The Alfredo A. Sadun Neuro-Ophthalmology Collection: A Professor of Ophthalmology and Neurological Surgery at the USC Keck School of Medicine, Dr. Sadun with a team of researchers at the Doheny Eye Institute pioneered research in optic nerve dysfunction in patients with Alzheimer's disease. Contains his "100 best lectures." Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor Ophthalmology & Neurological Surgery, Doheny Eye Institute, Keck School of Medicine at USC.
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| Title | Creator | Description | Subject | Imaging | ||
|---|---|---|---|---|---|---|
| 1 |
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Anatomy and Physiology of the Optic Nerve | Alfredo A. Sadun, MD, PhD | Lecture covering the anatomy and physiology of the optic nerve. Covers the retina and anterior visual pathways. Several slides show microscopic images of optic nerve damage. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma; Anatomy of the Optic Nerve; AVP Optic Nerve | |
| 2 |
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Anatomy and Physiology of Vision: The Visual Pathways | Alfredo A. Sadun, MD, PhD | Introduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn... | Optic Nerve; Optic Disc; Retina; Retinal Ganglion Cells; Optic Chiasm; Visual Cortex; Pituitary Adenoma; Optic Atrophy; Anatomy of Visual Pathways; Afferent Visual Pathways | |
| 3 |
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Apoptosis of Retinal Ganglion Cells | Alfredo A. Sadun, MD, PhD | Presented at a conference on neuroprotection at Sedona, Arizona, 2002; includes several microscopic images demonstrating cell death. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma | |
| 4 |
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Compressive Optic Neuropathies Potpourri | Alfredo A. Sadun, MD, PhD | An overview of compressive optic neuropathies, including symptoms, varieties, testing, and treatments; slide presentation includes several neuroimaging scans. Anatomy: Optic nerve. Disease/Diagnosis: Compression of optic nerve. Treatment: Mifepristone | Optic Nerve; Compression of Optic Nerve; Mifepristone | |
| 5 |
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Distinguishing an Optic Neuropathy from a Maculopathy | Alfredo A. Sadun, MD, PhD | PPT describing a case of optic neuropathy. Covers signs and symptoms, and various laboratory tests. Describes 10 signes of disc edema. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; Afferent pupillar... | Optic Nerve Diseases; Retinal Lesion; Macular Lesion; Disorder of the Optic Nerve; Afferent Pupillary Defect; Edema; Optic Nerve; Retina; Retinal Macula; Scotoma; Optic Neuritis; Hyperopia; Metamorphopsia; Diseases of the Optic Nerve | |
| 6 |
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Distinguishing Optic Nerve vs. Retinal Lesions | Alfredo A. Sadun, MD, PhD | PPT describing methods of distinguishing optic nerve verses retinal lesions. Describes a pateint case. Discussed signs, symtpoms and diagnostic tests. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; A... | Optic Nerve Diseases; Retinal Lesion; Disorder of the Optic Nerve; Macular Lesion; Retinal Macula; Afferent Pupillary Defect; Scotoma; Optic Neuritis; Hyperopia; Metamorphopsia; Optic Nerve; Retina; Diseases of the Optic Nerve | |
| 7 |
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Engineering the Visual System | Alfredo A. Sadun, MD, PhD | Physiological basis of vision, covering perimetry, retinal ganglion cell types, and retinal pathways. Anatomy: Optic nerve; Retina. | Vision; Color Perception; Optic Nerve; Retina; Afferent Visual Pathways | |
| 8 |
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Field Investigation of a Giant Pedigree of LHON in Rural Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness, | Optic Atrophy; Hereditary; Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 9 |
