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TitleDescriptionSubjectCollection
1 Peroxidase reaction in reticular cell and myelocytes (postnatal liver, rat)Electron microscopy (peroxidase reaction with diaminobenzidin staining). The elongated reticular cell (1) shows peroxidase activity within the perinuclear space as well as the rough endoplasmic reticulum (species-dependent). It is surrounded by three eosinophilic myelocytes (2) with a positive react...Poja Histology Collection - Blood & Bone Marrow Subset
2 Plasma cell (liver, rat)Electron microscopy. The mature plasma cell or plasmacyte shows an eccentric nucleus with a characteristic chunky distribution of heterochromatin along the inner nuclear membrane (spoke-wheel effect in light microscopy). Juxtanuclearly an elaborate Golgi area (2) (cytocentrum/centrosome). The cytopl...Poja Histology Collection - Blood & Bone Marrow Subset
3 Three basophilic erythroblasts in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). Three basophilic erythroblasts (1) with intense blue stained cytoplasm, and some so called ears or cytoplasmic projections (arrows). Chromatin strands are thicker than in the proerythroblast. Generally no nucleoli are seen. (2) Damaged or smudged eosinophilic myelocy...Poja Histology Collection - Blood & Bone Marrow Subset
4 Polychromatic erythroblasts and neutrophilic granulocytes in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). Three polychromatic erythroblasts or normoblasts (1) and two neutrophils (2). The erythroblasts show light basophilic cytoplasm and well condensed nuclear chromatin. The lower neutrophil (more mature) has a more segmented nucleus than the upper one.Poja Histology Collection - Blood & Bone Marrow Subset
5 Erythron in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The erythron or erythroblastic island consists of a large reticulum cell (1) surrounded by erythroblastic cell types (2) at varoius stages of differentiation. The nucleus of the reticulum cell (histiocyte) usually contains a noticeable nucleolus. At distance, some my...Poja Histology Collection - Blood & Bone Marrow Subset
6 Mast cell in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The mast cell (1) is characterized by the presence of coarse purple-black granules and a nucleus with oval, central nucleus. The granules contain pharmacologically active mediators such as heparin, histamine, neutrophil- and eosinophil-chemotactic factors, vasoactive...Poja Histology Collection - Blood & Bone Marrow Subset
7 Degenerating granulocytes in peripheral blood smear (human)Stain: May-Grnwald-Giemsa (MGG).Two neutrophils with degenerated nuclei. Note the pyknotic pattern (like mature erythroblast) of the separated and rounded nuclear lobes and the granules in the cytoplasm. Normally only a small number of granulocytes die in the blood.Poja Histology Collection - Blood & Bone Marrow Subset
8 Giant plasma cell in peripheral blood smear (human)Stain: May-Grnwald-Giemsa (MGG). A giant plasma cell with diffusely spread immunoglobulins in the cytoplasm. The Golgi area remains unstained (white area).Poja Histology Collection - Blood & Bone Marrow Subset
9 Vacuolar degeneration of neutrophils in peripheral blood smear (human)Stain: May-Grnwald-Giemsa (MGG). Toxic degeneration of neutrophil resulting in vacuolization of cytoplasm (1); cell with beginning vacuolization (2).Poja Histology Collection - Blood & Bone Marrow Subset
10 Activated lymphocyte (liver inflammation, human)Electron microscopy. A cytotoxic T cell (2) is localized within the sinusoid (3) in the liver (8), surrounded by erythrocytes (1) and debris. The lymphocyte with an irregular indented nucleus shows juxta-nuclearly partly swollen Golgi areas (*) and aggregation of mitochondria (4) in the cytoplasm. F...Poja Histology Collection - Blood & Bone Marrow Subset
11 Monocyte (peripheral blood, human)Electron microscopy. In this picture the large nucleus (1) of this cell (diameter of 12-20 μm) is twice sectioned. Golgi areas (2) and centriole, profiles of rough endoplasmic reticulum (3) and many free ribosomes are present. There are many mitochondria (4) as well as scattered homogeneous electro...Poja Histology Collection - Blood & Bone Marrow Subset
12 Erythroblasts (bone marrow, rabbit)Electron microscopy. (1) shows basophilic erythroblasts or early normoblasts with clumped heterochromatin in the nucleus and numerous polysomes. (1m) points to a mitotic figure of a basophilic erythroblast. A late polychromatic erythroblast or intermediate normoblast (2) marks a maturing stage in wh...Poja Histology Collection - Blood & Bone Marrow Subset
