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School Or College
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1,475
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1,352
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792
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764
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633
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628
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Chapter 1 focuses on the inhibition of the β-catenin/B-Cell lymphoma 9 proteinprotein interaction. This protein-protein interaction is found in Wnt signaling and has been strongly linked to cancer. To inhibit the interaction, molecules were computationally designed, synthesized and tested. A series of 33 final compounds was synthesized, resulting in a lead molecule with an inhibition constant of 5.2 μM. The binding mode of this molecule was validated through the structure activity relationship of the series as well as mutational studies. The lead molecule was shown to exhibit 98-fold selectivity for the β-catenin/B-Cell lymphoma 9 interaction over the β-catenin/E-cadherin interaction, inhibit the Wnt pathway in a cell based assay and inhibit the growth of Wnt/β-catenin-dependent cancer cells. Chapter 2 describes an attempt to overexpress and purify the ethylene receptor, a membrane protein found in plants critical to all stages of plant life. There are major unanswered questions involving the ethylene receptor, but most important is the nature of the binding interaction between ethylene and the receptor. We intended to characterize the interaction using a variety of spectral techniques, which would require large amounts of protein. Several strategies to express and purify the receptor were pursued. Chapter 3 lays the foundation for using Stark vibrational spectroscopy to more thoroughly understand the mechanism of proton pumping. Stark vibrational probes were installed in the proton pump ubiquinol oxidase. Functional protein containing the probes iv was successfully expressed and purified. The probes were then utilized to survey the electric field within the proton pump. Changes in electric field were detected in multiple locations and synchronistic results were observed for probes positioned in the same region of the protein. The presented work was highly decoupled and covered a broad area. Completion required efforts in organic synthesis, molecular biology, protein chemistry and spectroscopy. Overall, important foundational achievements were made on several challenging and significant systems.
1
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1
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1
Knitting is one of the most popular techniques to manufacture clothing. In this dissertation we present a framework for modeling, fabricating, and simulating knit structures. We first introduce a fully automatic pipeline to convert arbitrary 3D shapes into a stitch mesh, which provides a mesh-based representation of the yarn-level knit structure. We also extend the concept of stitch mesh modeling with a list of novel shaping techniques to allow modeling more complex structures. We then introduce a scheduling algorithm to convert the structure into step-by-step hand knitting instructions for knitters. We further embed low-level machine knitting operations to each face and allow users to edit the stitch mesh in a way that preserves the machine knittability. Moreover, we present a real-time rendering method to display knitwear containing more than a hundred million individual fiber curves at real-time frame rates with shadows and ambient occlusion on the GPU. We also present a GPU parallelization method to address the computational challenges of using the Material Point Method to simulate knits.
1
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Subject
Utah
267
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123
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114
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113
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100
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63
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53
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49
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48
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47
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46
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45
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40
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39
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38
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36
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35
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35
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33
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32
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31
Medicine
31
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29
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29
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28
Educational psychology
27
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27
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26
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26
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25
Salt Lake City
25
Cancer
24
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24
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24
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24
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24
DNA
23
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23
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22
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21
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20
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19
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19
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19
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19
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18
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18
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18
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18
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17
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United States
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16
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16
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16
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16
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16
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16
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16
Robotics
16
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15
Geology -- Utah -- Box Elder County
15
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15
History
15
Pure sciences
15
Salt Lake County
15
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14
Bioinformatics
14
Data Processing
14
Fatigue
14
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14
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14
Geology -- Utah -- Mineral Mountains
14
Gerontology
14
Pathology
14
Performance
14
Rats
14
Recreation
14
Remote sensing
14
Research Design
14
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14
Therapy
14
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13
Demographic
13
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13
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13
Higher education
13
Kinetics
13
Modern dance
13
Physical education
13
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13
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13
Urban planning
13
Beaver County
12
Behavior
12
China
12
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12
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12
Environmental engineering
12
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12
Grand County
12
Great Salt Lake
12
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12
Linguistics
12
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12
Plans
12
Software
12
Summit County
12
Bonneville
11
Clinical psychology
11
Concrete
11
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11
Gender studies
11
Inflammation
11
MRI
11
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11
Mental health
11
Microfluidics
11
Mining
11
Nanotechnology
11
Nurses
11
Questionnaire
11
RNA
11
Religion
11
Simulation
11
Social sciences
11
Uinta Basin (Utah and Colo.)
