The Alfredo A. Sadun Neuro-Ophthalmology Collection: A Professor of Ophthalmology and Neurological Surgery at the USC Keck School of Medicine, Dr. Sadun with a team of researchers at the Doheny Eye Institute pioneered research in optic nerve dysfunction in patients with Alzheimer's disease. Contains his "100 best lectures." Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor Ophthalmology & Neurological Surgery, Doheny Eye Institute, Keck School of Medicine at USC.
NOVEL: https://novel.utah.edu/
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| Title | Creator | Description | Subject | Imaging | ||
|---|---|---|---|---|---|---|
| 1 |
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Compressive Optic Neuropathies Potpourri | Alfredo A. Sadun, MD, PhD | An overview of compressive optic neuropathies, including symptoms, varieties, testing, and treatments; slide presentation includes several neuroimaging scans. Anatomy: Optic nerve. Disease/Diagnosis: Compression of optic nerve. Treatment: Mifepristone | Optic Nerve; Compression of Optic Nerve; Mifepristone | |
| 2 |
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Testing the Functional Patient | Alfredo A. Sadun, MD, PhD | Discusses testing to distinguish organic ailments from psychosomatic or willful simulation of symptoms. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic nerve diseases; Retinal degeneration; Hysteria | Malingering; Hysteria; Optic Nerve; Retina; Optic Nerve Diseases; Retinal Degeneration | |
| 3 |
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Optic Nerve Tumors: Diagnosis and Therapy | Alfredo A. Sadun, MD, PhD | Powerppoint lecture covers a patient case, differential diagnosis, and optic nerve anatomy. Also includes examination information, fundus images and visual field defects. Presenting Symptom: Proptosis; Hemianopsia; Scotoma. Anatomy: Optic nerve; Structure of pituitary fossa; Optic nerve sheath. Dise... | Optic Nerve; Structure of Pituitary Fossa; Optic Nerve Sheath; Proptosis; Hemianopsia; Scotoma; Optic Nerve Neoplasms; Meningioma; Optic Nerve Glioma; Chiasmal Visual Field Defects | |
| 4 |
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Anatomy and Physiology of the Optic Nerve | Alfredo A. Sadun, MD, PhD | Lecture covering the anatomy and physiology of the optic nerve. Covers the retina and anterior visual pathways. Several slides show microscopic images of optic nerve damage. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma; Anatomy of the Optic Nerve; AVP Optic Nerve | |
| 5 |
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Distinguishing Optic Nerve vs. Retinal Lesions | Alfredo A. Sadun, MD, PhD | PPT describing methods of distinguishing optic nerve verses retinal lesions. Describes a pateint case. Discussed signs, symtpoms and diagnostic tests. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; A... | Optic Nerve Diseases; Retinal Lesion; Disorder of the Optic Nerve; Macular Lesion; Retinal Macula; Afferent Pupillary Defect; Scotoma; Optic Neuritis; Hyperopia; Metamorphopsia; Optic Nerve; Retina; Diseases of the Optic Nerve | |
| 6 |
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Distinguishing an Optic Neuropathy from a Maculopathy | Alfredo A. Sadun, MD, PhD | PPT describing a case of optic neuropathy. Covers signs and symptoms, and various laboratory tests. Describes 10 signes of disc edema. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; Afferent pupillar... | Optic Nerve Diseases; Retinal Lesion; Macular Lesion; Disorder of the Optic Nerve; Afferent Pupillary Defect; Edema; Optic Nerve; Retina; Retinal Macula; Scotoma; Optic Neuritis; Hyperopia; Metamorphopsia; Diseases of the Optic Nerve | |
| 7 |
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An Epidemic of Blindness in Cuba: Lessons on Nutrition and Mitochondria | Alfredo A. Sadun, MD, PhD | Presented at Stanford in April 2007, recapping the 1990s expedition to Cuba to investigate causes of blindness epidemic. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ambliopia; Ataxia; Paresthesia; Hyporeflexia. | Cuba; Castro, Fidel; Folate; Optic Nerve; Optic Nerve Diseases; Alcoholic Neuropathy; Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia | |
| 8 |
