The Alfredo A. Sadun Neuro-Ophthalmology Collection: A Professor of Ophthalmology and Neurological Surgery at the USC Keck School of Medicine, Dr. Sadun with a team of researchers at the Doheny Eye Institute pioneered research in optic nerve dysfunction in patients with Alzheimer's disease. Contains his "100 best lectures." Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor Ophthalmology & Neurological Surgery, Doheny Eye Institute, Keck School of Medicine at USC.
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| Title | Creator | Description | Subject | Imaging | ||
|---|---|---|---|---|---|---|
| 26 |
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Posterior Ischemic Optic Neuropathy | Alfredo A. Sadun, MD, PhD | Discusses opthalmic complications of surgery, with example of shock-induced Posterior Ischemic Optic Neuropathy following a hysterectomy. Presenting Symptom: Ischemia; Hypotension. Anatomy: Optic nerve. Disease/Diagnosis: Optic neuropathy, Ischemic; Hematoma; Edema. | Optic Neuropathy, Ischemic; Hematoma; Edema; Ischemia; Hypotension; Optic Nerve; Posterior Ischemic Optic Neuropathy | |
| 27 |
 |
The Neuro-Ophthalmic Manifestations of Diabetes | Alfredo A. Sadun, MD, PhD | Anatomy: Orbit; Optic nerve. Disease/Diagnosis: Diabetes; Mucormycosis; Acidosis; Hypoplasia of the optic nerve; Diabetes mellitus; Diabetic optic papillopathy; Optic neuropathy, Ischemic; Diabetic optic atrophy; Ophthalmoplegia; Arteritis; Diabetic ketoacidosis; Orbital cellulitis. Treatment: Debri... | Diabetes; Mucormycosis; Acidosis; Hypoplasia of the Optic Nerve; Diabetes Mellitus; Diabetic Optic Papillopathy; Optic Neuropathy, Ischemic; Diabetic Optic Atrophy; Ophthalmoplegia; Arteritis; Diabetic Ketoacidosis; Orbital Cellulitis; Hyphae; Orbit; Optic Nerve; Debridement | |
| 28 |
 |
Office Techniques for Detecting Optic Nerve Disease | Alfredo A. Sadun, MD, PhD | Demonstration of brightness sense testing and of computer-generated graphics for Amsler grid testing. Presenting Symptom: Scotoma; Metamorphopsia. Anatomy: Optic nerve; Retina; Macula lutea. Disease/Diagnosis: Glaucoma; Optic neuritis; Macular degeneration. | Color Vision; Glaucoma; Macular Degeneration; Optic Neuritis; Scotoma; Metamorphopsia; Optic Nerve; Retina; Macula Lutea | |
| 29 |
 |
The Diagnostic Workup in Patients With Optic Neuropathies (Metodo diagnostico) | Alfredo A. Sadun, MD, PhD | Slideshow presentation with images of optic disc with edema and "Positive temporal artery biopsy". Presenting Symptom: Hyperopia; Metamorphopsia. Anatomy: Optic nerve; Macula Lutea; Optic disc. Disease/Diagnosis: Optic neuritis; Macular edema; Optic neuropathy, Ischemic. | Hyperopia; Metamorphopsia; Optic Nerve; Macula Lutea; Optic Disc; Optic Neuritis; Macular Edema; Optic Neuropathy, Ischemic | |
| 30 |
 |
How Strong is the Case for an Association Between PDE5 Inhibitors and NAION? | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve. Disease/Diagnosis: Optic Neuropathy, Ischemic; Toxic optic neuropathy. Presenting Symptom: Ischemia; Scotoma; Dyschromatopsia. | Optic Neuropathy, Ischemic; Toxic Optic Neuropathy; Ischemia; Scotoma; Dyschromatopsia; Optic Nerve; Phosphodiesterase 5 Inhibitor; Viagra | |
| 31 |
 |
Optic Nerve Regeneration | Alfredo A. Sadun, MD, PhD | A slide presentation with three sets of 3 views increasing magnification. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic neuropathy, Ischemic; Retrograde degeneration; Necrosis. Treatment: Cerestat; Aptiganel; Memantine; Riluzole. | Nerve Regeneration; Optic Nerve; Retina; Retrograde Degeneration; Necrosis; Apoptosis; Cell Death; Cerestat; Aptiganel; Memantine; Riluzole | |
| 32 |
 |
