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School Or College
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1,475
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1,352
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792
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764
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633
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628
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Chapter 1 focuses on the inhibition of the β-catenin/B-Cell lymphoma 9 proteinprotein interaction. This protein-protein interaction is found in Wnt signaling and has been strongly linked to cancer. To inhibit the interaction, molecules were computationally designed, synthesized and tested. A series of 33 final compounds was synthesized, resulting in a lead molecule with an inhibition constant of 5.2 μM. The binding mode of this molecule was validated through the structure activity relationship of the series as well as mutational studies. The lead molecule was shown to exhibit 98-fold selectivity for the β-catenin/B-Cell lymphoma 9 interaction over the β-catenin/E-cadherin interaction, inhibit the Wnt pathway in a cell based assay and inhibit the growth of Wnt/β-catenin-dependent cancer cells. Chapter 2 describes an attempt to overexpress and purify the ethylene receptor, a membrane protein found in plants critical to all stages of plant life. There are major unanswered questions involving the ethylene receptor, but most important is the nature of the binding interaction between ethylene and the receptor. We intended to characterize the interaction using a variety of spectral techniques, which would require large amounts of protein. Several strategies to express and purify the receptor were pursued. Chapter 3 lays the foundation for using Stark vibrational spectroscopy to more thoroughly understand the mechanism of proton pumping. Stark vibrational probes were installed in the proton pump ubiquinol oxidase. Functional protein containing the probes iv was successfully expressed and purified. The probes were then utilized to survey the electric field within the proton pump. Changes in electric field were detected in multiple locations and synchronistic results were observed for probes positioned in the same region of the protein. The presented work was highly decoupled and covered a broad area. Completion required efforts in organic synthesis, molecular biology, protein chemistry and spectroscopy. Overall, important foundational achievements were made on several challenging and significant systems.
1
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1
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1
Knitting is one of the most popular techniques to manufacture clothing. In this dissertation we present a framework for modeling, fabricating, and simulating knit structures. We first introduce a fully automatic pipeline to convert arbitrary 3D shapes into a stitch mesh, which provides a mesh-based representation of the yarn-level knit structure. We also extend the concept of stitch mesh modeling with a list of novel shaping techniques to allow modeling more complex structures. We then introduce a scheduling algorithm to convert the structure into step-by-step hand knitting instructions for knitters. We further embed low-level machine knitting operations to each face and allow users to edit the stitch mesh in a way that preserves the machine knittability. Moreover, we present a real-time rendering method to display knitwear containing more than a hundred million individual fiber curves at real-time frame rates with shadows and ambient occlusion on the GPU. We also present a GPU parallelization method to address the computational challenges of using the Material Point Method to simulate knits.
1
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Subject
Utah
267
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123
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114
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113
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100
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63
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53
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49
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48
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47
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46
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45
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40
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39
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38
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36
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35
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35
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33
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32
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31
Medicine
31
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29
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29
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28
Educational psychology
27
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27
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26
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26
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25
Salt Lake City
25
Cancer
24
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24
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24
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24
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24
DNA
23
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23
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22
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21
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20
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19
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19
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19
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19
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18
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18
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18
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18
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17
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United States
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16
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16
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16
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16
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16
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16
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16
Robotics
16
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15
Geology -- Utah -- Box Elder County
15
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15
History
15
Pure sciences
15
Salt Lake County
15
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14
Bioinformatics
14
Data Processing
14
Fatigue
14
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14
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14
Geology -- Utah -- Mineral Mountains
14
Gerontology
14
Pathology
14
Performance
14
Rats
14
Recreation
14
Remote sensing
14
Research Design
14
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14
Therapy
14
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13
Demographic
13
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13
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13
Higher education
13
Kinetics
13
Modern dance
13
Physical education
13
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13
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13
Urban planning
13
Beaver County
12
Behavior
12
China
12
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12
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12
Environmental engineering
12
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12
Grand County
12
Great Salt Lake
12
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12
Linguistics
12
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12
Plans
12
Software
12
Summit County
12
Bonneville
11
Clinical psychology
11
Concrete
11
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11
Gender studies
11
Inflammation
11
MRI
11
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11
Mental health
11
Microfluidics
11
Mining
11
Nanotechnology
11
Nurses
11
Questionnaire
11
RNA
11
Religion
11
Simulation
11
Social sciences
11
Uinta Basin (Utah and Colo.)
