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Title | Creator | Description | Subject | Imaging |
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Optical Coherence Tomography (OCT) Applications in the Eye | Alfredo A. Sadun, MD, PhD | Optical Coherence Tomography is a technique for non-invasive cross-sectional imaging of ocular tissues. This PowerPoint covers an overview of the technique with excellent diagrams and images. Anatomy: Retina; Anterior eye segment; Cornea; Macula Lutea; Vitreous body; Optic nerve; Retinal ganglion ce... | Tomography, Optical Coherence; Retina; Anterior Eye Segment; Cornea; Macula Lutea; Vitreous Body; Optic Nerve; Retinal Ganglion Cells; Retinal Diseases; Glaucoma; Macular Edema; Retinal Edema; NFLA Optical Coherence Tomography | |
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Anatomy and Physiology of the Optic Nerve | Alfredo A. Sadun, MD, PhD | Lecture covering the anatomy and physiology of the optic nerve. Covers the retina and anterior visual pathways. Several slides show microscopic images of optic nerve damage. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma; Anatomy of the Optic Nerve; AVP Optic Nerve | |
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Toxic Optic Neuropathies: Mitochondria and the RGC | Alfredo A. Sadun, MD, PhD | Discussion of various forms of mitrochondrial optic neuropathies and how to distinguish from toxic optic neuropathies, with examples from Cuba and Brazil; includes images of optic disc showing LHON. Presenting Symptom: Blindness; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia. Anatomy: Optic ne... | Optic Nerve; Optic Disc; Retinal Ganglion Cells; Reactive Oxygen Species; Blindness; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Optic Atrophy, Autosomal Dominant; Optic Atrophy, Hereditary, Leber; Toxic Optic Neuropathy; Alcoholic Neuropathy; Brazil; Cuba; Linezolid; Ethambutol; Tomography... | |
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How Mitochondria Orchestrate the Death of RGCs : From Brazil to Tuebingen to Rochester 2007 | Alfredo A. Sadun, MD, PhD | Slides showing LHON and Kjer's optic atrophy and images of optic disk with LHON. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Blindness. | Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Apoptosis; Cell Death; Dyschromatopsia; Blindness; Optic Atrophy; Hereditary; Leber; Leber's Optic Neuropathy | |
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Anatomy and Physiology of Vision: The Visual Pathways | Alfredo A. Sadun, MD, PhD | Introduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn... | Optic Nerve; Optic Disc; Retina; Retinal Ganglion Cells; Optic Chiasm; Visual Cortex; Pituitary Adenoma; Optic Atrophy; Anatomy of Visual Pathways; Afferent Visual Pathways | |
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Apoptosis of Retinal Ganglion Cells | Alfredo A. Sadun, MD, PhD | Presented at a conference on neuroprotection at Sedona, Arizona, 2002; includes several microscopic images demonstrating cell death. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma | |
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Circadian Rhythms: How Much Retina Do We Need for a Good Night's Sleep? | Alfredo A. Sadun, MD, PhD | Discusses importance of the health of the retinohypothalamic tract in the maintenance of circadian rhythm. Anatomy: Retina; Hypothalamus; Retinal ganglion cells; Pineal gland. Disease/Diagnosis: Retinal diseases; Sleep disorders, Circadian rhythm. | Circadian Rhythm; Mole Rats; Retinal Diseases; Sleep Disorders; Retina; Hypothalamus; Retinal Ganglion Cells; Pineal Gland | |
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Leber's Hereditary Optic Neuropathy (LHON): New Rules of Engagement | Alfredo A. Sadun, MD, PhD | Slide presentation with several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Optic Atrophy; Hereditary; Leber; Apoptosis; Cell Death; Blindness; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species | |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON, Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Optic Atrophy; Hereditary; Leber; Blindness; Scotoma; Dyschromatopsia; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death | |
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Mitochondria and the RGC | Alfredo A. Sadun, MD, PhD | Discussion of various forms of mitrochondrial optic neuropathies and how to distinguish from toxic optic neuropathies, with examples from Cuba and Brazil. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia. Anatomy: Optic nerve; Optic disc; Retinal ganglion cells; Reactive oxyge... | Optic Nerve; Optic Disc; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Optic Atrophy; Autosomal Dominant; Optic Atrophy; Hereditary; Leber; Toxic Optic Neuropathy; Brazil; Cuba; Linezolid | |
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Neuroprotection = Apoptosis of Retinal Ganglion Cells | Alfredo A. Sadun, MD, PhD | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Presenting Symptom: Blindness; Ischemia; Retinal detachment. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunod... | Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy; Hereditary; Leber; Acquired Immunodeficiency Syndrome | |
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Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Alfredo A. Sadun, MD, PhD | Presentation at Harvard in 2006, focussing on Leber's Heriditary Optic Neuropathy; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic nerve diseases; Optic Atrophy, Hereditary, Leber. Presenting Symptom:... | Scotoma; Dyschromatopsia; Ataxia; Hyporeflexia; Optic Nerve Diseases; Optic Atrophy, Hereditary, Leber; Cuba; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death; Ethambutol | |
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Leber's Hereditary Optic Neuropathy: New Lessons From a Giant Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Optic Atrophy, Hereditary, Leber; Blindness; Papilledema; Scotoma; Dyschromatopsia; Optic Nerve; Optic Disc; Retinal Ganglion Cells; Brazil; Apoptosis; Cell Death | |
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Apoptosis in LHON: An ROS Explanation | Alfredo A. Sadun, MD, PhD | A slide presentation describing apoptosis in LHON; includes several images of optic nerve and optic disk. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Optic Atrophy, Hereditary, Leber; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Apoptosis; Cell Death; ROS1 Protein, Human | |
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Subclinical Visual Abnormalities in Carriers With 11778 LHON from a 300 Member Brazilian Pedigree | Alfredo A. Sadun, MD, PhD | Report of a multi-year international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presenting Symptom: Scotoma; Telangiectasis; Blindness. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Pathology: Slides showing LHON ... | Optic Atrophy, Hereditary, Leber; Optic Atrophy, Autosomal Dominant; Optic Nerve; Optic Disk; Myelin Sheath; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Blindness; Brazil | |
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Mitochondrial Optic Neuropathies (MON) | Alfredo A. Sadun, MD, PhD | Combination of two presentations on optic nerve diseases, covering the cases in Cuba and Brazil. Titles: Cuban epidemic of optic neuopathy: even zealots must eat, or, Conversations with Castro and Leber's hereditary optic neuropathy: a very large new pedigree in Brazil; includes several images of ... | Optic Nerve Diseases; Optic Atrophy, Hereditary, Leber; Blindness; Alcoholic Neuropathy; Cuba; Castro, Fidel; Folate; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death | |
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Beyond the Margulis Hypothesis: The Time Bomb Within Us | Alfredo A. Sadun, MD, PhD | Presented at Harvard, 2005; includes several images of optic disc with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Dyschromatopsia; Scotoma. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Dyschromatopsia; Scotoma | |
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Beyond the Margulis Hypothesis: The Time Bomb Within Us | Alfredo A. Sadun, MD, PhD | Presented at 36th Annual Doheny Days, 2005. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species | |
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A Neuro-Ophthalmologist's View of RGC Apoptosis and Neuroprotection | Alfredo A. Sadun, MD, PhD | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma. Presen... | Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma | |
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Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Scotoma; Dyschromatopsia. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Toxic Optic Neuropathy; Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species; Amiodarone; Scotoma; Dyschromatopsia | |