The Alfredo A. Sadun Neuro-Ophthalmology Collection: A Professor of Ophthalmology and Neurological Surgery at the USC Keck School of Medicine, Dr. Sadun with a team of researchers at the Doheny Eye Institute pioneered research in optic nerve dysfunction in patients with Alzheimer's disease. Contains his "100 best lectures." Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor Ophthalmology & Neurological Surgery, Doheny Eye Institute, Keck School of Medicine at USC.
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| Title | Creator | Description | Subject | Imaging | ||
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The Neuro-Ophthalmic Manifestations of Diabetes | Alfredo A. Sadun, MD, PhD | Anatomy: Orbit; Optic nerve. Disease/Diagnosis: Diabetes; Mucormycosis; Acidosis; Hypoplasia of the optic nerve; Diabetes mellitus; Diabetic optic papillopathy; Optic neuropathy, Ischemic; Diabetic optic atrophy; Ophthalmoplegia; Arteritis; Diabetic ketoacidosis; Orbital cellulitis. Treatment: Debri... | Diabetes; Mucormycosis; Acidosis; Hypoplasia of the Optic Nerve; Diabetes Mellitus; Diabetic Optic Papillopathy; Optic Neuropathy, Ischemic; Diabetic Optic Atrophy; Ophthalmoplegia; Arteritis; Diabetic Ketoacidosis; Orbital Cellulitis; Hyphae; Orbit; Optic Nerve; Debridement | |
| 2 |
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AIDS: Neuro-Ophthalmologic Manifestations | Alfredo A. Sadun, MD, PhD | Discusses various neuro-opthalmological complications to which AIDS patients are prone, and results of experimental testing on rabbits using Pentoxifylline. Anatomy: Optic nerve; Axons; Optic disk; Astrocytes; Macrophages. Pathology: Slides showing astrocytes, macrophages, cytokine staining. Disease... | Optic Nerve; Axons; Optic Disk; Astrocytes; Macrophages; Infarction; Pneumocystis Carinii; Acquired Immunodeficiency Syndrome; Cytomegalovirus Retinitis; Retinal Necrosis Syndrome, Acute; Cryptococcus; Meningitis; Leukoencephalopathy, Progressive Multifocal; Papilledema; AIDS Dementia Complex; Cellu... | |
| 3 |
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Visual Fields | Alfredo A. Sadun, MD, PhD | Slideshow presentation with images of bow-tie atrophy due to an optic disc tract lesion. Anatomy: Optic chiasm; Optic nerve; Optic disk. Disease/Diagnosis: Pituitary adenoma; Bitemporal hemianopia; Optic nerve atrophy. | Visual Fields; Amsler Chart; Optic Chiasm; Optic Nerve; Optic Disk; Pituitary Adenoma; Bitemporal Hemianopia; Optic Nerve Atrophy | |
| 4 |
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Optical Coherence Tomography (OCT) Applications in the Eye | Alfredo A. Sadun, MD, PhD | Optical Coherence Tomography is a technique for non-invasive cross-sectional imaging of ocular tissues. This PowerPoint covers an overview of the technique with excellent diagrams and images. Anatomy: Retina; Anterior eye segment; Cornea; Macula Lutea; Vitreous body; Optic nerve; Retinal ganglion ce... | Tomography, Optical Coherence; Retina; Anterior Eye Segment; Cornea; Macula Lutea; Vitreous Body; Optic Nerve; Retinal Ganglion Cells; Retinal Diseases; Glaucoma; Macular Edema; Retinal Edema; NFLA Optical Coherence Tomography | |
| 5 |
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Prognosis for Vision in Idiopathic Intracranial Hypertension (IIH) | Alfredo A. Sadun, MD, PhD | Treatment options for Pseudotumor cerebri and Papilledema; includes images of optic disc with edema. Presenting Symptom: Scotoma. Anatomy: Optic disc; Optic nerve. Pathology: Microscopic view of papilledema. Disease/Diagnosis: Pseudotumor cerebri; Papilledema. Treatment: Acetazolamide; Ventriculoper... | Optic Nerve; Optic Disc; Pseudotumor Cerebri; Papilledema; Scotoma; Acetazolamide; Ventriculoperitoneal Shunt; Lumbo-Peritoneal CSF Shunt; Decompression of Optic Nerve; Raised Intracranial Pressure | |
| 6 |
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Viagra and Vision Loss: Does Sex Make You Blind? | Alfredo A. Sadun, MD, PhD | Presenting symptom: Hypotension. Anatomy: Optic nerve; Optic disc; Cyclic Nucleotide Phosphodiesterases, Type 5. Disease/Diagnosis: Optic Neuropathy, Ischemic; Toxic optic neuropathy. | Sildenafil; Vardenafil; Tadalafil; Viagra; Levitra; Cialis; Optic Neuropathy, Ischemic; Toxic Optic Neuropathy; Optic Nerve; Optic Disc; Cyclic Nucleotide Phosphodiesterases, Type 5; Hypotension | |
| 7 |