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Cuban Epidemic of Optic Neuropathy: Even Zealots Must Eat, or, Conversations with Castro | Alfredo A. Sadun, MD, PhD | A team of neuro-opthalmologists visits Cuba in 1993 and 1994, and attempts to treat patients with vision disorders. Anatomy: Optic nerve. Disease/Diagnosis: Optic nerve diseases; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia. | Cuba; Castro, Fidel; Folate; Optic Nerve; Optic Nerve Diseases; Blindness; Ambliopia; Alcoholic Neuropathy; Ataxia; Paresthesia; Hyporeflexia | |
| 9 |
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Visual Fields | Alfredo A. Sadun, MD, PhD | Slideshow presentation with images of bow-tie atrophy due to an optic disc tract lesion. Anatomy: Optic chiasm; Optic nerve; Optic disk. Disease/Diagnosis: Pituitary adenoma; Bitemporal hemianopia; Optic nerve atrophy. | Visual Fields; Amsler Chart; Optic Chiasm; Optic Nerve; Optic Disk; Pituitary Adenoma; Bitemporal Hemianopia; Optic Nerve Atrophy | |
| 10 |
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Leber's Hereditary Optic Neuropathy: New Insights? | Alfredo A. Sadun, MD, PhD | Several microscopic images of optic nerve with LHON. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Scotoma; Dyschromatopsia. | Optic Atrophy, Hereditary, Leber; Optic nerve; Scotoma; Dyschromatopsia | |
| 11 |
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Cuban Epidemic of Optic Neuropathy: Even Zealots Must Eat, or, Conversations with Castro | Alfredo A. Sadun, MD, PhD | A team of neuro-opthalmologists visits Cuba in 1993 and 1994, and attempts to treat patients with vision disorders. Anatomy: Optic nerve; Structure of cribriform plate. Disease/Diagnosis: Optic nerve diseases; Blindness; Ambliopia; Alcoholic neuropathy. Treatment: Folate. Presenting Symptom: Ataxia;... | Cuba; Castro, Fidel; Folate; Optic Nerve; Structure of Cribriform Plate; Optic Nerve Diseases; Alcoholic Neuropathy; Blindness; Ambliopia; Ataxia; Paresthesia; Hyporeflexia | |
| 12 |
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Engineering the Visual System | Alfredo A. Sadun, MD, PhD | Physiological basis of vision, covering perimetry, retinal ganglion cell types, and retinal pathways. Anatomy: Optic nerve; Retina. | Vision; Color Perception; Optic Nerve; Retina; Afferent Visual Pathways | |
| 13 |
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Extremely High Resolution Magnetic Resonance Imaging of the Human Optic Nerve Head | Alfredo A. Sadun, MD, PhD | MRI imagery of optic nerves demonstrates ability to identify cases of Leber's Hereditary Optic Neuropathy (LHON); includes MRI images of optic nerves. Anatomy: Optic nerve. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Optic Nerve; Optic Atrophy, Hereditary, Leber; Magnetic Resonance Imaging | |
| 14 |
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Optic Neuritis Treatment Trials | Alfredo A. Sadun, MD, PhD | Anatomy: Optic nerve. Disease/Diagnosis: Optic neuritis; Multiple sclerosis. Treatment: Methylprednisolone; Prednisone; Solumedrol. | Optic Neuritis; Multiple Sclerosis; Optic Nerve; Methylprednisolone; Prednisone; Solumedrol | |
| 15 |
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Prognosis for Vision in Idiopathic Intracranial Hypertension (IIH) | Alfredo A. Sadun, MD, PhD | Treatment options for Pseudotumor cerebri and Papilledema; includes images of optic disc with edema. Presenting Symptom: Scotoma. Anatomy: Optic disc; Optic nerve. Pathology: Microscopic view of papilledema. Disease/Diagnosis: Pseudotumor cerebri; Papilledema. Treatment: Acetazolamide; Ventriculoper... | Optic Nerve; Optic Disc; Pseudotumor Cerebri; Papilledema; Scotoma; Acetazolamide; Ventriculoperitoneal Shunt; Lumbo-Peritoneal CSF Shunt; Decompression of Optic Nerve; Raised Intracranial Pressure | |
| 16 |
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Field Investigation of a Giant Pedigree of LHON in Rural Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness, | Optic Atrophy; Hereditary; Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 17 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree From Brazil | Alfredo A. Sadun, MD, PhD | Four slides showing optic disc with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindness. | Optic Atrophy; Hereditary; Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 18 |