11
University of Utah
11
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10
Biophysics
10
Child
10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
Womens studies
10
Adolescent
9
Architecture
9
Climate change
9
Coalville region
9
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9
Culture
9
Early childhood education
9
GPU
9
Geology -- Utah -- Grassy Mountains -- Maps
9
Geology -- Utah -- Lakeside Mountains -- Maps
9
Lake
9
Magnetic resonance imaging
9
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9
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9
Motivation
9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
Wasatch County
9
history
9
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
Nuclear engineering
8
Ore deposits
8
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8
Pyrolysis
8
Rehabilitation
8
Social support
8
Stress
8
Sustainability
8
Visualization
8
Yeast
8
health and environmental sciences
8
Adolescence
7
Adverse Effects
7
Alaska
7
Antibiotics
7
Asphalt
7
CFD
7
Cardiovascular reactivity
7
Catalysis
7
Conflict
7
Design
7
Dopamine
7
Drug Delivery Systems
7
Drugs
7
Electrochemistry
7
Elementary education
7
Ethnic studies
7
Geology -- Utah -- Kane County -- Paria Northwest quadrangle
7
Geology -- Utah -- Summit County
7
Hospitals
7
Hydrogel
7
Intervention
7
Leadership
7
Literature
7
Medical Informatics
7
Military
7
Morphology
7
Parents
7
Perception
7
Petrology -- Utah -- Wasatch Mountains
7
Physiological Effect
7
Prenatal Care
7
Psychotherapy
7
Qualitative research
7
Rat
7
Stratigraphy
7
Taiwan
7
Thin films
7
Turbulence
7
Uinta Basin
7
Virology
7
Wineries
7
education
7
women
7
Aluminum
6
American history
6
Analytical chemistry
6
Antibodies
6
Applied Mathematics
6
Assessment
6
Biosynthesis
6
Breast Cancer
6
Caenorhabditis elegans
6
Climate Change
6
Cognition
6
Complications
6
Corrosion
6
Depression
6
Detection
6
Diseases
6
Electromagnetics
6
Electrophysiology
6
Endocytosis
6
Fire
6
Fluid mechanics
6
Geology--Utah
6
Gilsonite
6
Health Care
6
Health care management
6
Heart
6
Higher Education
6
Individual differences
6
Information science
6
Internet
6
Latter Day Saints
6
Literacy
6
Medical records - Data processing
6
Medicine - Data processing
6
Memory
6
Migration
6
Molecular dynamics
6
Monitoring
6
Mormon
6
Mormonism
6
Navajo Indians
6
Neurology
6
Nurses' Instruction
6
Obstetrical Nursing
6
Organizational behavior
6
PTSD
6
Pediatric Nursing
6
Personality
6
Pharmaceutical sciences
6
Pharmacy
6
Physiological
6
Physiopathology
6
Poetry
6
Psychiatric nursing
6
Public policy
6
Receptors
6
Resilience
6
Sediments (Geology)
6
Signal processing
6
Special education
6
Spectroscopy
6
Surgery
6
Terahertz
6
Transcription Factors
6
Wetlands
6
climate change
6
modeling
6
rhetoric
6
Accounting
5
Algebraic geometry
5
Antigens
5
Archaeology
5
Astrophysics
5
Biochemical
5
Bioretention
5
Blood pressure
5
Care
5
Chemotherapy
5
Clouds
5
Coal liquefaction
5
Compensation
5
Control
5
Copper
5
Creative process
5
Cycloaddition
5
Development
5
Diabetes
5
Diffusion
5
Disability studies
5
Drug delivery
5
Economic theory
5
Empowerment
5
Epigenetics
5
Experiments
5
Father and Child
5
Finance
5
Flotation
5
Foreign body response
5
Framing
5
Gene Expression
5
Geography--Research--United States
5
Geology -- Utah -- Kane County
5
Geothermal
5
Great Salt Lake Basin
5
Growth and Development
5
Heat transfer
5
Heparin
5
Hip
5
Hypertension
5
Individual & family studies
5
Information Technology
5
Intrauterine growth restriction
5
Iron
5
Lake Bonneville
5
Landslides -- Utah -- Kane County
5
Language
5
Learning
5
Localization
5
Marriage
5
Medical imaging
5
Metallurgy
5
Methane
5
Mineral Range (Utah)
5
Mitochondria
5
Mothers
5
Music
5
Mutation
5
Mutations
5
Nationalism
5
Nurse and Patient
5
Oil-shales
5
Older People
5
Ophthalmology
5
Palladium
5
Parenting
5
Pathophysiology
5
Patient Satisfaction
5
Petrology -- Utah -- Beaver County
5
Physiological psychology
5
Policy
5
Polymer
5
Precipitation
5
Preschool
5
Provenance
5
Psychiatric Nursing
5
Psychophysiology
5
Public Health
5
Queer
5
Radar
5
Reading instruction
5
Relationships
5
Research
5
Secondary education
5
Seismic
5
Self-assembly
5
Self-efficacy
5
Shale
5
Silver Island Mountains
5
Smoke prevention
5
Snow
5
TRMM
5
Training
5