11
University of Utah
11
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10
Biophysics
10
Child
10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
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10
Womens studies
10
Adolescent
9
Architecture
9
Climate change
9
Coalville region
9
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9
Culture
9
Early childhood education
9
GPU
9
Geology -- Utah -- Grassy Mountains -- Maps
9
Geology -- Utah -- Lakeside Mountains -- Maps
9
Lake
9
Magnetic resonance imaging
9
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9
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9
Motivation
9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
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9
Wasatch County
9
history
9
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
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8
Nuclear engineering
8
Ore deposits
8
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8
Pyrolysis
8
Rehabilitation
8
Social support
8
Stress
8
Sustainability
8
Visualization
8
Yeast
8
health and environmental sciences
8
Adolescence
7
Adverse Effects
7
Alaska
7
Antibiotics
7
Asphalt
7
CFD
7
Cardiovascular reactivity
7
Catalysis
7
Conflict
7
Design
7
Dopamine
7
Drug Delivery Systems
7
Drugs
7
Electrochemistry
7
Elementary education
7
Ethnic studies
7
Geology -- Utah -- Kane County -- Paria Northwest quadrangle
7
Geology -- Utah -- Summit County
7
Hospitals
7
Hydrogel
7
Intervention
7
Leadership
7
Literature
7
Medical Informatics
7
Military
7
Morphology
7
Parents
7
Perception
7
Petrology -- Utah -- Wasatch Mountains
7
Physiological Effect
7
Prenatal Care
7
Psychotherapy
7
Qualitative research
7
Rat
7
Stratigraphy
7
Taiwan
7
Thin films
7
Turbulence
7
Uinta Basin
7
Virology
7
Wineries
7
education
7
women
7
Aluminum
6
American history
6
Analytical chemistry
6
Antibodies
6
Applied Mathematics
6
Assessment
6
Biosynthesis
6
Breast Cancer
6
Caenorhabditis elegans
6
Climate Change
6
Cognition
6
Complications
6
Corrosion
6
Depression
6
Detection
6
Diseases
6
Electromagnetics
6
Electrophysiology
6
Endocytosis
6
Fire
6
Fluid mechanics
6
Geology--Utah
6
Gilsonite
6
Health Care
6
Health care management
6
Heart
6
Higher Education
6
Individual differences
6
Information science
6
Internet
6
Latter Day Saints
6
Literacy
6
Medical records - Data processing
6
Medicine - Data processing
6
Memory
6
Migration
6
Molecular dynamics
6
Monitoring
6
Mormon
6
Mormonism
6
Navajo Indians
6
Neurology
6
Nurses' Instruction
6
Obstetrical Nursing
6
Organizational behavior
6
PTSD
6
Pediatric Nursing
6
Personality
6
Pharmaceutical sciences
6
Pharmacy
6
Physiological
6
Physiopathology
6
Poetry
6
Psychiatric nursing
6
Public policy
6
Receptors
6
Resilience
6
Sediments (Geology)
6
Signal processing
6
Special education
6
Spectroscopy
6
Surgery
6
Terahertz
6
Transcription Factors
6
Wetlands
6
climate change
6
modeling
6
rhetoric
6
Accounting
5
Algebraic geometry
5
Antigens
5
Archaeology
5
Astrophysics
5
Biochemical
5
Bioretention
5
Blood pressure
5
Care
5
Chemotherapy
5
Clouds
5
Coal liquefaction
5
Compensation
5
Control
5
Copper
5
Creative process
5
Cycloaddition
5
Development
5
Diabetes
5
Diffusion
5
Disability studies
5
Drug delivery
5
Economic theory
5
Empowerment
5
Epigenetics
5
Experiments
5
Father and Child
5
Finance
5
Flotation
5
Foreign body response
5
Framing
5
Gene Expression
5
Geography--Research--United States
5
Geology -- Utah -- Kane County
5
Geothermal
5
Great Salt Lake Basin
5
Growth and Development
5
Heat transfer
5
Heparin
5
Hip
5
Hypertension
5
Individual & family studies
5
Information Technology
5
Intrauterine growth restriction
5
Iron
5
Lake Bonneville
5
Landslides -- Utah -- Kane County
5
Language
5
Learning
5
Localization
5
Marriage
5
Medical imaging
5
Metallurgy
5
Methane
5
Mineral Range (Utah)
5
Mitochondria
5
Mothers
5
Music
5
Mutation
5
Mutations
5
Nationalism
5
Nurse and Patient