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Leber's Hereditary Optic Neuropathy (LHON): New Rules of Engagement | Alfredo A. Sadun, MD, PhD | Slide presentation with several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Optic Atrophy; Hereditary; Leber; Apoptosis; Cell Death; Blindness; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species | |
| 10 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree From Brazil | Alfredo A. Sadun, MD, PhD | Four slides showing optic disc with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Optic Atrophy; Hereditary; Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 11 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON, Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Optic Atrophy; Hereditary; Leber; Blindness; Scotoma; Dyschromatopsia; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death | |
| 12 |
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Management Approach to Isolated Ocular Motor Nerve Palsies | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve; Oculomotor nerve; Trochlear nerve; Abducens nerve; Pupil. Disease/Diagnosis: Oculomotor nerve diseases; Trochlear nerve diseases; Oculomotor nerve paralysis; Fourth cranial nerve palsy; Abducens nerve diseases; Gradenigo's syndrome; Ophthalmoplegia; Temporal Arteritis; Nerve co... | Diplopia; Hypertropia; Optic Nerve; Oculomotor Nerve; Trochlear Nerve; Pupil; Oculomotor Nerve Diseases; Trochlear Nerve Diseases; Abducens Nerve; Abducens Nerve Diseases; Gradenigo's Syndrome; Ophthalmoplegia; Temporal Arteritis; Nerve Compression Syndromes | |
| 13 |
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Mitochondria and the RGC | Alfredo A. Sadun, MD, PhD | Discussion of various forms of mitrochondrial optic neuropathies and how to distinguish from toxic optic neuropathies, with examples from Cuba and Brazil. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia. Anatomy: Optic nerve; Optic disc; Retinal ganglion cells; Reactive oxyge... | Optic Nerve; Optic Disc; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Optic Atrophy; Autosomal Dominant; Optic Atrophy; Hereditary; Leber; Toxic Optic Neuropathy; Brazil; Cuba; Linezolid | |
| 14 |
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Neuro-Surgical Approaches to the Orbit | Alfredo A. Sadun, MD, PhD | Discusses specifics of various approaches to surgical treatment of lesions, including transcranial and transfrontal orbitotomies; neuroimagery scans from before and after operation for meningioma. Presenting Symptom: Proptosis. Anatomy: Orbit; Optic nerve sheath. Disease/Diagnosis: Meningioma; Heman... | Coloboma; Aplasia; Proptosis; Orbit; Optic Nerve Sheath; Meningioma; Hemangiopericytoma; Neurosurgery; Osteotomy | |
| 15 |
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Neuroprotection = Apoptosis of Retinal Ganglion Cells | Alfredo A. Sadun, MD, PhD | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Presenting Symptom: Blindness; Ischemia; Retinal detachment. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunod... | Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy; Hereditary; Leber; Acquired Immunodeficiency Syndrome | |
| 16 |
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Office Techniques for Detecting Optic Nerve Disease | Alfredo A. Sadun, MD, PhD | Demonstration of brightness sense testing and of computer-generated graphics for Amsler grid testing. Presenting Symptom: Scotoma; Metamorphopsia. Anatomy: Optic nerve; Retina; Macula lutea. Disease/Diagnosis: Glaucoma; Optic neuritis; Macular degeneration. | Color Vision; Glaucoma; Macular Degeneration; Optic Neuritis; Scotoma; Metamorphopsia; Optic Nerve; Retina; Macula Lutea | |
| 17 |
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Optic Nerve Regeneration | Alfredo A. Sadun, MD, PhD | A slide presentation with three sets of 3 views increasing magnification. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic neuropathy, Ischemic; Retrograde degeneration; Necrosis. Treatment: Cerestat; Aptiganel; Memantine; Riluzole. | Nerve Regeneration; Optic Nerve; Retina; Retrograde Degeneration; Necrosis; Apoptosis; Cell Death; Cerestat; Aptiganel; Memantine; Riluzole | |
| 18 |
