The Alfredo A. Sadun Neuro-Ophthalmology Collection: A Professor of Ophthalmology and Neurological Surgery at the USC Keck School of Medicine, Dr. Sadun with a team of researchers at the Doheny Eye Institute pioneered research in optic nerve dysfunction in patients with Alzheimer's disease. Contains his "100 best lectures." Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor Ophthalmology & Neurological Surgery, Doheny Eye Institute, Keck School of Medicine at USC.
NOVEL: https://novel.utah.edu/
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| Title | Creator | Description | Subject | Imaging | ||
|---|---|---|---|---|---|---|
| 1 |
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Induction of Apoptosis by Mitochondrial Impairment in LHON and Related Diseases | Alfredo A. Sadun, MD, PhD | Slide presentation includes six pairs of microscopic slides showing LHON and control examples of optic nerve. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Optic Atrophy, Hereditary, Leber; Apoptosis; Cell Death | |
| 2 |
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Leber's Hereditary Optic Neuropathy: New Insights? | Alfredo A. Sadun, MD, PhD | Several microscopic images of optic nerve with LHON. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Scotoma; Dyschromatopsia. | Optic Atrophy, Hereditary, Leber; Optic nerve; Scotoma; Dyschromatopsia | |
| 3 |
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Extremely High Resolution Magnetic Resonance Imaging of the Human Optic Nerve Head | Alfredo A. Sadun, MD, PhD | MRI imagery of optic nerves demonstrates ability to identify cases of Leber's Hereditary Optic Neuropathy (LHON); includes MRI images of optic nerves. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Optic Nerve; Optic Atrophy, Hereditary, Leber; Magnetic Resonance Imaging | |
| 4 |
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Field Investigation of a Giant Pedigree of LHON in Rural Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness, | Optic Atrophy; Hereditary; Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 5 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree From Brazil | Alfredo A. Sadun, MD, PhD | Four slides showing optic disc with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Optic Atrophy; Hereditary; Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 6 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindnes... | Optic Atrophy, Hereditary, Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 7 |
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Subclinical Visual Abnormalities in Carriers With 11778 LHON from a 300 Member Brazilian Pedigree | Alfredo A. Sadun, MD, PhD | Report of a multi-year international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presenting Symptom: Scotoma; Telangiectasis; Blindness. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Pathology: Slides showing LHON ... | Optic Atrophy, Hereditary, Leber; Optic Atrophy, Autosomal Dominant; Optic Nerve; Optic Disk; Myelin Sheath; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Blindness; Brazil | |
| 8 |
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Mitochondria and the RGC | Alfredo A. Sadun, MD, PhD | Discussion of various forms of mitrochondrial optic neuropathies and how to distinguish from toxic optic neuropathies, with examples from Cuba and Brazil. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia. Anatomy: Optic nerve; Optic disc; Retinal ganglion cells; Reactive oxyge... | Optic Nerve; Optic Disc; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Optic Atrophy; Autosomal Dominant; Optic Atrophy; Hereditary; Leber; Toxic Optic Neuropathy; Brazil; Cuba; Linezolid | |
| 9 |
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Beyond the Margulis Hypothesis: The Time Bomb Within Us | Alfredo A. Sadun, MD, PhD | Presented at 36th Annual Doheny Days, 2005. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species | |
| 10 |
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Toxic Optic Neuropathies: Mitochondria and the RGC | Alfredo A. Sadun, MD, PhD | Discussion of various forms of mitrochondrial optic neuropathies and how to distinguish from toxic optic neuropathies, with examples from Cuba and Brazil; includes images of optic disc showing LHON. Presenting Symptom: Blindness; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia. Anatomy: Optic ne... | Optic Nerve; Optic Disc; Retinal Ganglion Cells; Reactive Oxygen Species; Blindness; Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Optic Atrophy, Autosomal Dominant; Optic Atrophy, Hereditary, Leber; Toxic Optic Neuropathy; Alcoholic Neuropathy; Brazil; Cuba; Linezolid; Ethambutol; Tomography... | |
| 11 |
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Leber's Hereditary Optic Neuropathy (LHON) in Brazil: Opportunities | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic roots. Presented at Allergan, 2006. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Myelin sheath; Optic Disk. Disease/Diagnosis: Optic Atrophy, H... | Optic Atrophy, Hereditary, Leber; Optic Nerve; Optic Disk; Myelin Sheath; Brimonidine; Alphagan; Edema; Scotoma; Telangiectasis; Blindness; Brazil | |
| 12 |
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Jonathan D. Wirtschafter, MD, FACS, Frank E. Burch Professor of Ophthalmology | Alfredo A. Sadun, MD, PhD | Overview of the life of Jonathan D. Wirtschafter on the occasion of the first annual Wirtschafter Lectureship, in August of 2003. Sadun gave the lecture, recapping an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images o... | Optic Atrophy, Hereditary, Leber; Blindness; Scotoma; Dyschromatopsia; Brazil; Optic Nerve; Optic Disk; Apoptosis; Cell Death; Wirtschafer, Jonathan D. | |