13 Myelopoiesis in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The smear shows a group of myeloid cells in different stages of maturation, in which series the alterations in the nucleus can be noticed clearly going from (1) to (5), i.e. the nucleus gets more and more condensed, indented and subsequently segmented in lobes. (1) p...Poja Histology Collection - Blood & Bone Marrow Subset
14 Basophilic granulocyte in peripheral blood smear (human)Stain: May-Grnwald-Giemsa (MGG). The basophilic granulocyte has large, coarse dark purple-stained granules that contain mediators such as eosinophilic chemotactic factors, heparin, histamine, myeloperoxidase. The nuclear lobes are irregular, badly visible and covered by the granules.Poja Histology Collection - Blood & Bone Marrow Subset
15 Band and hyper segmented neutrophils in peripheral blood smear (human)Stain: May-Grnwald-Giemsa (MGG). (A) shows a young band neutrophil with a non-segmented nucleus. (B) shows mature neutrophils with more than 6 nuclear lobes (hyper segmented). The smear also shows anisocytosis with both microcytes and macrocytes.Poja Histology Collection - Blood & Bone Marrow Subset
16 Survey of bone marrow (bone marrow, rabbit)Electron microscopy. Within the loose reticular tissue a great variety of different stages of young erythrocytes (3, 4) as well as of young granulocytes (5) is present. (2) indicates reticular cells and (2b) phagocytizing reticular cells. (1) fat cells (adipocytes); (6) myeloid cell; (7) capillary.Poja Histology Collection - Blood & Bone Marrow Subset
17 Eosinophilic (meta)myelocyte in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The granules of the eosinophilic (meta)myelocyte (1) are large and brown-blue stained in contrast to the hardly visible, dust-like granules in the neutrophilic band form (2). (3) orthochromatic erythroblast.Poja Histology Collection - Blood & Bone Marrow Subset
18 Granular megakaryocyte producing platelets in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The centrally located megakaryocyte (1) has a huge nucleus (polyploidy) and an extended cytoplasm from which platelets are released at the periphery (arrows).Poja Histology Collection - Blood & Bone Marrow Subset
19 Mast cell (lung, dog)Electron microscopy. This mucosal mast cell of the lung is localized in the vicinity of a blood vessel. Notice the smooth muscle cells (1) of a small arteriole and collagen fibers (2). Most obvious is the presence of granules varying in shape and size. These membrane-bound vesicles (so-called compou...Poja Histology Collection - Blood & Bone Marrow Subset
20 Basophilic granulocyte (peripheral blood, human)Electron microscopy. The bilobed nucleus (2) is surrounded by moderate amount of organelles. The cell exhibits few short filopodia (arrows). The large coarse basophilic granules (1) (specific granules) vary in density and contain vasoactive mediators such as heparin, histamine, sulphated proteoglyca...Poja Histology Collection - Blood & Bone Marrow Subset
21 Mott cell in peripheral blood smear (human)Stain: May-Grnwald-Giemsa (MGG). Plasma cells that contain abundant globular inclusions or vacuoles (Russell bodies) composed of immunoglobulin are called Mott cells (1) morular cells or grape cells. Russell bodies can stain blue-violet or pink but may also be dissolved during fixation and staining....Poja Histology Collection - Blood & Bone Marrow Subset
22 Crista biopsies of normal, hypoplastic and malignant bone marrow (human)Stain: Hematoxylin and eosin. The composition of three slides shows a normal bone marrow section (A), an aplastic bone marrow (B), and a malignant lymphoma in bone marrow (C). (1) Cristae. (2) Fat tissue or fat cells. (3) Erythrocytes and (4) erythroblasts with dark nuclei.Poja Histology Collection - Blood & Bone Marrow Subset
23 Karyorrhexis of polychromatic erythroblast in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The nucleus of the polychromatic erythroblast (1) shows abnormal karyorrhexis due to vitamin B12 deficiency or folic acid deficiency. Normochromic normocyte (2, normal erythrocyte), poikilocytosis and oval macrocytes are seen.Poja Histology Collection - Blood & Bone Marrow Subset
24 Binucleated plasma cell in peripheral blood smear (human)Stain: May-Grnwald-Giemsa (MGG). A large plasma cell with two nuclei. The chromatin is coarsely clumped. The cytoplasm is intensive basophilic due to the large RER content for purpose of antibody production. Note the clear zone (Golgi area) between the nuclei.Poja Histology Collection - Blood & Bone Marrow Subset
25 LymphoblastScheme electron microscopy. The lymphoblast shows a high nucleus-cytoplasm ratio, it is a large cell (10-20 μm) with a large nucleus and distinct nucleolus. Apart from numerous ribosomes, a small juxta-nuclear Golgi area the cytoplasm is scanty with very few organelles.Poja Histology Collection - Blood & Bone Marrow Subset
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