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Optic Neuritis Treatment Trials | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve. Disease/Diagnosis: Optic neuritis; Multiple sclerosis. Treatment: Methylprednisolone; Prednisone; Solumedrol. | Optic Neuritis; Multiple Sclerosis; Optic Nerve; Methylprednisolone; Prednisone; Solumedrol | |
| 19 |
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Testing the Functional Patient | Alfredo A. Sadun, MD, PhD | Discusses testing to distinguish organic ailments from psychosomatic or willful simulation of symptoms. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic nerve diseases; Retinal degeneration; Hysteria | Malingering; Hysteria; Optic Nerve; Retina; Optic Nerve Diseases; Retinal Degeneration | |
| 20 |
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Visual Fields | Alfredo A. Sadun, MD, PhD | Slideshow presentation with images of bow-tie atrophy due to an optic disc tract lesion. Anatomy: Optic chiasm; Optic nerve; Optic disk. Disease/Diagnosis: Pituitary adenoma; Bitemporal hemianopia; Optic nerve atrophy. | Visual Fields; Amsler Chart; Optic Chiasm; Optic Nerve; Optic Disk; Pituitary Adenoma; Bitemporal Hemianopia; Optic Nerve Atrophy | |
| 21 |
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Viagra and Vision Loss: Does Sex Make You Blind? | Alfredo A. Sadun, MD, PhD | At a formal debate during a meeting in Canada in Sept. 2006, Sadun was assigned the role of arguing the case FOR a connection between taking phosphodiesterase 5 (PDE5) inhibitors and developing anterior ischemic optic neuropathy. Presenting Symptom: Hypotension. Anatomy: Optic nerve; Optic disc; Cyc... | Sildenafil; Vardenafil; Tadalafil; Viagra; Levitra; Cialis; Optic Neuropathy, Ischemic; Toxic Optic Neuropathy; Optic Nerve; Optic Disc; Cyclic Nucleotide Phosphodiesterases, Type 5; Hypotension | |
| 22 |
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Optical Coherence Tomography (OCT) Applications in the Eye | Alfredo A. Sadun, MD, PhD | Optical Coherence Tomography is a technique for non-invasive cross-sectional imaging of ocular tissues. This PowerPoint covers an overview of the technique with excellent diagrams and images. Anatomy: Retina; Anterior eye segment; Cornea; Macula Lutea; Vitreous body; Optic nerve; Retinal ganglion ce... | Tomography, Optical Coherence; Retina; Anterior Eye Segment; Cornea; Macula Lutea; Vitreous Body; Optic Nerve; Retinal Ganglion Cells; Retinal Diseases; Glaucoma; Macular Edema; Retinal Edema; NFLA Optical Coherence Tomography | |
| 23 |
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Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Alfredo A. Sadun, MD, PhD | Presentation at Harvard in 2006, focussing on Leber's Heriditary Optic Neuropathy; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic nerve diseases; Optic Atrophy, Hereditary, Leber. Presenting Symptom:... | Scotoma; Dyschromatopsia; Ataxia; Hyporeflexia; Optic Nerve Diseases; Optic Atrophy, Hereditary, Leber; Cuba; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death; Ethambutol | |
| 24 |
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An Epidemic of Blindness in Cuba: Lessons on Nutrition and Mitochondria | Alfredo A. Sadun, MD, PhD | Presented at Stanford in April 2007, recapping the 1990s expedition to Cuba to investigate causes of blindness epidemic. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ambliopia; Ataxia; Paresthesia; Hyporeflexia. | Cuba; Castro, Fidel; Folate; Optic Nerve; Optic Nerve Diseases; Alcoholic Neuropathy; Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia | |
| 25 |
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Optic Nerve Sheath Decompression in the Management of Optic Neuropathies | Alfredo A. Sadun, MD, PhD | A slide presentation with several images of optic disc, normal and with edema. Anatomy: Optic nerve; Optic disc. Disease/Diagnosis: Optic neuropathy, Ischemic; Pseudotumor cerebri; Papilledema. Treatment: Decompression, Surgical. | Decompression, Surgical; Optic Neuropathy, Ischemic; Pseudotumor Cerebri; Papilledema; Optic Nerve; Optic Disc |