5
Oil-shales
5
Older People
5
Ophthalmology
5
Palladium
5
Parenting
5
Pathophysiology
5
Patient Satisfaction
5
Petrology -- Utah -- Beaver County
5
Physiological psychology
5
Policy
5
Polymer
5
Precipitation
5
Preschool
5
Provenance
5
Psychiatric Nursing
5
Psychophysiology
5
Public Health
5
Queer
5
Radar
5
Reading instruction
5
Relationships
5
Research
5
Secondary education
5
Seismic
5
Self-assembly
5
Self-efficacy
5
Shale
5
Silver Island Mountains
5
Smoke prevention
5
Snow
5
TRMM
5
Training
5
Treatment
5
Tumors
5
Turkey
5
Uinta Mountains
5
Ultrasound
5
Urban
5
Ute Indians
5
Virtual reality
5
Water resources management
5
Wireless
5
Youth
5
Zinc -- Metallurgy
5
applied sciences
5
AIDS
4
Aerosol
4
Aerospace engineering
4
Agglomeration
4
Aggression
4
Air pollution
4
American literature
4
Ants
4
Applied mathematics
4
Attachment
4
Attention
4
Autism spectrum disorders
4
Basalt -- Utah
4
Biography
4
Biomass
4
Blasting
4
Blood
4
Blood Pressure
4
Blood flow
4
Body image
4
Botany
4
Box Elder County
4
Breast cancer
4
Breastfeeding
4
Bryostatin
4
Cardiac
4
Caring
4
Cells
4
Cellular Biology
4
Characterization
4
Chromatography
4
Coal mines and mining
4
Collaboration
4
Colonialism
4
Communications
4
Compilers
4
Composites
4
Composition
4
Connectomics
4
Conservation
4
Convection
4
Couples
4
Data analysis
4
Decision Making
4
Decision making
4
Demographic Data
4
Demographics
4
Density functional theory
4
Deposition
4
Dielectric
4
Disability
4
Drug-Related Side Effects and Adverse Reactions
4
ESL
4
Ecocriticism
4
Electric prospecting
4
Electrodeposition
4
Electrowinning
4
Emotions
4
Endocrinology
4
Environmental Health
4
Environmental science
4
Escherichia coli
4
Ethnicity
4
Evaluation Studies
4
Experimental psychology
4
FLAC
4
Family Planning
4
Feminism
4
Fetal growth retardation
4
Fiction
4
Finite element analysis
4
Flow
4
Fracture
4
Gasification
4
Genes
4
Geology -- Structural -- Utah -- Willard Peak area
4
Geology -- Utah -- Weber County
4
Geometry
4
Glaciology
4
Globalization
4
Grammar
4
Graphics
4
Gravity
4
Green River Formation
4
Groundwater
4
HIV
4
HPC
4
Health Education
4
Heterogeneity
4
High temperature
4
Human
4
Hurricanes
4
Hydraulic Fracturing
4
Hydrogen
4
Hydrometallurgy
4
Idaho
4
Immigration
4
Impact
4
India
4
Induced polarization
4
Infant
4
Infant, Newborn
4
Infants
4
Infection
4
Information technology
4
Inorganic chemistry
4
Instrumentation
4
Insulin resistance
4
Integrated circuits
4
Interpersonal
4
Intimate partner violence
4
Iran
4
Israel
4
Journalism
4
Juab County
4
Kaolinite
4
Kenya
4
LDS Hospital
4
LGBTQ studies
4
Labor unions
4
Large-eddy simulation
4
Leaching
4
Lesbian
4
Lidar
4
Longitudinal
4
MPI
4
Macrophage
4
Magnetic resonance
4
Marketing
4
Masculinity
4
Mathematical models
4
Measurement
4
Medical Care
4
Medical Informatics Computing
4
Medical Records
4
Mercury
4
Methylation
4
Midwifery
4
Mines and mineral resources -- Utah -- Deep Creek Mountains
4
Mining engineering
4
Mother-Child Relations
4
Movement
4
Nanoparticles
4
Nanopore
4
Networks
4
Nickel
4
Numerical modeling
4
Numerical simulation
4
Oil sands, Utah
4
Optical
4
Organization and Administration
4
PCR
4
Palestine
4
Parent and Child
4
Patient Care Planning
4
Patient Education
4
Pedagogy
4
Permeability
4
Personality psychology
4
Personnel Management
4
Petroleum
4
Pharmaceuticals
4
Place
4
Pollen
4
Polygamy
4
Postnatal Care
4
Poverty
4
Pregnancy
4
Prevention and Control
4
Protocols
4
Psychological
4
Puerperium
4
Radiology, Medical
4
Reading
4
Recovery
4
Research design
4
Reservoir
4
Risk Factors
4
Rocks
4
Safety
4
Sandstone
4
Screening
4
Second language acquisition
4
Sedimentology
4
Seismology
4
Self-regulation
4
Sequestration
4
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4
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Author
Title
Subject
Date
Publication Type
1176
Nelson, Bill Jacob
Case studies of selected Spanish-American junior and senior high school students from Lark, Utah