Pentoxifylline Suppression of TNF-Alpha Mediated Axonal Degeneration in the Rabbit Optic Nerve | Alfredo A. Sadun, MD, PhD | Presenting Symptom: Dyschromatopsia. Anatomy: Optic nerve. Disease/Diagnosis: Acquired Immunodeficiency Syndrome; Demyelinating autoimmune diseases, CNS. Treatment: Pentoxifylline. | Pentoxifylline; Optic Nerve; Acquired Immunodeficiency Syndrome; Demyelinating Autoimmune Diseases, CNS; Dyschromatopsia; Tumor Necrosis Factor-Alpha | |
| 33 |
 |
Beyond the Margulis Hypothesis: The Time Bomb Within Us | Alfredo A. Sadun, MD, PhD | Presented at 36th Annual Doheny Days, 2005. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species | |
| 34 |
 |
Pupils and Fields: The Importance of Assessing the Optic Nerve | Alfredo A. Sadun, MD, PhD | Presenting Symptom: Anisocoria; Adie syndrome; Scotoma; Afferent pupillary defect; Horner Syndrome; Edema; Papilledema; Optic nerve; Pupil; Optic disc. Anatomy: Optic nerve; Pupil; Optic disc. Disease/Diagnosis: Afferent pupillary defect; Horner Syndrome; Edema; Papilledema. | Anisocoria; Adie Syndrome; Scotoma; Afferent Pupillary Defect; Horner Syndrome; Edema; Papilledema; Optic Nerve; Pupil; Optic Disc | |
| 35 |
 |
Pupils and the Neuro-Ophthalmic Manifestations of Diabetes | Alfredo A. Sadun, MD, PhD | Presentation given in Italy on diagnosing neuro-opthalmic complications of diabetes with several views of the optic disc. Presenting symptom: Diplopia; Anisocoria; Ptosis; Horner syndrome; Adie syndrome. Anatomy: Pupil; Optic disc; Optic nerve. Disease/Diagnosis: Diabetes; Mucormycosis; Acidosis; Hy... | Pupil; Optic Disc; Optic Nerve; Diplopia; Anisocoria; Ptosis; Horner Syndrome; Adie Syndrome; Diabetes; Mucormycosis; Acidosis; Hypoplasia of the Optic Nerve; Diabetes Mellitus; Diabetic Optic Papillopathy; Optic Neuropathy, Ischemic; Diabetic Optic Atrophy; Ophthalmoplegia; Diabetic Ketoacidosis; D... | |
| 36 |
 |
Leber's Hereditary Optic Neuropathy (LHON) in Brazil: Opportunities | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presented at Allergan, 2006. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Myelin sheath; Optic Disk. Disease/Diagnosis: Optic Atrophy, H... | Optic Atrophy, Hereditary, Leber; Optic Nerve; Optic Disk; Myelin Sheath; Brimonidine; Alphagan; Edema; Scotoma; Telangiectasis; Blindness; Brazil | |
| 37 |
 |
Jonathan D. Wirtschafter, MD, FACS, Frank E. Burch Professor of Ophthalmology | Alfredo A. Sadun, MD, PhD | Overview of the life of Jonathan D. Wirtschafter on the occasion of the first annual Wirtschafter Lectureship, in August of 2003. Sadun gave the lecture, recapping an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images o... | Optic Atrophy, Hereditary, Leber; Blindness; Scotoma; Dyschromatopsia; Brazil; Optic Nerve; Optic Disk; Apoptosis; Cell Death; Wirtschafer, Jonathan D. | |
| 38 |
 |
Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON, Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Optic Atrophy; Hereditary; Leber; Blindness; Scotoma; Dyschromatopsia; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death | |
| 39 |
 |
Beyond the Margulis Hypothesis: The Time Bomb Within Us | Alfredo A. Sadun, MD, PhD | Presented at Harvard, 2005; includes several images of optic disc with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Dyschromatopsia; Scotoma. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Dyschromatopsia; Scotoma | |
| 40 |
 |
Leber's Hereditary Optic Neuropathy (LHON): New Rules of Engagement | Alfredo A. Sadun, MD, PhD | Slide presentation with several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Optic Atrophy; Hereditary; Leber; Apoptosis; Cell Death; Blindness; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species | |
| 41 |
 |
Leber's Hereditary Optic Neuropathy: New Lessons From a Giant Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Optic Atrophy, Hereditary, Leber; Blindness; Papilledema; Scotoma; Dyschromatopsia; Optic Nerve; Optic Disc; Retinal Ganglion Cells; Brazil; Apoptosis; Cell Death | |