| 13 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON, Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Optic Atrophy; Hereditary; Leber; Blindness; Scotoma; Dyschromatopsia; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death | |
| 14 |
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Beyond the Margulis Hypothesis: The Time Bomb Within Us | Alfredo A. Sadun, MD, PhD | Presented at Harvard, 2005; includes several images of optic disc with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Dyschromatopsia; Scotoma. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Dyschromatopsia; Scotoma | |
| 15 |
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Leber's Hereditary Optic Neuropathy (LHON): New Rules of Engagement | Alfredo A. Sadun, MD, PhD | Slide presentation with several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Optic Atrophy; Hereditary; Leber; Apoptosis; Cell Death; Blindness; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species | |
| 16 |
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Leber's Hereditary Optic Neuropathy: New Lessons From a Giant Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Pres... | Optic Atrophy, Hereditary, Leber; Blindness; Papilledema; Scotoma; Dyschromatopsia; Optic Nerve; Optic Disc; Retinal Ganglion Cells; Brazil; Apoptosis; Cell Death | |
| 17 |
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The Diagnostic Workup in Patients With Optic Neuropathies | Alfredo A. Sadun, MD, PhD | Slideshow presentation with images of optic disc with edema and optic atrophy. Presenting Symptom: Telangiectasis; Dyschromatopsia; Scotoma. Anatomy: Optic nerve; Optic disc; Phosphopyruvate Hydratase; Enolase. Disease/Diagnosis: Optic neuritis; Macular edema; Optic neuropathy, Ischemic; Optic atrop... | Telangiectasis; Dyschromatopsia; Scotoma; Optic Nerve; Optic Disc; Phosphopyruvate Hydratase; Enolase; Optic Neuritis; Macular Edema; Optic Neuropathy, Ischemic; Optic Atrophy, Hereditary | |
| 18 |
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Apoptosis in LHON: An ROS Explanation | Alfredo A. Sadun, MD, PhD | A slide presentation describing apoptosis in LHON; includes several images of optic nerve and optic disk. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Optic Atrophy, Hereditary, Leber; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Reactive Oxygen Species; Apoptosis; Cell Death; ROS1 Protein, Human | |
| 19 |
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Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Scotoma; Dyschromatopsia. | Apoptosis; Cell Death; Optic Atrophy, Hereditary, Leber; Toxic Optic Neuropathy; Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species; Amiodarone; Scotoma; Dyschromatopsia | |
| 20 |
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Neuroprotection = Apoptosis of Retinal Ganglion Cells | Alfredo A. Sadun, MD, PhD | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Presenting Symptom: Blindness; Ischemia; Retinal detachment. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunod... | Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy; Hereditary; Leber; Acquired Immunodeficiency Syndrome | |
| 21 |
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A Neuro-Ophthalmologist's View of RGC Apoptosis and Neuroprotection | Alfredo A. Sadun, MD, PhD | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma. Presen... | Optic Nerve; Retina; Retinal Ganglion Cells; Phosphopyruvate Hydratase; Apoptosis; Cell Death; Blindness; Ischemia; Retinal Detachment; Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma | |
| 22 |
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Anatomy and Physiology of Vision: The Visual Pathways | Alfredo A. Sadun, MD, PhD | Introduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn... | Optic Nerve; Optic Disc; Retina; Retinal Ganglion Cells; Optic Chiasm; Visual Cortex; Pituitary Adenoma; Optic Atrophy; Anatomy of Visual Pathways; Afferent Visual Pathways | |
| 23 |
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How Mitochondria Orchestrate the Death of RGCs : From Brazil to Tuebingen to Rochester 2007 | Alfredo A. Sadun, MD, PhD | Slides showing LHON and Kjer's optic atrophy and images of optic disk with LHON. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Blindness. | Optic Nerve; Retina; Retinal Ganglion Cells; Reactive Oxygen Species; Scotoma; Telangiectasis; Apoptosis; Cell Death; Dyschromatopsia; Blindness; Optic Atrophy; Hereditary; Leber; Leber's Optic Neuropathy | |
| 24 |
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Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Alfredo A. Sadun, MD, PhD | Presentation at Harvard in 2006, focussing on Leber's Heriditary Optic Neuropathy; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic nerve diseases; Optic Atrophy, Hereditary, Leber. Presenting Symptom:... | Scotoma; Dyschromatopsia; Ataxia; Hyporeflexia; Optic Nerve Diseases; Optic Atrophy, Hereditary, Leber; Cuba; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death; Ethambutol | |
| 25 |
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Mitochondrial Optic Neuropathies (MON) | Alfredo A. Sadun, MD, PhD | Combination of two presentations on optic nerve diseases, covering the cases in Cuba and Brazil. Titles: Cuban epidemic of optic neuopathy: even zealots must eat, or, Conversations with Castro and Leber's hereditary optic neuropathy: a very large new pedigree in Brazil; includes several images of ... | Optic Nerve Diseases; Optic Atrophy, Hereditary, Leber; Blindness; Alcoholic Neuropathy; Cuba; Castro, Fidel; Folate; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death |