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Aquaporumab: An Anti-Aquaporin-4 Monoclonal Antibody Blocker Therapy for Neuromyelitis Optica | Jeffrey Bennett; Lukmanee Tradtrantip; Hua Zhang; Samira Saadoun; Puay-Wah Phuan; Chiwah Lam; Marios Papadopoulos; Alan Verkman | Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that predominantly affects the optic nerves and spinal cord. Circulating autoantibodies (NMO-IgG) against the astrocyte water channel aquaporin-4 (AQP4) cause complement- and cell-mediated astrocyte damage with consequent neuroinfla... | 20120213_nanos_sciplatform_03 |