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Optic Nerve Tumors: Diagnosis and Therapy | Alfredo A. Sadun, MD, PhD | Powerppoint lecture covers a patient case, differential diagnosis, and optic nerve anatomy. Also includes examination information, fundus images and visual field defects. Presenting Symptom: Proptosis; Hemianopsia; Scotoma. Anatomy: Optic nerve; Structure of pituitary fossa; Optic nerve sheath. Dise... | Optic Nerve; Structure of Pituitary Fossa; Optic Nerve Sheath; Proptosis; Hemianopsia; Scotoma; Optic Nerve Neoplasms; Meningioma; Optic Nerve Glioma; Chiasmal Visual Field Defects | |
| 8 |
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Visual Cortex and Weird Phenomena (Anton's to Riddoch's) | Alfredo A. Sadun, MD, PhD | Presenting Symptom: Alexia, Pure; Agraphia; Prosopagnosia; Palinopsia; Geschwind's Syndrome; Apraxia. Anatomy: Visual cortex; Optic nerve. Disease/Diagnosis: Aphasia; Hallucinations, Visual; Anton's Syndrome; Visual Agnosia; Blindness, Cortical; Cortical paralysis of fixation syndrome; Alzheimer's S... | Alexia, Pure; Agraphia; Prosopagnosia; Palinopsia; Geschwind's Syndrome; Apraxia; Aphasia; Hallucinations, Visual; Anton's Syndrome; Visual Agnosia; Blindness, Cortical; Cortical Paralysis of Fixation Syndrome; Alzheimer's Syndrome; Visual Cortex; Optic Nerve; Higher Cortical Dysfunction; Specializ... | |
| 9 |
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Anatomy and Physiology of the Optic Nerve | Alfredo A. Sadun, MD, PhD | Lecture covering the anatomy and physiology of the optic nerve. Covers the retina and anterior visual pathways. Several slides show microscopic images of optic nerve damage. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma; Anatomy of the Optic Nerve; AVP Optic Nerve | |
| 10 |
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Toxic Optic Neuropathies: Mitochondria and the RGC | Alfredo A. Sadun, MD, PhD | Discussion of various forms of mitrochondrial optic neuropathies and how to distinguish from toxic optic neuropathies, with examples from Cuba and Brazil; includes images of optic disc showing LHON. Presenting Symptom: Blindness; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia. Anatomy: Optic ne... | Optic Nerve; Optic Disc; Retinal Ganglion Cells; Reactive Oxygen Species; Blindness; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Optic Atrophy, Autosomal Dominant; Optic Atrophy, Hereditary, Leber; Toxic Optic Neuropathy; Alcoholic Neuropathy; Brazil; Cuba; Linezolid; Ethambutol; Tomography... | |
| 11 |
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Posterior Ischemic Optic Neuropathy | Alfredo A. Sadun, MD, PhD | Discusses opthalmic complications of surgery, with example of shock-induced Posterior Ischemic Optic Neuropathy following a hysterectomy. Presenting Symptom: Ischemia; Hypotension. Anatomy: Optic nerve. Disease/Diagnosis: Optic neuropathy, Ischemic; Hematoma; Edema. | Optic Neuropathy, Ischemic; Hematoma; Edema; Ischemia; Hypotension; Optic Nerve; Posterior Ischemic Optic Neuropathy | |
| 12 |
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Cushing and Ophthalmology | Alfredo A. Sadun, MD, PhD | From a lecture at Yale in 2006, reviewing the life of Harvey Cushing, the founder of neurosurgery. Anatomy: Optic chiasm; Optic nerve. Disease/Diagnosis: Pituitary adenoma; Papilledema; X-linked hydrocephalus syndrome; Optic nerve glioma; Graves ophthalmopathy; Mucocele; Pituitary apoplexy; Optic ne... | Cushing, Harvey, 1869-1939; Neurosurgery; Optic Chiasm; Optic Nerve; Proptosis; Diplopia; Ptosis; Hemianopsia; Pituitary Adenoma; Papilledema; X-linked Hydrocephalus Syndrome; Optic Nerve Glioma; Graves Ophthalmopathy; Mucocele; Pituitary Apoplexy; Optic Nerve Atrophy; Neurosurgery; Decompression, S... | |
| 13 |
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How Mitochondria Orchestrate the Death of RGCs : From Brazil to Tuebingen to Rochester 2007 | Alfredo A. Sadun, MD, PhD | Slides showing LHON and Kjer's optic atrophy and images of optic disk with LHON. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Blindness. | Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Apoptosis; Cell Death; Dyschromatopsia; Blindness; Optic Atrophy; Hereditary; Leber; Leber's Optic Neuropathy | |
| 14 |
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Pupils and the Neuro-Ophthalmic Manifestations of Diabetes | Alfredo A. Sadun, MD, PhD | Presentation given in Italy on diagnosing neuro-opthalmic complications of diabetes with several views of the optic disc. Presenting symptom: Diplopia; Anisocoria; Ptosis; Horner syndrome; Adie syndrome. Anatomy: Pupil; Optic disc; Optic nerve. Disease/Diagnosis: Diabetes; Mucormycosis; Acidosis; Hy... | Pupil; Optic Disc; Optic Nerve; Diplopia; Anisocoria; Ptosis; Horner Syndrome; Adie Syndrome; Diabetes; Mucormycosis; Acidosis; Hypoplasia of the Optic Nerve; Diabetes Mellitus; Diabetic Optic Papillopathy; Optic Neuropathy, Ischemic; Diabetic Optic Atrophy; Ophthalmoplegia; Diabetic Ketoacidosis; D... | |