1969
thesis
1177
Li, Lingkun
Case studies on free drying shrinkage test sensitivity and on carbonation rate of mortar with photocatalytics
Carbonation; Concrete; Free Shrinkage; Titanium Dioxide
2017
thesis
1178
Newton, Kathryn Turner
Case study approach to health science: design and implementation of an online course
Online Courses; Implementation; Technology
2001-08
thesis
1179
Sriramasamudram, Jai K
Case study of turbulent fluxes during a wintertime persistent cold air pool in the Salt Lake Valley
Cold air pool; Inversion; Meterology; Persistent cold air pool; Turbulence
2010-07
thesis
1180
Kee, Helen Klutcher
Case study of two complex health care institutions with charging systems for nursing care
Economics; Nursing Services; Reimbursement Mechanisms
1988-06
dissertation
1181
Hannah, Richard Lloyd
Case study of underground coal mining productivity in Utah
Coal mines and mining; Coal miners; Coal trade
1981-12
dissertation
1182
Eide, Erik John
Casein kinase 1 epsilon regulates transcription and Period2 stability within the mammalian circadian clock
2003-12
dissertation
1183
Vanderloo, Mindy J.
Caseworker factors that influence removal decisions in child welfare investigations
Social work; Individual & family studies
2017
dissertation
1184
Brewer, Kenneth Wayne
Catching light a collection of poems
1973
dissertation
1185
Crockett, Ashley Anne
Categorizing content in digital resources for education: developing a rubric to represent the selection and use of online materials
2019
thesis
1186
Rullo, Jordan Elizabeth
Category-specificity in sexual arousal/interest as a complex function of sex and sexual orientation
Gays; Lesbians; Sexual excitement
2008-01-30
thesis
1187
Betlemidze, Mariam
Caucasian conflicts and the way out of deadlock through cultural affirmative philosophy
Citizen journalism; Conflict resolution; Cyber war; Hactivism; Media; War machines; Nagorno-Karabakh Conflict, 1988-1994
2012-05
thesis
1188
Figueroa, Richard
The causal efficacy of conservation actions for preserving the short-term evolvability of wild popluations
Philosophy of Science; Conservation biology; Evolution and Development
2017
thesis
1189
Erspamer, Bryan Thomas
Causes of hip pain in collegiate ice hockey players
Medicine; Pathology
2018
thesis
1190
Das, Gaurav
Cell cycle mediated regulation of retinal development: insights from D-Cyclin knockout mice
2010-08
dissertation
1191
Kang, Hara
Cell cycle, fate, stem cells, and the planarian schmidtea mediterranea
2009-05
dissertation
1192
Zabel, Mark Douglas
Cell specific expressions of the murine CD21 gene.
Genetic Regulation; Mice; Immunology
2001-12
dissertation
1193
Daniel Yongwon Lee
Cell surface engineering and its applications in cancer therapy
Cellular biology; Biomedical engineering; Pharmaceutical sciences
2017
dissertation
1194
Suh, Won-Hee
Cell-specific targeting polymeric gene delivery carriers
Drug Delivery Systems; Polymeric Drugs
2001-08
dissertation
1195
Portereiko, Michael F.
Cellular and genetic analysis of pharyngeal morphogenesis in Caenorhabditis elegans
Pharyngeal Cells; Cytokinesis Defects; Pharyngeal Morphogenesis
2003-08
dissertation
1196
Xing, Lingyan
Cellular and molecular analysis of axon development in zebrafish
2015-12
dissertation
1197
Park, Eon Joo
Cellular and molecular mechanisms of FGF8 signaling in cardiac outflow tract development and remodeling
2009-08
dissertation
1198
Teuscher, Kevin Bruce
Cellular bioavailability of small-molecule inhibitors and optimization of small-molecule inhibitors for b-catenin mediation protein=protein interactions
2018
dissertation
1199
Hao, Huaixiang
Cellular energy homeostasis: a nutrient sensing kinase and a mitochondrial tumor suppressor
2009-08
dissertation
1200
Garrus, Jennifer E.
Cellular factors and HIV-1 budding.
Proteins; AIDS:
2003-05
dissertation
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