2014-08
42 The Roles of The Laminin Extracellular Matrix and Migratory Neural Crest Cells During Optic Cup MorphogenesisThe development of an organ involves establishment of its shape, which is often critical for proper function. Perhaps the most striking case where organ shape dictates function is in the vertebrate eye, where vision depends on many tissues taking on the correct shape, and becoming correctly oriented...Developmental biology; Cellular biology2018
43 Regulation of development and metabolic homeostasis by hepatocyte nuclear factor 4The maintenance of metabolic homeostasis presents a major challenge to animal biology. Dysregulation of this process is central to the etiology of diabetes and obesity, which have placed an ever-increasing burden on global human health. Nuclear receptors are a family of ligand-regulated transcriptio...Molecular biology; Genetics; Developmental biology2016
44 Metabolic Regulation at the Intersection of Genes and EnvironmentThe incidence of complex metabolic disease has risen to an alarming level in the last several decades. This elevated frequency has been accompanied by increased social and financial costs, with nearly $250 billion spent each year on diabetes alone. Despite this growing health crisis, only a small pe...2016-08
45 Endogenous retrovirus evolution in mammalian genomesEndogenous retroviruses (ERVs), derived from exogenous retroviruses (XRVs), comprise about 5 to 10 % of most mammalian genomes. We can study retroviral infection which originated millions years ago and understand long term evolution of infectious viruses by working on ERVs. At the same time, it has ...Genetics; Evolution and Development; Virology2017
46 Developing Computational Methods for Studying nonmodel Organism Genetics and Human Disease with Next-Generation Sequencing DataThe rapidly decreasing of costs of sequencing is revolutionizing genetics. Two applications of next-generation sequencing data are of particular importance in this regard. First, high-throughput sequencing now offers a fast and inexpensive means to investigate the genomes and genetics of nonmodel or...2012-12
47 Discovery and Analysis of Components of Nonsense Mediated Decay in DrosophilaNonsense mediated decay (NMD) is a cellular surveillance mechanism originally identified for its role in targeting mRNAs containing nonsense codons for rapid degradation. Nonsense codons, or premature termination codons (PTCs), are a common result of genomic mutation, alternative splicing, and progr...Genetics2013-05
48 Posttranscriptional Gene Regulation by the DMD 3'UTRDuch enne muscular dystrophy (DMD) and the milder Becker muscular dystrophy (BMD) are both caused by mutations in the DMD gene, which encodes the protein dystrophin. Its regulation is of therapeutic interest as even small changes in expression of functional dystrophin can significantly im pac...2014-08
49 A Seminal Fluid Serine Protease, TRY-5, Signals Caenorhabditis Elegans Sperm ActivationDuring mating males transfer not only sperm, but also protein and other substances in their seminal fluid. The functions of some seminal fluid components have been identified and these include aiding in sperm motility and protecting sperm from the harsh environment of the female reproductive tract. ...2012-08
50 COMP-1 Regulates Male and Hermaphrodite Bias of Sperm Selection in Caenorhabditis ElegansSperm competition is a pervasive mode of sexual selection across the phyla that have crucial implications in microevolutionary and macroevolutionary processes. Furthermore, females can bias the selection of sperm from one male over another in a process known as cryptic female choice. While sperm com...2015-05
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