NOVEL - NANOS Annual Meeting
 
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1 Jacobson Lecture - Pediatric Pseudotumor Cerebri Syndrome: A JourneyIC-E10ai-intracranial-hypertensionMany of Daniel Jacobson's papers were based upon careful observations and important questions arising in neuro-ophthalmic patients he saw in his practice. This year's speaker, Grant Liu, has emulated this approach in his academic career. This talk will highlight Dr. Liu's contributions to the unders...Diagnostics; Pediatrics; Pseudotumor CerebriNeuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
2 A Randomized Controlled, Trial of the GLP-1 Receptor Agonist Exenatide in Idiopathic Intracranial HypertensionPre-clinical data demonstrates the ability of Exenatide, a GLP-1R agonist, to reduce CSF secretion and ICP.1 Existing GLP- 1R agonists are widely used to treat obesity and diabetes (but do not cause hypoglycaemia).Pseudotumor Cerebri; High Intracranial Pressure/HeadacheNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
3 Swelling of Atrophic Optic Discs in Idiopathic Intracranial HypertensionMonitoring patients with idiopathic intracranial hypertension (IIH) who have optic atrophy may be difficult as papilledema may not be appreciable on ophthalmoscopy. This retrospective chart review is the first study to evaluate whether recurrence of papilledema can be detected in this population usi...Pseudotumor Cerebri; Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc); Optic NeuropathyNeuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
4 Intra-Cranial Pressure in Idiopathic Intracranial Hypertension, Insights From Long-Term Telemetric MonitoringThe objectives of this study were to assess postural changes in Idiopathic Intracranial Hypertension (IIH), to assess diurnal variation in IIH and to assess variation in ICP over time with serial measurements.Pseudotumor Cerebri; High Intracranial Pressure/HeadacheNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
5 When You Hear HoofbeatsA 27-year-old woman is admitted in July 2020 for severe vision loss secondary to "pseudotumor cerebri (PTC)". Two years previously (July 2018), she developed headache, blurred vision, papilledema, and seizure at 34 weeks' gestation. She was diagnosed to have eclampsia and underwent urgent c-section.Papilledema; Increased Intracranial Pressure; Intracranial TumorsNeuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
6 Effect of Prostaglandin Analogs on Cerebrospinal Fluid Reabsorption Via Nasal MucosaCerebrospinal fluid (CSF) outflow has been demonstrated along nasal lymphatics via olfactory nerve projections; flow may be increased by stimulating lymphatic contractility using agents such as noradrenaline and the thromboxane A2 analog U46619. Lymphatics elsewhere in the body show increased contra...High Intracranial Pressure/headache; Pseudotumor CerebriNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
7 Elevated Intracranial Pressures and Papilledema in a Mouse Model of Glucocorticoid Induced Adrenal InsufficiencyMechanisms underlying elevated intracranial pressure (ICP) in idiopathic intracranial hypertension (IIH) are poorly understood. Several recent cases have implied adrenal function to contribute to the pathophysiology of IIH, but no studies have examined this relationship to date. Using a mouse model ...Pseudotumor Cerebri; High Intracranial Pressure/Headache; Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc)Neuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
8 Headache Management in IIHHeadache is a common symptom when patients initially develop idiopathic intracranial hypertension (IIH) or intracranial hypertension from a secondary cause. While the headache often improves with intracranial pressure lowering therapies, it becomes a chronic problem and a long-term management challe...Idiopathic Intracranial Hypertension; Headache; Medication Overuse Headache; Pseudotumor CerebriNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
9 Pseudo-Pseudotumor Cerebri?A 23-year-old female to male transgender patient (BMI=30) on testosterone therapy presented to the urgent clinic with bilateral disc swelling and preserved optic disc function (Figure 1a-1b). He had a 5 day history of general malaise. Past medical history was pertinent for scoliosis surgery at age 1...Intracranial Tumors; Increased Intracranial Pressure; Vision Loss; Complications of CancersNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
10 Retinal Vessel Dynamics as a Surrogate Marker for Intracranial Pressure in Idiopathic Intracranial HypertensionMonitoring intracranial pressure (ICP) is hard to achieve but desirable for successful management of idiopathic intracranial hypertension (IIH). Diagnosis is primarily based on lumbar puncture (LP) opening pressure (OP) and there is an unmet need for a non-invasive and reliable method for long term ...High Intracranial Pressure/Headache; Retina; Pseudotumor CerebriNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
11 Significance of Incidental Imaging Signs of Intracranial Hypertension with Corresponding Fundus Photography: A Prospective StudyMRI signs suggesting intracranial hypertension are common in patients with idiopathic intracranial hypertension (IIH), but are also incidentally detected in asymptomatic patients and those with primary headache syndromes, prompting neuro-ophthalmology consultations and investigations.1-3 We aimed to...High Intracranial Pressure/Headache; Neuroimaging; Pseudotumor CerebriNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
12 Artificial Intelligence Reveals Disease-Specific Quantifiable Visual Field Defects in Idiopathic Intracranial HypertensionAssessing regional visual field (VF) changes typically requires qualitative expert or subjective analysis. Archetypal analysis (AA), a type of unsupervised machine learning, has been used to identify and monitor patterns of VF loss in glaucoma. AA has not beenapplied to non-glaucomatous optic neurop...Optic Neuropathy; Pseudotumor Cerebri; Visual FieldsNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