| 15 |
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Anatomy and Physiology of Vision: The Visual Pathways | Alfredo A. Sadun, MD, PhD | Introduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn... | Optic Nerve; Optic Disc; Retina; Retinal Ganglion Cells; Optic Chiasm; Visual Cortex; Pituitary Adenoma; Optic Atrophy; Anatomy of Visual Pathways; Afferent Visual Pathways | |
| 16 |
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Apoptosis of Retinal Ganglion Cells | Alfredo A. Sadun, MD, PhD | Presented at a conference on neuroprotection at Sedona, Arizona, 2002; includes several microscopic images demonstrating cell death. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma | |
| 17 |
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Compressive Optic Neuropathies Potpourri | Alfredo A. Sadun, MD, PhD | An overview of compressive optic neuropathies, including symptoms, varieties, testing, and treatments; slide presentation includes several neuroimaging scans. Anatomy: Optic nerve. Disease/Diagnosis: Compression of optic nerve. Treatment: Mifepristone | Optic Nerve; Compression of Optic Nerve; Mifepristone | |
| 18 |
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Distinguishing an Optic Neuropathy from a Maculopathy | Alfredo A. Sadun, MD, PhD | PPT describing a case of optic neuropathy. Covers signs and symptoms, and various laboratory tests. Describes 10 signes of disc edema. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; Afferent pupillar... | Optic Nerve Diseases; Retinal Lesion; Macular Lesion; Disorder of the Optic Nerve; Afferent Pupillary Defect; Edema; Optic Nerve; Retina; Retinal Macula; Scotoma; Optic Neuritis; Hyperopia; Metamorphopsia; Diseases of the Optic Nerve | |
| 19 |
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Distinguishing Optic Nerve vs. Retinal Lesions | Alfredo A. Sadun, MD, PhD | PPT describing methods of distinguishing optic nerve verses retinal lesions. Describes a pateint case. Discussed signs, symtpoms and diagnostic tests. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; A... | Optic Nerve Diseases; Retinal Lesion; Disorder of the Optic Nerve; Macular Lesion; Retinal Macula; Afferent Pupillary Defect; Scotoma; Optic Neuritis; Hyperopia; Metamorphopsia; Optic Nerve; Retina; Diseases of the Optic Nerve | |
| 20 |
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Engineering the Visual System | Alfredo A. Sadun, MD, PhD | Physiological basis of vision, covering perimetry, retinal ganglion cell types, and retinal pathways. Anatomy: Optic nerve; Retina. | Vision; Color Perception; Optic Nerve; Retina; Afferent Visual Pathways | |
| 21 |
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Field Investigation of a Giant Pedigree of LHON in Rural Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness, | Optic Atrophy; Hereditary; Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 22 |
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Leber's Hereditary Optic Neuropathy (LHON): New Rules of Engagement | Alfredo A. Sadun, MD, PhD | Slide presentation with several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Optic Atrophy; Hereditary; Leber; Apoptosis; Cell Death; Blindness; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species | |
| 23 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree From Brazil | Alfredo A. Sadun, MD, PhD | Four slides showing optic disc with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Optic Atrophy; Hereditary; Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 24 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON, Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Optic Atrophy; Hereditary; Leber; Blindness; Scotoma; Dyschromatopsia; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death | |
| 25 |
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Management Approach to Isolated Ocular Motor Nerve Palsies | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve; Oculomotor nerve; Trochlear nerve; Abducens nerve; Pupil. Disease/Diagnosis: Oculomotor nerve diseases; Trochlear nerve diseases; Oculomotor nerve paralysis; Fourth cranial nerve palsy; Abducens nerve diseases; Gradenigo's syndrome; Ophthalmoplegia; Temporal Arteritis; Nerve co... | Diplopia; Hypertropia; Optic Nerve; Oculomotor Nerve; Trochlear Nerve; Pupil; Oculomotor Nerve Diseases; Trochlear Nerve Diseases; Abducens Nerve; Abducens Nerve Diseases; Gradenigo's Syndrome; Ophthalmoplegia; Temporal Arteritis; Nerve Compression Syndromes |