Treatment
5
Tumors
5
Turkey
5
Uinta Mountains
5
Ultrasound
5
Urban
5
Ute Indians
5
Virtual reality
5
Water resources management
5
Wireless
5
Youth
5
Zinc -- Metallurgy
5
applied sciences
5
AIDS
4
Aerosol
4
Aerospace engineering
4
Agglomeration
4
Aggression
4
Air pollution
4
American literature
4
Ants
4
Applied mathematics
4
Attachment
4
Attention
4
Autism spectrum disorders
4
Basalt -- Utah
4
Biography
4
Biomass
4
Blasting
4
Blood
4
Blood Pressure
4
Blood flow
4
Body image
4
Botany
4
Box Elder County
4
Breast cancer
4
Breastfeeding
4
Bryostatin
4
Cardiac
4
Caring
4
Cells
4
Cellular Biology
4
Characterization
4
Chromatography
4
Coal mines and mining
4
Collaboration
4
Colonialism
4
Communications
4
Compilers
4
Composites
4
Composition
4
Connectomics
4
Conservation
4
Convection
4
Couples
4
Data analysis
4
Decision Making
4
Decision making
4
Demographic Data
4
Demographics
4
Density functional theory
4
Deposition
4
Dielectric
4
Disability
4
Drug-Related Side Effects and Adverse Reactions
4
ESL
4
Ecocriticism
4
Electric prospecting
4
Electrodeposition
4
Electrowinning
4
Emotions
4
Endocrinology
4
Environmental Health
4
Environmental science
4
Escherichia coli
4
Ethnicity
4
Evaluation Studies
4
Experimental psychology
4
FLAC
4
Family Planning
4
Feminism
4
Fetal growth retardation
4
Fiction
4
Finite element analysis
4
Flow
4
Fracture
4
Gasification
4
Genes
4
Geology -- Structural -- Utah -- Willard Peak area
4
Geology -- Utah -- Weber County
4
Geometry
4
Glaciology
4
Globalization
4
Grammar
4
Graphics
4
Gravity
4
Green River Formation
4
Groundwater
4
HIV
4
HPC
4
Health Education
4
Heterogeneity
4
High temperature
4
Human
4
Hurricanes
4
Hydraulic Fracturing
4
Hydrogen
4
Hydrometallurgy
4
Idaho
4
Immigration
4
Impact
4
India
4
Induced polarization
4
Infant
4
Infant, Newborn
4
Infants
4
Infection
4
Information technology
4
Inorganic chemistry
4
Instrumentation
4
Insulin resistance
4
Integrated circuits
4
Interpersonal
4
Intimate partner violence
4
Iran
4
Israel
4
Journalism
4
Juab County
4
Kaolinite
4
Kenya
4
LDS Hospital
4
LGBTQ studies
4
Labor unions
4
Large-eddy simulation
4
Leaching
4
Lesbian
4
Lidar
4
Longitudinal
4
MPI
4
Macrophage
4
Magnetic resonance
4
Marketing
4
Masculinity
4
Mathematical models
4
Measurement
4
Medical Care
4
Medical Informatics Computing
4
Medical Records
4
Mercury
4
Methylation
4
Midwifery
4
Mines and mineral resources -- Utah -- Deep Creek Mountains
4
Mining engineering
4
Mother-Child Relations
4
Movement
4
Nanoparticles
4
Nanopore
4
Networks
4
Nickel
4
Numerical modeling
4
Numerical simulation
4
Oil sands, Utah
4
Optical
4
Organization and Administration
4
PCR
4
Palestine
4
Parent and Child
4
Patient Care Planning
4
Patient Education
4
Pedagogy
4
Permeability
4
Personality psychology
4
Personnel Management
4
Petroleum
4
Pharmaceuticals
4
Place
4
Pollen
4
Polygamy
4
Postnatal Care
4
Poverty
4
Pregnancy
4
Prevention and Control
4
Protocols
4
Psychological
4
Puerperium
4
Radiology, Medical
4
Reading
4
Recovery
4
Research design
4
Reservoir
4
Risk Factors
4
Rocks
4
Safety
4
Sandstone
4
Screening
4
Second language acquisition
4
Sedimentology
4
Seismology
4
Self-regulation
4
Sequestration
4
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Author
Title
Subject
Date
Publication Type
1276
Margraf, Rebecca Lynn
Characterization of Pactolus: transcription and function
Mice; Neutrophil; Gene Regulation
2003-05
dissertation
1277
Saffioti, Jami Marie
Characterization of pediatric ocular material properties for implementation in finite element modeling
Biomechanics; Eye; Finite element modeling; Material properties; Ocular; Pediatrics
2014-08
dissertation
1278
Shiflett, Shelly Lynn
Characterization of proteins regulating vesicular trafficking and protein sorting
Physiology; Amino Acids
2004-08
dissertation
1279
Crossman, Raquel
Characterization of rare earth particles from the Florida phosphate industry through dual energy radiography and x-ray tomography
Dual energy radiography; Phosphate industry; Rare earth elements; X-ray tomography
2014-12
thesis
1280
Novak, Jeanne Marie
Characterization of receptor redistribution and regulatory volume decrease in rabbit alveolar macrophages
Physiology; Rabbits; Signal Transduction
1987-12
dissertation
1281
Komanetsky, Susan M.