13 Impact of Glucose on Mitochondrial Function in a Brain Slice Model of Headache MechanismsIdiopathic intracranial hypertension (IIH) is a condition of raised intracranial pressure that features debilitating headaches with migraine-like characteristics. Cortical Spreading Depression (CSD), a propagating wave of depolarisation across the cerebral cortex, proposed to activate trigeminal ner...High Intracranial Pressure/Headache; Pseudotumor CerebriNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
14 How Much Weight Loss is Required to Reduce Intracranial Pressure in Idiopathic Intracranial Hypertension?The IIH:WT randomised trial established that weight loss through bariatric surgery significantly reduced intracranial pressure (ICP) at 12 and 24 months as compared to a community weight management intervention (CWI). This study aimed to evaluate the amount of weight loss required to reduce ICP in i...High Intracranial Pressure/headache; Pseudotumor CerebriNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
15 Referral Patterns to Neuro-Ophthalmology for Presumptive Idiopathic Intracranial Hypertension (IIH) Based on Isolated Neuroimaging FindingsRadiologic findings of intracranial hypertension (RAD-IH) are common in IIH patients. Paralleling the increasing rates of obesity, the burden of IIH is growing. Requests for urgent neuro-ophthalmology consultation for "IIH?" in patients incidentally detected to have RAD-IH are increasing, with many ...High Intracranial Pressure/Headache; Pseudotumor Cerebri; NeuroimagingNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
16 Weight Loss in IIHIt has been well known that IIH is associated with obesity. Weight gain is considered a risk factor for disease onset and recurrences. Weight loss has been well documented in several case series to be associated with improvement in symptoms and signs and to be associated with lowering of intracrania...Idiopathic Intracranial Hypertension; Pseudotumor Cerebri; Weight Loss; Treatment; Idiopathic Intracranial Hypertension Treatment TrialNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
17 Weight Loss in IIHIC-G4a-counseling-for-weight-lossIt has been well known that IIH is associated with obesity. Weight gain is considered a risk factor for disease onset and recurrences. Weight loss has been well documented in several case series to be associated with improvement in symptoms and signs and to be associated with lowering of intracrania...Idiopathic Intracranial Hypertension; Pseudotumor Cerebri; Weight Loss; Treatment; Idiopathic Intracranial Hypertension Treatment TrialNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
18 Can We Repeat an ONSF?Idiopathic intracranial hypertension (IIH) is a growing problem associated with headaches but most importantly to ophthalmologists vision loss. For patients with mild to moderate vision loss, medical management is typically sufficient for control of symptoms and resolution of papilledema. However, i...Optic Nerve Sheath Fenestration; Optic Nerve Sheath Decompression; Papilledema; Idiopathic Intracranial Hypertension; Cerebrospinal FluidNeuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
19 Endovascular Venous Stenting for Idiopathic Intracranial Hypertension (IIH)IC-E12ciii-neuro-endovascular-proceduresVenous sinus stenosis has been observed in patients with idiopathic intracranial hypertension (IIH) over the last two decades. Uncertainty remains as to whether this stenosis is the result or cause of intracranial hypertension in certain patients with the disease or whether it may be both. The assoc...Idiopathic Intracranial Hypertension; Venous Sinus Stenosis; Venous Stenting; Venous Sinus Hypertension; Pseudotumor CerebriNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
20 Deep Learning Can Accurately Distinguish Between True Papilledema and Optic Disc Drusen on Fundus PhotographsIdentification of true papilledema due to raised intracranial pressure requires high neuro-ophthalmic expertise and expensive ancillary testing. Its ophthalmoscopic diagnosis can be easily mistaken with false papilledema due to optic disc drusen (ODD), especially if the latter are buried within the ...High Intracranial Pressure/Headache; Optic Neuropathy; Pseudotumor Cerebri; Vascular DisordersNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
21 Ocular Deformities in Spaceflight-Associated Neuro-Ocular Syndrome and Idiopathic Intracranial Hypertension"Spaceflight-Associated Neuro-Ocular Syndrome (SANS)" shares several clinical elements with Idiopathic Intracranial-Hypertension (IIH), namely disc edema, globe-flattening, hyperopic-shift, and choroidal folds. In IIH, globe-flattening is caused by increased intracranial pressure (ICP); the cause in...Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc); Pseudotumor Cerebri; High Intracranial Pressure/Headache; MiscellaneousNeuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
22 Lost in the SauceA 41-year-old male was referred to neuro-ophthalmology for "pseudotumor cerebri and hypertensive retinopathy" and decreased vision. Three months prior the examination, the patient reported a fairly rapid painless decline in the vision in both eyes over a week. He also reported heavy polysubstance ab...Optic Neuropathy; Optic Atrophy; Metabolic Disease; Neurologic Disorders; Vision Loss BinocularNeuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
23 Detection of Papilledema on Non-Mydriatic Ocular Fundus Photography In the Emergency Department: Application of the BONSAI Deep Learning System (DLS) To the FOTO-ED StudyThe FOTO-ED studies showed that ED providers (EDPs) poorly recognized relevant ocular funduscopic findings in patients presenting to the ED with headaches, acute neurologic findings, severe hypertension or visual loss, using direct ophthalmoscopy [0% correctly identified] or on non-mydriatic fundus ...Pseudotumor Cerebri; Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc)Neuro-Ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
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