| 42 |
 |
The Diagnostic Workup in Patients With Optic Neuropathies | Alfredo A. Sadun, MD, PhD | Slideshow presentation with images of optic disc with edema and optic atrophy. Presenting Symptom: Telangiectasis; Dyschromatopsia; Scotoma. Anatomy: Optic nerve; Optic disc; Phosphopyruvate Hydratase; Enolase. Disease/Diagnosis: Optic neuritis; Macular edema; Optic neuropathy, Ischemic; Optic atrop... | Telangiectasis; Dyschromatopsia; Scotoma; Optic Nerve; Optic Disc; Phosphopyruvate Hydratase; Enolase; Optic Neuritis; Macular Edema; Optic Neuropathy, Ischemic; Optic Atrophy, Hereditary | |
| 43 |
 |
Apoptosis in LHON: An ROS Explanation | Alfredo A. Sadun, MD, PhD | A slide presentation describing apoptosis in LHON; includes several images of optic nerve and optic disk. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Optic Atrophy, Hereditary, Leber; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Apoptosis; Cell Death; ROS1 Protein, Human | |
| 44 |
 |
Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Scotoma; Dyschromatopsia. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Toxic Optic Neuropathy; Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species; Amiodarone; Scotoma; Dyschromatopsia | |
| 45 |
 |
Neuroprotection = Apoptosis of Retinal Ganglion Cells | Alfredo A. Sadun, MD, PhD | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Presenting Symptom: Blindness; Ischemia; Retinal detachment. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunod... | Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy; Hereditary; Leber; Acquired Immunodeficiency Syndrome | |
| 46 |
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Viagra and Vision Loss: Does Sex Make You Blind? | Alfredo A. Sadun, MD, PhD | At a formal debate during a meeting in Canada in Sept. 2006, Sadun was assigned the role of arguing the case FOR a connection between taking phosphodiesterase 5 (PDE5) inhibitors and developing anterior ischemic optic neuropathy. Presenting Symptom: Hypotension. Anatomy: Optic nerve; Optic disc; Cyc... | Sildenafil; Vardenafil; Tadalafil; Viagra; Levitra; Cialis; Optic Neuropathy, Ischemic; Toxic Optic Neuropathy; Optic Nerve; Optic Disc; Cyclic Nucleotide Phosphodiesterases, Type 5; Hypotension | |
| 47 |
 |
Viagra and Vision Loss: Does Sex Make You Blind? | Alfredo A. Sadun, MD, PhD | Presenting symptom: Hypotension. Anatomy: Optic nerve; Optic disc; Cyclic Nucleotide Phosphodiesterases, Type 5. Disease/Diagnosis: Optic Neuropathy, Ischemic; Toxic optic neuropathy. | Sildenafil; Vardenafil; Tadalafil; Viagra; Levitra; Cialis; Optic Neuropathy, Ischemic; Toxic Optic Neuropathy; Optic Nerve; Optic Disc; Cyclic Nucleotide Phosphodiesterases, Type 5; Hypotension | |
| 48 |
 |
A Neuro-Ophthalmologist's View of RGC Apoptosis and Neuroprotection | Alfredo A. Sadun, MD, PhD | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma. Presen... | Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma | |
| 49 |
 |
Anatomy and Physiology of Vision: The Visual Pathways | Alfredo A. Sadun, MD, PhD | Introduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn... | Optic Nerve; Optic Disc; Retina; Retinal Ganglion Cells; Optic Chiasm; Visual Cortex; Pituitary Adenoma; Optic Atrophy; Anatomy of Visual Pathways; Afferent Visual Pathways | |
| 50 |
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How Mitochondria Orchestrate the Death of RGCs : From Brazil to Tuebingen to Rochester 2007 | Alfredo A. Sadun, MD, PhD | Slides showing LHON and Kjer's optic atrophy and images of optic disk with LHON. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Blindness. | Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Apoptosis; Cell Death; Dyschromatopsia; Blindness; Optic Atrophy; Hereditary; Leber; Leber's Optic Neuropathy |