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TitleDescriptionSubjectCollection
176 Proerythroblasts in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The two proerythroblasts (1) are large cells with condensed nuclear chromatin and a deep blue-stained basophilic cytoplasm with so-called ears (→, bulging) where ribosomes (in electron microscopy) are aggregated or shifted towards the periphery of the cell. (2) smu...Poja Histology Collection - Blood & Bone Marrow Subset
177 Promonocyte in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The promonocyte (1) has an irregular nucleus and shows the first step towards indentation (arrow). The cell has a characteristic greyish-blue cytoplasm. (2) Represents three young neutrophils. (3) A plasmacytoid lymphocyte.Poja Histology Collection - Blood & Bone Marrow Subset
178 Promonocyte in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The young promonocyte (1) shows clear nucleoli and a distinct indentation of the nucleus (arrow). (2) Neutrophilic myelocyte.Poja Histology Collection - Blood & Bone Marrow Subset
179 PromyelocyteScheme electron microscopy. The large promyelocyte (15-25 μm) contains a nucleus (1) with one or two nucleoli, the rough endoplasmic reticulum (4) is present and show many expanded profiles. Distinct also are numerous ribosomes and a well-developed Golgi area (2) where 'non-specific', primary or az...Poja Histology Collection - Blood & Bone Marrow Subset
180 Promyelocyte and basophilic erythroblast in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The composition shows a (pro)myelocyte (1) along a basophilic erythroblast (2). The (pro)myelocyte nucleus is less condensed, contains nucleoli and the light basophilic cytoplasm is filled with azurophilic granules. The cytoplasm of the erythroblast is strong basophi...Poja Histology Collection - Blood & Bone Marrow Subset
181 Promyelocyte and myelocyte in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The large promyelocyte (1) has a large nucleus with fine disperse chromatine and visible nucleoli. The cell contains primary, azurophilic granules. In the myelocyte (2) the nucleus is located eccentrically at one side of the cell, and the amount of cytoplasm is relat...Poja Histology Collection - Blood & Bone Marrow Subset
182 Promyelocyte in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The promyelocyte is the largest cell in the myeloid series in bone marrow. The nucleus is still transparent with fine chromatin and nucleoli are well visible. The cytoplasm contains ample azurophilic, primary granules.Poja Histology Collection - Blood & Bone Marrow Subset
183 Promyelocyte in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). The large promyelocyte contains nucleoli, coarse chromatin pattern, and abundant azurophilic granules in a basophilic cytoplasm. (2) A neutrophilic band form leukocyte with folded nucleus.Poja Histology Collection - Blood & Bone Marrow Subset
184 Prostatic carcinoma metastasis in bone marrow of sternum (human)Stain: Hematoxylin and eosin. Survey (A) and detail (B) of a prostate carcinoma metastasized to the bone marrow, (sternum aspiration). Clusters of tumour cells; clearly foreign to the marrow. Common primary tumours that metastasize to the bone marrow include breast, prostate, lung, thyroid, kidney, ...Poja Histology Collection - Blood & Bone Marrow Subset
185 Reactive promyelocyte during sepsis or chemotherapy in peripheral bood smear (human)Stain: May-Grnwald-Giemsa (MGG). Neutrophilic promyelocyte with toxic granulation and vacuolar degeneration. Note that nucleoli are still visible.Poja Histology Collection - Blood & Bone Marrow Subset
186 Reticulocyte (peripheral blood, human)Electron microscopy. An anucleate reticulocyte with fimbriated processes (asymmetrical folding of the cell membrane) after nuclear extrusion. The cytoplasm contains a heavy amount of hemoglobin, electron-dense lysosomes, vesicular remnants as well as scattered clumped polysomes.Poja Histology Collection - Blood & Bone Marrow Subset
187 Reticulocytes in peripheral blood smear (human)Stain: Brilliant cresyl blue. The blue stained reticulum strands and aggregates (1) are ribosomal residues in the young red blood cells that just have expelled their nuclei. The reticulocytes are not to be confused with large Heinz bodies. Heinz bodies (↓, arrows) are red cell inclusions composed ...Poja Histology Collection - Blood & Bone Marrow Subset
188 Reticulocytes in peripheral blood smear (human)Stain: Brilliant cresyl blue. After expulsion of the erythroblastic nucleus the remaining cell is called reticulocyte. This staining visualizes the remained aggregated strands of polysomes as a fine network. The expulsed nucleus will be phagocytosed by macrophages and reticular cells in the bone mar...Poja Histology Collection - Blood & Bone Marrow Subset
