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1 Walsh & Hoyt: Leber's Optic NeuropathyIn 1871, Leber first described the disease that bears his name, although similar cases were reported 50 years earlier.Leber's Optic NeuropathyNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
2 Walsh & Hoyt: Disorders of MitochondriaThe mitochondrial encephalomyopathies are caused by defects in oxidative phosphorylation in mitochondria. Energy-dependent tissues are most vulnerable. These include muscle, brain, retina, and optic nerve. These diseases may be caused by mutations of either the mitochondrial DNA or nuclear DNA. Diso...Neurodegenerative Diseases; Metabolic Diseases; Infant; Child; Mitochondria DisordersNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
3 Walsh & Hoyt: Leber's Optic NeuropathyIn 1871, Leber first described the disease that bears his name, although similar cases were reported 50 years earlier (e.g., von Graefe in 1858). Leber considered this entity an inflammatory neuritis, but others supported an abiotrophic origin. Numerous pedigrees of Lebers hereditary optic neuropath...Optic Nerve Diseases; Genetic Diseases, Inborn; Leber's Optic NeuropathyNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
4 Walsh & Hoyt: Afferent AbnormalitiesAfferent abnormalities. Relative afferent pupillary defect. The relative afferent pupillary defect (RAPD) is one of the most important objective signs of dysfunction in the afferent visual pathway. The methods of RAPD detection and quantification were reviewed in Chapter 15. In this section, we disc...Ocular Motor System; Accommodation, Ocular; Tears; Relative Afferent Pupillary Defect; Optic Nerve Disorders; Leber Hereditary Optic Neuropathy; Retinal Disease; Assymetrical Retinal Adaptation; Amblyopia; Media Opacities; Optic Tract Disorders; RAPD; Afferent Pupillary DefectNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
5 Walsh & Hoyt: Differential Diagnosis of Optic AtrophyWhen optic atrophy is complete, it is often impossible to determine its etiology solely from its appearance. Trobe et al. viewed 163 color fundus stereophotographs of nine disease entities: glaucoma, central retinal artery occlusion, ischemic optic neuropathy, anterior and retrobulbar optic neuritis...Optic Nerve Diseases; Eye Abnormalities; Visual Impairments; Optic Atrophy; Differential DiagnosisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
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