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151 Ocular Myasthenia Gravis - How Effective Is Low Dose Prednisone Long Term?Ocular myasthenia gravis (OMG) therapy should address three issues - restoration of normal binocular vision. prevention of deterioration to generalize MG (GMG), and avoiding significant adverse effects of treatment. Prior studies suggest that moderate dose followed by low dose daily prednisone can a...Myasthenia, Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Ocular MotilityNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
152 Treatment Outcome in Ocular Myasthenia GravisOcular Myasthenia Gravis (OMG) is an autoimmune disease that affects the neuro-muscular junction resulting in ptosis and/or diplopia without general or bulbar symptoms. OMG patients can suffer from disabling ocular symptoms. The outcome of treatment with OMG is poorly understood. Our aim is to asse...Myasthenia, Ocular Motility, Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Diagnostic Tests (ERG, VER, OCT, HRT, mfERG, etc), Eyelid & Adnexal Disease, Adult Strabismus with a Focus on DiplopiaNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
153 Horizontal Diplopia and Left Side Cranial Nerve PalsiesAbducens Nerve Diseases; Facial Nerve Diseases; Ophthalmoplegia; Diplopia; Blepharoptosis; Pupil Disorders; Myasthenia GravisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
154 Mycophenolate Mofetil as First-Line Therapy for Ocular Myasthenia GravisOcular myasthenia gravis (OMG) may produce debilitating diplopia or ptosis leading to significant visual disability. Symptomatic treatment with pyridostigmine is frequently ineffective and immunosuppressive therapy with corticosteroids can have serious side-effects.Myasthenia; MycophenolateNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
155 Pediatric Neuromuscular Disorders (Slides)Disruption of the neuromuscular transmission, either at the presynaptic or postsynaptic junction, may result in fatigability and muscle weakness that commonly affect ocular motility and lid movement. We will review several of the pediatric disorders that influence neuromuscular transmission.Pediatric Myasthenia Gravis; Congenital Myasthenia Gravis; BotulismNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
156 Safety of Prednisone for Ocular Myasthenia GravisTreatment with chronic corticosteroids has been associated with frequent significant adverse effects. We hypothesized that the major side effect profile of a long-term, low-dose prednisone regimen for OMG was low.ocular myasthenia gravis; prednisone; clinical trials; safetyNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
157 Immune Checkpoint Inhibitor-Induced Ptosis in a Patient With Prostate CancerAdenocarcinoma / drug therapy; Aged; Blepharoptosis / chemically induced; Drug Therapy, Combination / adverse effects; Humans; Immune Checkpoint Inhibitors / adverse effects; Immune Checkpoint Inhibitors / therapeutic use; Ipilimumab / adverse effects; Ipilimumab / therapeutic use; Male; Nivolumab /...
158 Never Too Young or Too OldNeuromyelitis Optica Spectrum Disorder (NMOSD); Myasthenia Gravis; Optic Chiasm; Optic NeuritisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
159 Ocular Myasthenia Gravis: Toward a Risk of Generalization Score and Sample Size Calculation for a Randomized Controlled Trial of Disease ModificationBiopsy; Blepharoptosis; Diagnosis, Differential; Diplopia; Female; Humans; Magnetic Resonance Imaging; Middle Older people; Oculomotor Muscles; Ophthalmoplegia, Chronic Progressive External; SaccadesNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
160 Ocular Myasthenia Gravis Associated With Thymic AmyloidosisAmyloidosis; Autoantibodies; Blepharoptosis; Diplopia; Female; Glucocorticoids; Humans; Lymphatic Diseases; Magnetic Resonance Imaging; Middle Older people; Myasthenia Gravis; Receptors, Cholinergic; Thymectomy; Thymus GlandNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
161 A Case of Silent Sinus Syndrome Caused by a Dacryocystorhinostomy Presenting as Myasthenia GravisSilent Sinus Syndrome (SSS) is a rare entity defined as spontaneous, progressive enophthalmos and hypoglobus from maxillary sinus hypoplasia due to chronic maxillary sinus obstruction1. We present a unique case of silent sinus syndrome caused by a dacryocystorhinostomy presenting as myasthenia gravi...Silent Sinus Syndrome; Maxillary Sinus Hypoplasia; Dacryocystorhinostomy; Hypoglobus; DiplopiaNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
162 The Effects of Edrophonium on Eyelid SaccadesThe first diagnostic use of an anticholinesterase in myasthenia gravis included observations on its effect on ptosis. Subsequently, the response of myasthenic eye movements to edrophonium has been extensively studied with quantitative techniques. However, the effect of this drug on lid dynamics has ...Edrophonium; Eyelid Saccades; Myasthenia Gravis; PtosisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
163 Peripheral Inflammatory Processes Affecting Ocular Motor FunctionMyasthenia gravis is a disorder of neuromuscular transmission. Normally, acetylcholine is packaged into vesicles which are then released into the cleft at the neuromuscular junction. Receptors bind the acetylcholine to initiate depolarization of the muscle membrane.Ocular Myasthenia Gravis; Thyroid Ophthalmology; Miller-Fisher Syndrome; Neuromuscular Transmission DiseaseNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