189 Reticulocytosis in peripheral blood smear (human)Stain: May-Grnwald-Giemsa (MGG). The slightly pale blue stained cells (1) represent the reticulocytes. These young red blood cells are stained bluish because of the presence of ribosomal RNA.Poja Histology Collection - Blood & Bone Marrow Subset
190 Shift to the left response of granulocytes in blood smear (human)Stain: May-Grnwald-Giemsa (MGG). During infection a shift towards a relative increase of the number of neutrophilic granulocytes (3) with reduced lobulation of the nuclei and immature white cells, occurs in blood. (1) promonocyte. (2) (pro)myelocyte.Poja Histology Collection - Blood & Bone Marrow Subset
191 Skull TutorialThis tutorial module consists of a series of digitized images of the skull, illustrating bones, foramina, bony landmarks, and protuberances which were converted into Macromedia Flash for online distribution. The objective for creating the courseware was to stimulate more active self-directed learnin...OsteologyHEAL Reviewed Collection
192 Small, medium and large lymphocytes in blood smear (human)Stain: May-Grnwald-Giemsa (MGG). The picture shows three activation stages of lymphocytes as (1) small, (2) medium and (3) large lymphocytes. In that range the nucleus becomes less condensed and more transparent, while the amount of cytoplasm increases. The large lymphocyte also contains some granul...Poja Histology Collection - Blood & Bone Marrow Subset
193 Survey and detail of a peripheral blood smear contaminated with endothelial cells (human)Stain: May-Grnwald-Giemsa (MGG). Survey (A) and details (B) show aggregates of elongated cells with a large nucleus, mostly situated at the end of a smear between the erythrocytes and granulocytes. These endothelial cells are contaminants derived from blood vessels during puncture.Poja Histology Collection - Blood & Bone Marrow Subset
194 Survey and detail of bone marrow section (human)Stain: modified hematoxylin and eosin (A, B). The bone marrow consists of bone trabecles or crests (1) covered with osteoclasts and osteoblasts. Between the trabecles bone marrow parenchym (2) consisting of progenitor cells, reticular cells and fat cells (3). Numerous capillaries (B, 4) and enlarged...Poja Histology Collection - Blood & Bone Marrow Subset
195 Survey of bone marrow (bone marrow, rabbit)Electron microscopy. Within the loose reticular tissue a great variety of different stages of young erythrocytes (3, 4) as well as of young granulocytes (5) is present. (2) indicates reticular cells and (2b) phagocytizing reticular cells. (1) fat cells (adipocytes); (6) myeloid cell; (7) capillary.Poja Histology Collection - Blood & Bone Marrow Subset
196 Survey of bone marrow section (human)Stain: modified hematoxylin and eosin. In this survey the white spots (1) are fat cells. The marrow is well filled with cells of erythropoietic and myelopoietic series. The very large cells are usually megakaryocytes. Cells with very dark condensed nuclei belong mostly to the erythropoietic series.Poja Histology Collection - Blood & Bone Marrow Subset
197 Survey of megakaryocytes (peripheral blood, human)Electron microscopy. In a section of a so-called buffy coat collected from peripheral blood two huge polyploid megakaryocytes (1) (diameter up to 160 μm) are present. Note the dark granules in the future platelets. (2) erythroblasts; (3) reticulocytes and erythrocytes; (4, 5) monocytes. The arrows ...Poja Histology Collection - Blood & Bone Marrow Subset
198 testingtesttestPeer Review Pending
199 Three basophilic erythroblasts in bone marrow smear (human)Stain: May-Grnwald-Giemsa (MGG). Three basophilic erythroblasts (1) with intense blue stained cytoplasm, and some so called ears or cytoplasmic projections (arrows). Chromatin strands are thicker than in the proerythroblast. Generally no nucleoli are seen. (2) Damaged or smudged eosinophilic myelocy...Poja Histology Collection - Blood & Bone Marrow Subset
200 Toxic granulation and vacuolation in neutrophilic myelocytes in peripheral blood smear (human)Stain: May-Grnwald-Giemsa (MGG). The myelocyte (1) and the metamyelocyte (2) show toxic granulation and vacuolation and cytoplasmic swelling. Vacuoles may represent the terminal stage of autophagocytosis. Granules may burst and their contents undergo autophagocytosis in a number of pathologic condit...Poja Histology Collection - Blood & Bone Marrow Subset
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