The Alfredo A. Sadun Neuro-Ophthalmology Collection: A Professor of Ophthalmology and Neurological Surgery at the USC Keck School of Medicine, Dr. Sadun with a team of researchers at the Doheny Eye Institute pioneered research in optic nerve dysfunction in patients with Alzheimer's disease. Contains his "100 best lectures." Alfredo A. Sadun, MD, PhD, Flora L. Thornton Chair, Professor Ophthalmology & Neurological Surgery, Doheny Eye Institute, Keck School of Medicine at USC.
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A Neuro-Ophthalmologist's View of RGC Apoptosis and Neuroprotection | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunodeficiency Syndrome; Glaucoma. Presen... | Text |
| 2 |
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Anatomy and Physiology of the Optic Nerve | Lecture covering the anatomy and physiology of the optic nerve. Covers the retina and anterior visual pathways. Several slides show microscopic images of optic nerve damage. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Text |
| 3 |
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Anatomy and Physiology of Vision: The Visual Pathways | Introduction to neuro-ophthalmology, covering the optic nerve, the afferent visual system (eye to brain), the pupil (Afferent-Efferent Reflex), and the efferent visual system (eye movements). Anatomy: Optic nerve; Optic disc; Retina; Retinal ganglion cells; Optic chiasm; Visual cortex. Disease/Diagn... | Text |
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Apoptosis of Retinal Ganglion Cells | Presented at a conference on neuroprotection at Sedona, Arizona, 2002; includes several microscopic images demonstrating cell death. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Cytokines. Disease/Diagnosis: Glaucoma. | Text |
| 5 |
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Beyond the Margulis Hypothesis: The Time Bomb Within Us | Presented at 36th Annual Doheny Days, 2005. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. | Text |
| 6 |
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Circadian Rhythms: How Much Retina Do We Need for a Good Night's Sleep? | Discusses importance of the health of the retinohypothalamic tract in the maintenance of circadian rhythm. Anatomy: Retina; Hypothalamus; Retinal ganglion cells; Pineal gland. Disease/Diagnosis: Retinal diseases; Sleep disorders, Circadian rhythm. | Text |
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Color Vision: Insights Into Our Origins and Some of Our Artists - From Darwin to Delacroix | Discussion of origins and physiology of color vision in different species, distinction between addition and subtraction of colors, and how painters get around the difference. Includes microscopic views of retinal cones. Anatomy: Retina; Rods (Retina); Cones (Retina). | Text |
| 8 |
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Distinguishing an Optic Neuropathy from a Maculopathy | PPT describing a case of optic neuropathy. Covers signs and symptoms, and various laboratory tests. Describes 10 signes of disc edema. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; Afferent pupillar... | Text |
| 9 |
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Distinguishing Optic Nerve vs. Retinal Lesions | PPT describing methods of distinguishing optic nerve verses retinal lesions. Describes a pateint case. Discussed signs, symtpoms and diagnostic tests. Anatomy: Optic nerve; Retina; Retinal macula. Disease/Diagnosis: Optic nerve diseases; Retinal lesion; Macular lesion; Disorder of the optic nerve; A... | Text |
| 10 |
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Engineering the Visual System | Physiological basis of vision, covering perimetry, retinal ganglion cell types, and retinal pathways. Anatomy: Optic nerve; Retina. | Text |
| 11 |
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Headache | Presenting Symptom: Ataxia; Photophobia; Scotoma; Ischemia; Aura. Anatomy: Orbit; Retina; Serotonin. Disease/Diagnosis: Migraine disorders; Migraine with aura. Treatment: Ibuprofen; Sumatriptan; Pseudoephedrine; Lidocaine; Caffeine; Calcium channel blockers; Aminosalicylic acids. | Text |
| 12 |
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Headache and Visual Loss | Presenting Symptom: Ataxia; Photophobia; Scotoma; Ischemia; Aura. Anatomy: Orbit; Retina; Serotonin. Disease/Diagnosis: Migraine disorders; Migraine with aura. Imaging: Ibuprofen; Sumatriptan; Pseudoephedrine; Lidocaine; Caffeine; Calcium channel blockers; Aminosalicylic acids. | Text |
| 13 |
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How Mitochondria Orchestrate the Death of RGCs : From Brazil to Tuebingen to Rochester 2007 | Slides showing LHON and Kjer's optic atrophy and images of optic disk with LHON. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber. Presenting Symptom: Scotoma; Telangiectasis; Apoptosis; Dyschromatopsia; Blindness. | Text |
| 14 |
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Mitochondrial Optic Neuropathy: Mitochondria as Gatekeepers for Apoptosis | Anatomy: Optic nerve; Retina; Retinal ganglion cells; Reactive oxygen species. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Toxic optic neuropathy. Presenting Symptom: Scotoma; Dyschromatopsia. | Text |
| 15 |
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Neuroprotection = Apoptosis of Retinal Ganglion Cells | Slide presentation with several microscopic images demonstrating cell death, LHON, AIDS. Presenting Symptom: Blindness; Ischemia; Retinal detachment. Anatomy: Optic nerve; Retina; Retinal ganglion cells; Phosphopyruvate Hydratase. Disease/Diagnosis: Optic Atrophy, Hereditary, Leber; Acquired Immunod... | Text |
| 16 |
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Office Techniques for Detecting Optic Nerve Disease | Demonstration of brightness sense testing and of computer-generated graphics for Amsler grid testing. Presenting Symptom: Scotoma; Metamorphopsia. Anatomy: Optic nerve; Retina; Macula lutea. Disease/Diagnosis: Glaucoma; Optic neuritis; Macular degeneration. | Text |
| 17 |
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Optic Nerve Regeneration | A slide presentation with three sets of 3 views increasing magnification. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic neuropathy, Ischemic; Retrograde degeneration; Necrosis. Treatment: Cerestat; Aptiganel; Memantine; Riluzole. | Text |
| 18 |
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Optical Coherence Tomography (OCT) Applications in the Eye | Optical Coherence Tomography is a technique for non-invasive cross-sectional imaging of ocular tissues. This PowerPoint covers an overview of the technique with excellent diagrams and images. Anatomy: Retina; Anterior eye segment; Cornea; Macula Lutea; Vitreous body; Optic nerve; Retinal ganglion ce... | Text |
| 19 |
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Testing the Functional Patient | Discusses testing to distinguish organic ailments from psychosomatic or willful simulation of symptoms. Anatomy: Optic nerve; Retina. Disease/Diagnosis: Optic nerve diseases; Retinal degeneration; Hysteria | Text |
| 20 |
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The Visual Process: Tracing Light From the Retina to the Cortex | Physiological basis of vision, including the optics of the eye and the retina and retinal pathways. Anatomy: Retina; Cortex | Text |
| 21 |
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Visual Variants in Nature | Comparison of visual systems of various species. Anatomy: Retina; Pupil; Cones (Retina); Rods (Retina); Lens, Crystalline. | Text |
| 22 |
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Why You Should Prescribe Goggles to a Box Jellyfish | A discussion of the box jellyfish eye and visual system. Anatomy: Retina; Lens, Crystalline. | Text |
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