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TitleDescriptionSubjectCollection
1 : Lymph node (rat)Electron microscopy. A low magnification of a part of the medulla showing medullary cords surrounded by labyrinthine medullary sinus (*). In this picture the medullar cord runs from left bottom corner to right top corner, and is lined by flat reticular cell types. Within the cord one finds a star-sh...medulla; electron microscopy; sinusoidPoja Histology Collection - Lymphatic Tissues and Organs Subset
2 Calcified bacterial plaque in palatine tonsil ('gut-associated lymphatic tissue' or GALT) (human)Stain: Azan. A tonsillar crypt lined by squamous epithelium (2) that is infiltrated with lymphocytes (1). It is a normal finding that within the crypts free cells, plugs of lymphocytes (1) and calcified epithelial debris as well as colonies of oral commensally bacteria are present. (3) shows a calc...bacterial plaquePoja Histology Collection - Lymphatic Tissues and Organs Subset
3 Cortex of lymph node (human)Stain: Azan. The cortex of the lymph node comprises the (secondary) follicles with germinal centres (1) and corona or mantle zone (2), all filled with B lymphocytes. The paracortical area (3) below the follicles largely comprises T cells. Afferent lymph vessels enter via the capsule (6) into the m...cortex; paracortexPoja Histology Collection - Lymphatic Tissues and Organs Subset
4 Scheme of secondary lymphatic nodule in spleen (human)A. histological impression of a follicle or nodule B. outline of impression 1. pulpa artery; 2. central artery ; 3. lymphatic sheath; 4. lymphatic nodule; 5. thymus-dependent area (periarteriolar lymphatic sheath or PALS), composed of Th subset lymphocytes; 6. mantle zone with mainly nave B l...white pulp; marginal zone; antigen presenting cell (APC)Poja Histology Collection - Lymphatic Tissues and Organs Subset
5 Splenic sheathed capillaries (human)Stain: Azan. The blood flow in the spleen goes from splenic artery to trabecular artery to central or follicular artery (with a periarteriolar lymphatic sheath or PALS), and upon leaving the follicle the blood flows through penicillar arterioles and sheathed capillaries and terminal arterial capilla...penicillar arterioles; red pulp; sheathed capillariesPoja Histology Collection - Lymphatic Tissues and Organs Subset
6 Thymus medulla (rat, neonate)Electron microscopy. An interdigitating cell in the thymic corticomedullary region shows a large electron-light cytoplasm with a complex branching (7) at the periphery. The nucleus is sectioned twice (1). There is abundance of organelles as well as of quite uniform electron-dense lysosomal structure...medullar epithelioreticular cell; interdigitating cell; corticomedullar region; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
7 Scheme of the thymus medulla (human)A-B: medullar epithelioreticular cells; C-D-E: development stages of thymic corpuscles (or Hassall bodies) (1): branching (-->) epithelioreticular cells in the medulla forming a meshwork (cytoreticulum) that normally is populated by thymocytes; (2): specialized epithelioreticular cells (2) often...thymic corpuscle; Hassall ; epithelioreticular cells ; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
8 Appendix ('gut-associated lymphatic tissue' or GALT) (human)Stain: Azan. Survey of vermiform appendix (see also Digestive System: Appendix) A large amount of non-encapsulated diffuse lymphatic tissue or mucosa-associated lymphatic tissue (MALT) is located in the subepithelial lamina propria/submucosa of the appendix and called gut-associated lymphatic tissue...GALT; follicle; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
9 Survey of part of splenic lymphatic nodule (rat)Electron microscopy. (1) shows an arteriolar branch of a central artery, and cross-sections of capillary branches (1a). Within the periarteriolar lymphatic sheath (PALS) mostly T lymphocytes (5) are present between concentric arranged reticular cells (2). Cells with larger lighter stained nuclei rep...central artery ; electron microscopy; PALS; Antigen presenting cells (APC)Poja Histology Collection - Lymphatic Tissues and Organs Subset
10 Cystic corpuscle in thymus (mouse, young adult)Electron microscopy. This cystic corpuscle is lined by specialized epithelioreticular cells and exhibits a lumen (1) which is filled with long microvilli however, curiously derived from a flattened epithelial cell (2, nucleus). The cell contains few electron-dense keratohyalin granules (3). (-->) po...epithelioreticular cells; thymic corpuscle; thymic cyst; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
11 Thymus cortex (mouse, young adult)Electron microscopy. (1) A well developed desmosome (1) of an epithelioreticular cells type II (TEC2). Apart from few free ribosomes, glycogen granules (2) are present in the electron-light cytoplasm. (3) part of an electron-grey thymocyte with many ribosomes.epithelioreticular cell type II ; desmosome; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
12 Dendritic cells in spleen (mouse)Electron microscopy. The interdigitations (*) of the left dendritic cells (antigen-presenting cell or APC) (1 and 2a) are clearly shown. The right (2b) is a neighbour dendritic cell sectioned at the level of the Golgi area. (3) lymphocyte and (4) reticular cell.electron microscopy; dendritic cellPoja Histology Collection - Lymphatic Tissues and Organs Subset
13 Scheme of the spleen (human)Spleen: A. general diagram; B. adult; C. senium 1. capsule of dense irregular connective tissue with few elastic and smooth muscle fibers (it varies with the species); 2. trabecula (septum); 3. trabecular artery derived from the splenic artery; 4. trabecular vein; 5. when the pulpa artery ...white pulp; red pulpPoja Histology Collection - Lymphatic Tissues and Organs Subset