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Leber's Hereditary Optic Neuropathy: A Very Large New Pedigree in Brazil | Alfredo A. Sadun, MD, PhD | Report of an international field investigation to rural Brazil to study a cluster of LHON, including its genetic basis. Includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Blindnes... | Optic Atrophy, Hereditary, Leber; Blindness; Brazil; Optic Nerve; Optic Disc | |
| 19 |
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Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Alfredo A. Sadun, MD, PhD | Presentation at Harvard in 2006, focussing on Leber's Heriditary Optic Neuropathy; includes several images of optic nerve and optic disk with LHON. Anatomy: Optic nerve; Optic disk; Retinal ganglion cells. Disease/Diagnosis: Optic nerve diseases; Optic Atrophy, Hereditary, Leber. Presenting Symptom:... | Scotoma; Dyschromatopsia; Ataxia; Hyporeflexia; Optic Nerve Diseases; Optic Atrophy, Hereditary, Leber; Cuba; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death; Ethambutol | |
| 20 |
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Cushing and Ophthalmology | Alfredo A. Sadun, MD, PhD | From a lecture at Yale in 2006, reviewing the life of Harvey Cushing, the founder of neurosurgery. Anatomy: Optic chiasm; Optic nerve. Disease/Diagnosis: Pituitary adenoma; Papilledema; X-linked hydrocephalus syndrome; Optic nerve glioma; Graves ophthalmopathy; Mucocele; Pituitary apoplexy; Optic ne... | Cushing, Harvey, 1869-1939; Neurosurgery; Optic Chiasm; Optic Nerve; Proptosis; Diplopia; Ptosis; Hemianopsia; Pituitary Adenoma; Papilledema; X-linked Hydrocephalus Syndrome; Optic Nerve Glioma; Graves Ophthalmopathy; Mucocele; Pituitary Apoplexy; Optic Nerve Atrophy; Neurosurgery; Decompression, S... | |
| 21 |
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Apoptosis of Retinal Ganglion Cells | Alfredo A. Sadun, MD, PhD | Presented at a conference on neuroprotection at Sedona, Arizona, 2002; includes several microscopic images demonstrating cell death. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Optic Nerve; Retina; Retinal Ganglion Cells; Cytokines; Apoptosis; Cell Death; Glaucoma | |
| 22 |
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Neuro-Surgical Approaches to the Orbit | Alfredo A. Sadun, MD, PhD | Discusses specifics of various approaches to surgical treatment of lesions, including transcranial and transfrontal orbitotomies; neuroimagery scans from before and after operation for meningioma. Presenting Symptom: Proptosis. Anatomy: Orbit; Optic nerve sheath. Disease/Diagnosis: Meningioma; Heman... | Coloboma; Aplasia; Proptosis; Orbit; Optic Nerve Sheath; Meningioma; Hemangiopericytoma; Neurosurgery; Osteotomy | |
| 23 |
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Mitochondrial Optic Neuropathies (MON) | Alfredo A. Sadun, MD, PhD | Combination of two presentations on optic nerve diseases, covering the cases in Cuba and Brazil. Titles: Cuban epidemic of optic neuopathy: even zealots must eat, or, Conversations with Castro and Leber's hereditary optic neuropathy: a very large new pedigree in Brazil; includes several images of ... | Optic Nerve Diseases; Optic Atrophy, Hereditary, Leber; Blindness; Alcoholic Neuropathy; Cuba; Castro, Fidel; Folate; Brazil; Optic Nerve; Optic Disk; Retinal Ganglion Cells; Apoptosis; Cell Death | |
| 24 |
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Optic Nerve Sheath Decompression in the Management of Optic Neuropathies | Alfredo A. Sadun, MD, PhD | A slide presentation with several images of optic disc, normal and with edema. Anatomy: Optic nerve; Optic disc. Disease/Diagnosis: Optic neuropathy, Ischemic; Pseudotumor cerebri; Papilledema. Treatment: Decompression, Surgical. | Decompression, Surgical; Optic Neuropathy, Ischemic; Pseudotumor Cerebri; Papilledema; Optic Nerve; Optic Disc | |
| 25 |
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Acute Retrobulbar Optical Neuropathy | Alfredo A. Sadun, MD, PhD | PPT covering acute retrobulbar optic neuropathy, including ischemic, inflammatory, anterior ischemic optic neuropathy (AION) and non-arteritic anterior ischemic optic neuropathy (NAION); includes brainscan images for optic neuritis and multiple sclerosis; optic disk with LHON and PION. Anatomy: Opt... | Optic Neuropathy, Ischemic; Giant Cell Arteritis; Edema; Multiple Sclerosis; Optic Atrophy, Hereditary, Leber; Ischemia; Hypotension; Edema; Optic Neuritis; Optic Nerve; Interferon-Beta-1a; Diseases of the Optic Nerve |