Characterization of retinol binding protein receptor 2, a putative retinol transporter and serum retinol binding protein receptor
Insulin resistance; RBP4; RBP4 receptor; Retinol; Retinol homeostasis; Retinol transport
2013-05
thesis
1282
Howe, Julia Corbett
Characterization of segmentation and long-term vertical slip rates of the wasatch fault zone, utah
Lake Bonneville; lidar; python; shorelines; Wasatch Fault Zone
2017
thesis
1283
Huang, Simin
Characterization of shallow shear wave velocity structures in Southwestern Utah
Microtremor; Seismic; Shallow shear wave velocity; Southwestern Utah; St. George; Cedar City; Earthquakes; Seismometers
2011-05
thesis
1284
Maestas, Melissa May
Characterization of speciated atmospheric mercury concentration measurements in Northern Utah
GEM; GOM; Atmospheric mercury; PBM; Northern Utah; Atmospheric Chemistry; Atmospheric sciences
2011-12
thesis
1285
Timpson, Thomas Cawley
Characterization of strength and deformation properties of rock material for design of drilled shafts under lateral load
Laterally loaded drilled shaft; Rock characterization; Strength characterization; Geotechnical engineering
2011-12
thesis
1286
Ebbert, Mark Tyler Wilkinson
Characterization of technical uncertainty in the classification of centroid-based multivariate assays
2012-08
thesis
1287
Hammond, Saher Sue
Characterization of the genetic and epigenetic status of fertile and fertile men
2011-05
dissertation
1288
Sankar, Savita
Characterization of the mechanisms of transcriptional regulation by EWS/FLI in ewing sarcoma
2013-08
dissertation
1289
Ward, Diana McVey.
Characterization of the movement of receptors and ligands through the endocytic apparatus in alveolar macrophages.
Ligand-Receptor Complexes; Cells
1991-03
dissertation
1290
Xu, Gangfeng Cloning
Characterization of the NF1 gene and its gene product, neurofibromin.
cDNA; Genes
1994-08
dissertation
1291
Bokil, Mukul
Characterization of the pressure wave from a shock tube using numerical simulations
Blast; Brain; Numerical; Pressure; Shock tube; Pressure wave; TBI; Blast wave
2010-08
thesis
1292
Landesman, Michael Benjamin
Characterization of the retroviral budding factor ALIX
2012-05
dissertation
1293
Sonderegger, F. Lynn
Characterization of the source and function of interleukin-10 during lyme arthritis development
2011-12
dissertation
1294
Moran, Patrick Ryan
Characterization of the vitreoretinal interface and vitreous in the porcine eye as it changes with age
Mechanics, Porcine, Vitreous
2012-12
thesis
1295
Kasten, Margaret Marie
Characterization of the yeast Sin3 repressor complex
1996-12
dissertation
1296
Higa, Meda Michiko
Characterization of the zinc finger domain of the nuclear pore protein Nup153
Proteins; Membranes; Cellular Processes
2007-05
dissertation
1297
Wang, Hongfang
Characterization of thymocyte progenitors in adult bone marrow and effects of cytokines on T cell development
Bone Marrow; Cell Differentiation
2006-12
dissertation
1298
Li, Liangtao
Characterization of yeast genes involved in intracellular iron homeostatis
Metabolism; Metal Sensitivity
1998-12
thesis
1299
Wright, William Evan
Characterization of zeolite fibers using scanning electron microscopy.
Borosilicate Glass; Mesothelimoa
1979-08
thesis
1300
Mejia, Joel Alejandro
Characterization, analysis and simulation of fine coal filtration
Coal; Filtration; HRXMT; Lattice-Boltzmann; Pore network structure; X-ray microtomography
2013-08
thesis
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