164 Clinical and subclinical oculomotor findings in the Eaton-Lambert syndrome.Older people; Blepharoptosis; Diagnosis, Differential; Electrooculography; Eye Movements; Female; Humans; Male; Middle Older people; Muscular Diseases; Myasthenia Gravis; Saccades; Visual Acuity
165 Chest CT Thymoma (Guest Lecture)The patient is a 46 year old woman who presented in July 1977 with horizontal double vision lasting two weeks. Three weeks later the left upper eyelid started to droop and by the end of the day the eye was closed. She had no ptosis of the right eye and no generalized fatigue. She consulted an intern...Unilateral Ptosis; Unilateral Lid Retraction; Myasthenic Lid Twitch; External Ophthalmoplegia; Ocular Myasthenia Gravis; Tensilon Test; Thymolipoma; Generalized Myasthenia Gravis; Unilateral Myasthenia Gravis; Myasthenic Ptosis; Lid Retraction; Lid TwitchNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
166 Hodgkin Lymphoma Diagnosed on Work-up for Ocular MyastheniaWe present a case of inferior rectus weakness with myasthenic features which led to a diagnosis of classic Hodgkin lymphoma.Myasthenia, Ocular Motility, Tumors, Neuro-ophth & systyemic disease ( eg. MS, MG, thyroid)Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
167 Quantification of Saccadic Fatigability for a Diagnosis of Myasthenia GravisSymptoms of myasthenia gravis (MG) are characterized by fatigable and fluctuating weakness with repeated use of muscle. The diagnosis of MG was combined with clinical symptoms and ancillary tests. However, each study has reported different sensitivity and specificity of the test, so there are variou...Myasthenia; Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid)Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
168 The Study of Extraocular Muscle in Ocular Myasthenia GravisMyasthenia gravis (MG) is a neuromuscular junction disorder that frequently affects the extraocular muscles. Atrophic extraocular muscles have been reported in a few cases with ocular MG. It has been observed particularly in chronic cases with treatment difficulties. A few pathological studies demon...Myasthenia; Ocular MotilityNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
169 Differences and Similarities Between Idiopathic Intracranial Hypertension, Ocular Myasthenia Gravis, Optic Neuritis, and Horner's In Children Vs. AdultsPediatric neuro-ophthalmology is more than just neuroophthalmology of little people. Compared with neuro-ophthalmology in adults, in the pediatric subspecialty the diseases are different, with greater emphases on congenital malformations and genetic disorders and less on vascular problems.Idiopathic Intracranial Hypertension (Pseudotumor Cerebri); Pediatric Optic Neuritis; Ocular Myasthenia Gravis; Horner's SyndromeNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
170 Walsh & Hoyt: Pediatric Myasthenia GravisAutoimmune MG can occur at any age. One clinical challenge in ""juvenile-onset"" myasthenia is to distinguish antibody-mediated disease from gene mutations affecting NMJ ion channels. Juvenile-onset autoimmune MG differs little from adult-onset disease, except that it may improve with age. It respon...Ocular Motor System; Pediatric Myasthenia GravisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
171 Mitochondrial Ophthalmoplegia with Fatigable Weakness and Elevated Acetylcholine Receptor AntibodyAdult; Antibodies, blood; Biological Markers, blood; Biopsy; Diagnosis, Differential; Disease Progression; Electromyography; Electroretinography; Eye Movements, physiology; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Microscopy, Electron; Muscle Fatigue, physiology; Oculomotor Muscl...
172 The Effect of Corticosteroids on the Progression of Ocular Myasthenia to Generalized MyastheniaIn previously published reports, 49% to 69% of patients with Ocular Myasthenia (OMG) will progress to Generalized Myasthenia Gravis (GMG without any medical intervention. Of the patients with only ocular manifestations at onset who later develop symptoms of generalized myasthenia, 60% to 80% will do...Corticosteroids; Ocular Myasthenia; Myasthenia; Generalized Myasthenia GravisNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
173 Walsh & Hoyt: Eaton-Lambert Syndrome: A Paraneoplastic Disorder of the Neuromuscular JunctionA disorder resembling myasthenia gravis, occurring in patients with bronchogenic carcinoma, was first described by Anderson et al. in 1953. During the next decade, Eaton, Lambert, Rooke, and their associates at the Mayo Clinic studied the clinical and physiologic characteristics of this disorder in ...Neoplasms; Paraneoplastic Syndrome; Eaton-Lambert Syndrome; Paraneoplastic Disorder, Neuromuscular JunctionNeuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu
174 Myasthenia gravis and Charcot-Marie-Tooth disease.Adult; Older people; Charcot-Marie-Tooth Disease; Edrophonium; Eye Diseases; Humans; Male; Muscular Atrophy; Myasthenia Gravis
175 Lid Nystagmus as a Sign of Intrinsic Midbrain DiseaseAstrocytoma/diagnosis; Astrocytoma/radiotherapy; Blepharoptosis/complications; Brain Neoplasms/diagnosis; Brain Neoplasms/radiotherapy; Child; Eye Movements; Eyelid Diseases/diagnosis; Humans; Magnetic Resonance Imaging; Male; Mesencephalon/pathology; Myasthenia Gravis/diagnosis; Nystagmus, Patholog...
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