14 White pulp of spleen (mouse)Stain: Hematoxylin & eosin in A and alkaline phosphatase in B (with substrate Naphtol Fast Blue RR). The general structure of the white pulp of the spleen and its specific microenvironment for T and B cells is well illustrated using alkaline phosphatase that strongly stains the capillaries around th...alkaline phosphatase; PALS; T lymphocytes; white pulpPoja Histology Collection - Lymphatic Tissues and Organs Subset
15 The effect of cyclophosphamide treatment on the B and T cells in spleen (rat)Stain: Immunoperoxidase staining using diaminobenzidin (DAB)/ hematoxylin counterstained on frozen section with antibodies to B cells (Mark 1), CD3 and CD8 T cells. (A): B cells in the follicles, germinal centres (2) and corona are stained positive brown, while the PALS area (1) is negative (blue)...CD3 lymphocytes; CD8 lymphocytes; B lymphocytes; cyclophosphamidePoja Histology Collection - Lymphatic Tissues and Organs Subset
16 Age involution of thymus (human, postpuberal)Stain: Azan. The size of the thymus is age-dependent, and undergoes a continuous process of involution, starting at postpuberal age. Due to depletion and reduced production of cortical thymocytes, as well as a gradual atrophy of the epithelial cells, the clear distinction between medulla (1) and cor...thymus age; adipose cells; thymus involution; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
17 Immunohistochemical identification of splenic B cells (rat)Stain: Immunofluorescence of FITC-labeled anti-Mark-1 antibody against rat B cells, carried out on spleen cells after fixation (A, B) or non-fixated spleen cells (C). (A) shows (young) plasma cells producing antibodies. (B) a green-stained B cell. The surrounding negative cells are likely T cells....immunofluorescence; B lymphocyte; cappingPoja Histology Collection - Lymphatic Tissues and Organs Subset
18 Thymus cortex (mouse, young adult)Electron microscopy. Surrounded by thymocytes (2) a cortical macrophage (starry-sky macrophage) is seen and shows an electron-light nucleus (N) and a distinct nucleolus. The cell has engulfed two apoptotic thymocytes (1). The cytoplasm also contains small electron-dense lysosomes and myelin figures ...cortical macrophage; epithelioreticular cell type II ; apoptotic thymocyte; lymphoid tissuePoja Histology Collection - Lymphatic Tissues and Organs Subset
19 Survey of splenic trabecular artery (human)Stain: Azan. The splenic artery (or lienal artery) is the blood vessel that provides oxygenated blood to the spleen. Branches of the splenic artery divide into trabecular arteries (1) which enter the white pulp as central arteries (4) that is surrounded with lymphocytes (5,periarteriolar lymphatic s...trabecular artery; PALS; sinusoidPoja Histology Collection - Lymphatic Tissues and Organs Subset
20 Immunohistochemistry of B cells in splenic white pulp (rat)Stain: Immunohistochemistry of Vector red for Mark-1-antibody-stained B cells. (1) indicates the PALS area populated with unstained T cells located around the central artery of the white pulp. (2) indicates the positively red stained B cells in the germinal centre of the follicle. (3) the B-cells i...marginal zone; immunohistochemistry; folliclePoja Histology Collection - Lymphatic Tissues and Organs Subset
21 Penicillar arterioles in spleen (human)Stain: Azan. The central or follicular artery in the follicle of the spleen splits into many arterioles. These arterioles spread as so-called penicillar arterioles (1) shown here. They are still surrounded by a very thin perilymphatic sheath (PALS) that disappears as the arteries in a brush-like pat...penicillar arterioles; red pulpPoja Histology Collection - Lymphatic Tissues and Organs Subset
22 Localization of heparan sulfate (HS) in spleen (rat)Stain: Immunofluorescence of Alexa 594 red labeled single chain antibody 3C3 for heparan sulfate (HS). The antibody stains HS epitopes of the meshwork of reticulum cells and the basal membrane of blood vessels. (1) central arteries in the T cell area of the PALS (2). The B cell area in the follic...white pulp; heparan sulfate; PALSPoja Histology Collection - Lymphatic Tissues and Organs Subset
23 Thymic nurse cell (TNC) (mouse)Electron microscopy. The thymic nurse cell (TNC) consists of an epithelial reticular cell (type II) enclosing thymocytes. The TNC exists as a sealed structure in situ, i.e. the lymphocytes within the TNC are isolated from the general thymic environment. TNC are located in the cortex, where mature ...epithelioreticular cell type II; thymic nurse cellPoja Histology Collection - Lymphatic Tissues and Organs Subset
24 Scheme of lymph node (human)Lymph node: A. survey; B. detail subcapsular (or marginal) sinus 1. adipose tissue; 2. capsule; 3. afferent lymph vessel with valves (B); 4. subcapsular (or marginal) sinus; 5. germinal centre of a secondary lymphatic nodule (or follicle); 6. crescent or mantle zone indicated by cap of per...cortex; scheme; paracortex; germinal centerPoja Histology Collection - Lymphatic Tissues and Organs Subset
25 Afferent lymph vessel in lymph node (human)Stain: Azan. Left (A) and right (B): part of the cortex of a lymph node with the capsule (1) and subcapsular (or marginal) sinus (2) filled with lymphocytes. Left (A): (3) show perpendicularly localized reticular cells and fibres (blue) in the sinus. (4) indicate afferent lymph vessel with valves ...lymph vessel; subcapsular sinus; follicle; cortexPoja Histology Collection - Lymphatic Tissues and Organs Subset
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