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Identification of OPA1 Mutations in Autosomal Dominant Optic Atrophy (ADOA): Toward the Role of the Mitochondria in ADOA | Michael D. Brown, PhD; Jian Han, PhD; Alyson Reiss, BS; Valerie Biousse, MD; Nancy J. Newman, MD | Mutations in the OPA1 gene product result in the most common form of autosomal dominant optic atrophy (ADOA).The OPA gene product has been localized to the mitochondria and OPA1 mutations disrupt the normal mitochondrial network within cells, leading to perinuclear clustering of the mitochondria. | 20040331_nanos_posters_061 |